Neuroendocrine, inflammatory, and extracellular vesicle responses during the Navy Special Warfare Screener Selection Course.
Adolescent
Adult
Biomarkers
/ metabolism
Brain-Derived Neurotrophic Factor
/ metabolism
Cytokines
/ metabolism
Extracellular Vesicles
/ metabolism
Hormones
/ metabolism
Humans
Insulin-Like Growth Factor I
/ metabolism
Interleukin-1beta
Male
Neurosecretory Systems
/ metabolism
Tumor Necrosis Factor-alpha
/ metabolism
Vesicle-Associated Membrane Protein 3
/ metabolism
Young Adult
apoptotic bodies
biomarkers
exosomes
microvesicles
stress
Journal
Physiological genomics
ISSN: 1531-2267
Titre abrégé: Physiol Genomics
Pays: United States
ID NLM: 9815683
Informations de publication
Date de publication:
01 08 2022
01 08 2022
Historique:
pubmed:
14
6
2022
medline:
20
7
2022
entrez:
13
6
2022
Statut:
ppublish
Résumé
Military operational stress is known to increase adrenal hormones and inflammatory cytokines, while decreasing hormones associated with the anabolic milieu and neuroendocrine system. Less is known about the role of extracellular vesicles (EVs), a form of cell-to-cell communication, in military operational stress and their relationship to circulating hormones. The purpose of this study was to characterize the neuroendocrine, cytokine, and EV response to an intense. 24-h selection course known as the Naval Special Warfare (NSW) Screener and identify associations between EVs and cytokines. Blood samples were collected the morning of and following the NSW Screener in 29 men (18-26 yr). Samples were analyzed for concentrations of cortisol, insulin-like growth factor I (IGF-I), neuropeptide-Y (NPY), brain-derived neurotrophic factor (BDNF), α-klotho, tumor necrosis factor-α (TNFα), and interleukins (IL) -1β, -6, and -10. EVs stained with markers associated with exosomes (CD63), microvesicles (VAMP3), and apoptotic bodies (THSD1) were characterized using imaging flow cytometry and vesicle flow cytometry. The selection event induced significant changes in circulating BDNF (-43.2%), IGF-I (-24.6%), TNFα (+17.7%), and IL-6 (+13.6%) accompanied by increases in intensities of THSD1
Identifiants
pubmed: 35695270
doi: 10.1152/physiolgenomics.00184.2021
pmc: PMC9291410
doi:
Substances chimiques
Biomarkers
0
Brain-Derived Neurotrophic Factor
0
Cytokines
0
Hormones
0
Interleukin-1beta
0
Tumor Necrosis Factor-alpha
0
Vesicle-Associated Membrane Protein 3
0
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
283-295Subventions
Organisme : NIH HHS
ID : S10 OD019942
Pays : United States
Références
J Clin Endocrinol Metab. 2014 Mar;99(3):956-64
pubmed: 24423293
Sci Rep. 2018 Nov 21;8(1):17216
pubmed: 30464183
Cold Spring Harb Perspect Med. 2018 Mar 1;8(3):
pubmed: 28490541
Psychopharmacology (Berl). 2002 Nov;164(3):250-61
pubmed: 12424548
J Neurooncol. 2013 May;113(1):1-11
pubmed: 23456661
J Immunol. 2007 Aug 1;179(3):1913-25
pubmed: 17641058
Curr Opin Clin Nutr Metab Care. 2010 Sep;13(5):541-7
pubmed: 20657280
Front Immunol. 2018 Apr 30;9:738
pubmed: 29760691
Front Physiol. 2017 Nov 02;8:882
pubmed: 29163218
Scand J Clin Lab Invest. 2016 Sep;76(5):349-60
pubmed: 27195974
Int J Biol Sci. 2018 Sep 7;14(12):1610-1620
pubmed: 30416375
J Appl Physiol (1985). 2003 Sep;95(3):1083-9
pubmed: 12909598
Nat Rev Drug Discov. 2013 May;12(5):347-57
pubmed: 23584393
Nutrients. 2014 May 12;6(5):1945-55
pubmed: 24824290
J Extracell Vesicles. 2015 Jul 02;4:28239
pubmed: 26142461
Eur J Sport Sci. 2022 Jan;22(1):72-86
pubmed: 34346851
Dev Cell. 2011 Jul 19;21(1):77-91
pubmed: 21763610
J Thromb Haemost. 2012 Mar;10(3):437-46
pubmed: 22212198
Curr Biol. 2018 Apr 23;28(8):R435-R444
pubmed: 29689228
J Immunol. 2004 Jan 15;172(2):1028-35
pubmed: 14707076
Semin Immunol. 2014 Oct;26(5):394-401
pubmed: 24405946
Clin Hemorheol Microcirc. 2011;47(1):15-25
pubmed: 21321404
J Extracell Vesicles. 2022 Jan;11(1):e12151
pubmed: 35041249
J Neuroimmune Pharmacol. 2020 Sep;15(3):443-458
pubmed: 31485884
Physiol Behav. 2016 Oct 15;165:86-97
pubmed: 27374427
Med Sci Sports Exerc. 2009 Jun;41(6):1261-70
pubmed: 19461539
Circulation. 2004 Dec 7;110(23):3599-603
pubmed: 15569844
Biol Psychiatry. 2000 May 15;47(10):891-901
pubmed: 10807962
Med Sci Sports Exerc. 2007 Aug;39(8):1380-7
pubmed: 17762372
Scand J Clin Lab Invest. 2012 Nov;72(7):547-54
pubmed: 22862430
Sci Adv. 2020 Aug 12;6(33):eaaz0748
pubmed: 32851154
Biomedicines. 2021 Jan 27;9(2):
pubmed: 33513846
J Extracell Vesicles. 2022 Feb;11(2):e12162
pubmed: 35102719
J Appl Physiol (1985). 2000 May;88(5):1820-30
pubmed: 10797147
Proc Nutr Soc. 2004 May;63(2):263-7
pubmed: 15294041
Aerosp Med Hum Perform. 2018 Feb 1;89(2):99-107
pubmed: 29463354
Sci Rep. 2018 Jun 12;8(1):8973
pubmed: 29895824
Cell Mol Life Sci. 2002 Aug;59(8):1347-57
pubmed: 12363037
Biol Psychiatry. 2009 Aug 15;66(4):334-40
pubmed: 19500775
Sci Rep. 2021 Jun 16;11(1):12615
pubmed: 34135428
Metabolism. 2011 Mar;60(3):335-50
pubmed: 20304442
Pharmacol Rev. 2012 Jul;64(3):676-705
pubmed: 22722893
J Extracell Vesicles. 2015 May 14;4:27066
pubmed: 25979354
J Extracell Vesicles. 2020 Nov;10(1):e12028
pubmed: 33613872
Front Neuroendocrinol. 2009 Jan;30(1):30-45
pubmed: 19017533
Front Immunol. 2020 Sep 30;11:1814
pubmed: 33101266
Biomedicines. 2021 Feb 25;9(3):
pubmed: 33669043
Physiol Behav. 2021 Jul 1;236:113413
pubmed: 33811909
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
J Exp Psychol Gen. 2012 Feb;141(1):2-18
pubmed: 21823805
J Immunol Methods. 2016 Nov;438:11-20
pubmed: 27568281
J Diabetes Sci Technol. 2009 Mar 01;3(2):371-6
pubmed: 20144370
PLoS One. 2016 Feb 22;11(2):e0149866
pubmed: 26901428
Front Physiol. 2021 Feb 01;11:604274
pubmed: 33597890
Am J Physiol Regul Integr Comp Physiol. 2022 Feb 1;322(2):R112-R122
pubmed: 34907783
Res Sports Med. 2010 Apr;18(2):127-39
pubmed: 20397115
Med Sci Sports Exerc. 2000 Feb;32(2):317-31
pubmed: 10694113
Behav Med. 2020 Jul-Sep;46(3-4):290-301
pubmed: 32787719
BMJ Open Sport Exerc Med. 2017 Sep 17;3(1):e000261
pubmed: 29177073
Immunity. 2001 Nov;15(5):825-35
pubmed: 11728343
PLoS One. 2014 Feb 24;9(2):e89455
pubmed: 24586790
Exp Physiol. 2009 Dec;94(12):1153-60
pubmed: 19748969
Cells. 2021 Feb 24;10(3):
pubmed: 33668220
J Cell Physiol. 2021 May;236(5):3336-3353
pubmed: 33037627
Physiol Rep. 2018 Sep;6(17):e13850
pubmed: 30187684
Diabetologia. 2009 Jul;52(7):1409-18
pubmed: 19387610
Int J Mol Sci. 2020 Sep 26;21(19):
pubmed: 32993051