Brain lesions disrupting addiction map to a common human brain circuit.

Alcoholism / pathology Brain / diagnostic imaging Brain Injuries / pathology Brain Mapping Cohort Studies Connectome Humans Magnetic Resonance Imaging

Journal

Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015

Informations de publication

Date de publication:
06 2022
Historique:
received: 24 03 2021
accepted: 21 04 2022
pubmed: 14 6 2022
medline: 22 6 2022
entrez: 13 6 2022
Statut: ppublish

Résumé

Drug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to addiction remission. These cases may be used to identify therapeutic targets for neuromodulation. We analyzed two cohorts of patients addicted to smoking at the time of focal brain damage (cohort 1 n = 67; cohort 2 n = 62). Lesion locations were mapped to a brain atlas and the brain network functionally connected to each lesion location was computed using human connectome data (n = 1,000). Associations with addiction remission were identified. Generalizability was assessed using an independent cohort of patients with focal brain damage and alcohol addiction risk scores (n = 186). Specificity was assessed through comparison to 37 other neuropsychological variables. Lesions disrupting smoking addiction occurred in many different brain locations but were characterized by a specific pattern of brain connectivity. This pattern involved positive connectivity to the dorsal cingulate, lateral prefrontal cortex, and insula and negative connectivity to the medial prefrontal and temporal cortex. This circuit was reproducible across independent lesion cohorts, associated with reduced alcohol addiction risk, and specific to addiction metrics. Hubs that best matched the connectivity profile for addiction remission were the paracingulate gyrus, left frontal operculum, and medial fronto-polar cortex. We conclude that brain lesions disrupting addiction map to a specific human brain circuit and that hubs in this circuit provide testable targets for therapeutic neuromodulation.

Identifiants

DOI: 10.1038/s41591-022-01834-y PMID: 35697842 PMC: PMC9205767
pubmed: 35697842
doi: 10.1038/s41591-022-01834-y
pii: 10.1038/s41591-022-01834-y
pmc: PMC9205767
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1249-1255

Subventions

Organisme : NIMH NIH HHS
ID : K23 MH120510
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054328
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD105351
Pays : United States
Organisme : NIDA NIH HHS
ID : K99 DA048085
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113929
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS123813
Pays : United States
Organisme : NIMH NIH HHS
ID : L30 MH127717
Pays : United States
Organisme : NIDA NIH HHS
ID : R00 DA048085
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH126271
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH121657
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG069086
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114405
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103556
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Juho Joutsa (J)

Turku Brain and Mind Center, Clinical Neurosciences, University of Turku, Turku, Finland. jtjout@utu.fi.
Neurocenter and Turku PET Center, Turku University Hospital, Turku, Finland. jtjout@utu.fi.
Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Boston, MA, USA. jtjout@utu.fi.
ORCID: 0000-0002-3457-9415

Khaled Moussawi (K)

National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD, USA.
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0001-6378-0428

Shan H Siddiqi (SH)

Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Center for Brain Circuit Therapeutics, Departments of Neurology Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Amir Abdolahi (A)

Clinical Affairs, Philips Healthcare, Cambridge, MA, USA.

William Drew (W)

Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Center for Brain Circuit Therapeutics, Departments of Neurology Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-9178-8731

Alexander L Cohen (AL)

Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Center for Brain Circuit Therapeutics, Departments of Neurology Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Neurology, Boston Children's Hospital, Boston, MA, USA.
Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-6557-5866

Thomas J Ross (TJ)

National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD, USA.
ORCID: 0000-0002-7745-3572

Harshawardhan U Deshpande (HU)

National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD, USA.
ORCID: 0000-0001-8620-8280

Henry Z Wang (HZ)

Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, USA.

Joel Bruss (J)

Departments of Pediatrics, Neurology & Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Elliot A Stein (EA)

National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD, USA.
ORCID: 0000-0003-0593-0269

Nora D Volkow (ND)

Intramural Research Program, National Institute of Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
ORCID: 0000-0001-6668-0908

Jordan H Grafman (JH)

Shirley Ryan AbilityLab, Chicago, IL, USA.
Department of Physical Medicine and Rehabilitation, Neurology, Cognitive Neurology and Alzheimer's Center, Northwestern University, Chicago, IL, USA.
Department of Psychiatry, Feinberg School of Medicine and Department of Psychology, Weinberg College of Arts and Sciences, Northwestern University, Chicago, IL, USA.

Edwin van Wijngaarden (E)

Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA.

Aaron D Boes (AD)

Departments of Pediatrics, Neurology & Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
ORCID: 0000-0002-7865-9257

Michael D Fox (MD)

Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Boston, MA, USA. foxmdphd@gmail.com.
Center for Brain Circuit Therapeutics, Departments of Neurology Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. foxmdphd@gmail.com.
ORCID: 0000-0001-8848-6399

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Troubles liés à l'alcool › Alcoolisme › Brain lesions disrupting addiction map to a...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Brain lesions disrupting addiction map to a...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Brain lesions disrupting addiction map to a...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Brain lesions disrupting addiction map to a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Brain lesions disrupting addiction map to a...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Connectome › Brain lesions disrupting addiction map to a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Brain lesions disrupting addiction map to a...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Brain lesions disrupting addiction map to a...