Discordance between HIV-1 Population in Plasma at Rebound after Structured Treatment Interruption and Archived Provirus Population in Peripheral Blood Mononuclear Cells.

Anti-Retroviral Agents / therapeutic use CD4-Positive T-Lymphocytes HIV Infections / drug therapy HIV-1 / genetics Humans Leukocytes, Mononuclear Proviruses / genetics Viral Load Viremia / drug therapy
HIV-1 PBMCs persistence plasma rebound reservoir reservoirs therapy interruption

Journal

Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614

Informations de publication

Date de publication:
31 08 2022
Historique:
pubmed: 15 6 2022
medline: 9 9 2022
entrez: 14 6 2022
Statut: ppublish

Résumé

Antiretroviral therapy (ART) can sustain the suppression of plasma viremia to below detection levels. Infected individuals undergoing a treatment interruption exhibit rapid viral rebound in plasma viremia which is fueled by cellular reservoirs such as CD4

Identifiants

DOI: 10.1128/spectrum.01353-22 PMID: 35699458 PMC: PMC9431602
pubmed: 35699458
doi: 10.1128/spectrum.01353-22
pmc: PMC9431602
doi:

Substances chimiques

Anti-Retroviral Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0135322

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Auteurs

Chynna M Hendricks (CM)

Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, Florida, USA.

Melanie N Cash (MN)

Emerging Pathogens Institute, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Department of Pathology, Immunology and Laboratory Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.

Massimiliano S Tagliamonte (MS)

Emerging Pathogens Institute, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Department of Pathology, Immunology and Laboratory Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.
ORCID: 0000-0003-2699-7331

Alberto Riva (A)

Interdisciplinary Center for Biotechnology Research, University of Floridagrid.15276.37, Gainesville, Florida, USA.

Christian Brander (C)

Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

Anuska Llano (A)

Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

Marco Salemi (M)

Emerging Pathogens Institute, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Department of Pathology, Immunology and Laboratory Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.
ORCID: 0000-0003-0136-2102

Mario Stevenson (M)

Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida, USA.
Division of Infectious Diseases, University of Miami, Miller School of Medicine, Miami, Florida, USA.

Carla Mavian (C)

Emerging Pathogens Institute, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Department of Pathology, Immunology and Laboratory Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antirétroviraux › Discordance between HIV-1 Population in Plasma...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Discordance between HIV-1 Population in Plasma...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Discordance between HIV-1 Population in Plasma...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Discordance between HIV-1 Population in Plasma...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discordance between HIV-1 Population in Plasma...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Discordance between HIV-1 Population in Plasma...
questionsmedicales.fr › Virus › Provirus › Discordance between HIV-1 Population in Plasma...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › Discordance between HIV-1 Population in Plasma...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Virémie › Discordance between HIV-1 Population in Plasma...