Biomolecular condensates in epithelial junctions.

Biomolecular Condensates Cell Membrane Cell Polarity / physiology Epithelial Cells Proteins / metabolism Tight Junctions / metabolism

Journal

Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428

Informations de publication

Date de publication:
08 2022
Historique:
received: 03 01 2022
revised: 05 04 2022
accepted: 15 04 2022
pubmed: 14 6 2022
medline: 11 8 2022
entrez: 13 6 2022
Statut: ppublish

Résumé

Epithelial junctions are transmembrane protein complexes that regulate cell adhesion, cell polarity, tissue permeability, and tissue mechanics. Most junctional complexes contain membrane attached cytoplasmic plaques that regulate junction assembly and are composed of multivalent scaffold proteins. In this review, we discuss phase separation of multivalent proteins as a general process that drives assembly of many membrane-less cellular compartments. And we summarise recent evidence that phase separation of junctional scaffold proteins is involved in the assembly of tight junctions and focal adhesions.

Identifiants

DOI: 10.1016/j.ceb.2022.102089 PMID: 35696872
pubmed: 35696872
pii: S0955-0674(22)00042-4
doi: 10.1016/j.ceb.2022.102089
pii:
doi:

Substances chimiques

Proteins 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102089

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest statement Nothing declared.

Auteurs

Daxiao Sun (D)

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Isabel LuValle-Burke (I)

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Karina Pombo-García (K)

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Alf Honigmann (A)

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany; Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität, Dresden, Germany. Electronic address: honigmann@mpi-cbg.de.

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Condensats biomoléculaires › Biomolecular condensates in epithelial junctions.
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Biomolecular condensates in epithelial junctions.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Polarité de la cellule › Biomolecular condensates in epithelial junctions.
questionsmedicales.fr › Cellules › Cellules épithéliales › Biomolecular condensates in epithelial junctions.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Biomolecular condensates in epithelial junctions.
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Jonctions serrées › Biomolecular condensates in epithelial junctions.