Androglobin, a chimeric mammalian globin, is required for male fertility.
calmodulin
cell biology
developmental biology
globin
heme
infertility
mouse
oxygen
spermatogenesis
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
14 06 2022
14 06 2022
Historique:
received:
21
07
2021
accepted:
13
06
2022
pubmed:
15
6
2022
medline:
6
7
2022
entrez:
14
6
2022
Statut:
epublish
Résumé
Spermatogenesis is a highly specialized differentiation process driven by a dynamic gene expression program and ending with the production of mature spermatozoa. Whereas hundreds of genes are known to be essential for male germline proliferation and differentiation, the contribution of several genes remains uncharacterized. The predominant expression of the latest globin family member, androglobin (Adgb), in mammalian testis tissue prompted us to assess its physiological function in spermatogenesis. Adgb knockout mice display male infertility, reduced testis weight, impaired maturation of elongating spermatids, abnormal sperm shape, and ultrastructural defects in microtubule and mitochondrial organization. Epididymal sperm from Adgb knockout animals display multiple flagellar malformations including coiled, bifid or shortened flagella, and erratic acrosomal development. Following immunoprecipitation and mass spectrometry, we could identify septin 10 (Sept10) as interactor of Adgb. The Sept10-Adgb interaction was confirmed both
Identifiants
pubmed: 35700329
doi: 10.7554/eLife.72374
pii: 72374
pmc: PMC9249397
doi:
pii:
Substances chimiques
Globins
9004-22-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022, Keppner et al.
Déclaration de conflit d'intérêts
AK, MC, SS, TK, DM, CO, DW, AC, MS, FC, SD, AO, DK, TH, RW, DH No competing interests declared
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