Cytochrome

Animals Astemizole Butyrophenones Cats / genetics Cytochrome P-450 CYP2J2 Cytochrome P-450 Enzyme System / genetics Dogs / genetics Humans Phylogeny Piperidines Swine / genetics Terfenadine

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
11 2022
Historique:
received: 22 04 2022
accepted: 18 05 2022
pubmed: 15 6 2022
medline: 12 10 2022
entrez: 14 6 2022
Statut: ppublish

Résumé

Cytochrome P450s (P450s) have been identified and analyzed in dogs and pigs, species that are often used in preclinical drug studies. Moreover, P450s are clinically important for drug therapy not only in humans, but also in species under veterinary care, including dogs and cats. In the present study, seven P450s homologous to human CYP2J2, namely, dog CYP2J2; cat CYP2J2; and pig CYP2J33, CYP2J35, CYP2J91, and CYP2J93, were newly identified and characterized, along with pig CYP2J34 previously identified. The cDNAs of these CYP2Js contain open reading frames of 502 amino acids, except for CYP2J35 (498 amino acids), and share high sequence identity (77%-80%) with human CYP2J2. Phylogenetic analysis revealed that dog and cat CYP2J2 were closely related, whereas pig CYP2Js formed a cluster. All seven

Identifiants

DOI: 10.1124/dmd.122.000930 PMID: 35701183
pubmed: 35701183
pii: dmd.122.000930
doi: 10.1124/dmd.122.000930
doi:

Substances chimiques

Butyrophenones 0
Piperidines 0
Terfenadine 7BA5G9Y06Q
Astemizole 7HU6337315
Cytochrome P-450 Enzyme System 9035-51-2
Cytochrome P-450 CYP2J2 EC 1.14.14.1
ebastine TQD7Q784P1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1434-1441

Informations de copyright

Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

Yasuhiro Uno (Y)

Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan (Y.U., M.Ij., O.Y., M.S., A.A.); Showa Pharmaceutical University, Machida, Japan (N.M., H.Y.); School of Veterinary Medicine, Kitasato University, Towadashi, Japan (H.K.); School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan (H.T.); Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (H.M., S.M.M.N., Y.I., M.Is.); and Graduate School of Agriculture, Ehime University, Matsuyama, Japan (H.M.) unoxx001@vet.kagoshima-u.ac.jp hyamazak@ac.shoyaku.ac.jp.

Norie Murayama (N)

Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan (Y.U., M.Ij., O.Y., M.S., A.A.); Showa Pharmaceutical University, Machida, Japan (N.M., H.Y.); School of Veterinary Medicine, Kitasato University, Towadashi, Japan (H.K.); School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan (H.T.); Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (H.M., S.M.M.N., Y.I., M.Is.); and Graduate School of Agriculture, Ehime University, Matsuyama, Japan (H.M.).

Moe Ijiri (M)

Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan (Y.U., M.Ij., O.Y., M.S., A.A.); Showa Pharmaceutical University, Machida, Japan (N.M., H.Y.); School of Veterinary Medicine, Kitasato University, Towadashi, Japan (H.K.); School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan (H.T.); Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (H.M., S.M.M.N., Y.I., M.Is.); and Graduate School of Agriculture, Ehime University, Matsuyama, Japan (H.M.).

Hiroaki Kawaguchi (H)

Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan (Y.U., M.Ij., O.Y., M.S., A.A.); Showa Pharmaceutical University, Machida, Japan (N.M., H.Y.); School of Veterinary Medicine, Kitasato University, Towadashi, Japan (H.K.); School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan (H.T.); Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (H.M., S.M.M.N., Y.I., M.Is.); and Graduate School of Agriculture, Ehime University, Matsuyama, Japan (H.M.).

Osamu Yamato (O)

Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan (Y.U., M.Ij., O.Y., M.S., A.A.); Showa Pharmaceutical University, Machida, Japan (N.M., H.Y.); School of Veterinary Medicine, Kitasato University, Towadashi, Japan (H.K.); School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan (H.T.); Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (H.M., S.M.M.N., Y.I., M.Is.); and Graduate School of Agriculture, Ehime University, Matsuyama, Japan (H.M.).

Mitsuya Shiraishi (M)

Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan (Y.U., M.Ij., O.Y., M.S., A.A.); Showa Pharmaceutical University, Machida, Japan (N.M., H.Y.); School of Veterinary Medicine, Kitasato University, Towadashi, Japan (H.K.); School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan (H.T.); Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (H.M., S.M.M.N., Y.I., M.Is.); and Graduate School of Agriculture, Ehime University, Matsuyama, Japan (H.M.).

Atsushi Asano (A)

Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan (Y.U., M.Ij., O.Y., M.S., A.A.); Showa Pharmaceutical University, Machida, Japan (N.M., H.Y.); School of Veterinary Medicine, Kitasato University, Towadashi, Japan (H.K.); School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan (H.T.); Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (H.M., S.M.M.N., Y.I., M.Is.); and Graduate School of Agriculture, Ehime University, Matsuyama, Japan (H.M.).

Hiroki Teraoka (H)

Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan (Y.U., M.Ij., O.Y., M.S., A.A.); Showa Pharmaceutical University, Machida, Japan (N.M., H.Y.); School of Veterinary Medicine, Kitasato University, Towadashi, Japan (H.K.); School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan (H.T.); Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (H.M., S.M.M.N., Y.I., M.Is.); and Graduate School of Agriculture, Ehime University, Matsuyama, Japan (H.M.).

Hazuki Mizukawa (H)

Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan (Y.U., M.Ij., O.Y., M.S., A.A.); Showa Pharmaceutical University, Machida, Japan (N.M., H.Y.); School of Veterinary Medicine, Kitasato University, Towadashi, Japan (H.K.); School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan (H.T.); Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (H.M., S.M.M.N., Y.I., M.Is.); and Graduate School of Agriculture, Ehime University, Matsuyama, Japan (H.M.).

Shouta M M Nakayama (SMM)

Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan (Y.U., M.Ij., O.Y., M.S., A.A.); Showa Pharmaceutical University, Machida, Japan (N.M., H.Y.); School of Veterinary Medicine, Kitasato University, Towadashi, Japan (H.K.); School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan (H.T.); Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (H.M., S.M.M.N., Y.I., M.Is.); and Graduate School of Agriculture, Ehime University, Matsuyama, Japan (H.M.).

Yoshinori Ikenaka (Y)

Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan (Y.U., M.Ij., O.Y., M.S., A.A.); Showa Pharmaceutical University, Machida, Japan (N.M., H.Y.); School of Veterinary Medicine, Kitasato University, Towadashi, Japan (H.K.); School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan (H.T.); Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (H.M., S.M.M.N., Y.I., M.Is.); and Graduate School of Agriculture, Ehime University, Matsuyama, Japan (H.M.).

Mayumi Ishizuka (M)

Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan (Y.U., M.Ij., O.Y., M.S., A.A.); Showa Pharmaceutical University, Machida, Japan (N.M., H.Y.); School of Veterinary Medicine, Kitasato University, Towadashi, Japan (H.K.); School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan (H.T.); Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (H.M., S.M.M.N., Y.I., M.Is.); and Graduate School of Agriculture, Ehime University, Matsuyama, Japan (H.M.).

Hiroshi Yamazaki (H)

Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan (Y.U., M.Ij., O.Y., M.S., A.A.); Showa Pharmaceutical University, Machida, Japan (N.M., H.Y.); School of Veterinary Medicine, Kitasato University, Towadashi, Japan (H.K.); School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan (H.T.); Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (H.M., S.M.M.N., Y.I., M.Is.); and Graduate School of Agriculture, Ehime University, Matsuyama, Japan (H.M.) unoxx001@vet.kagoshima-u.ac.jp hyamazak@ac.shoyaku.ac.jp.
ORCID: 0000-0002-1068-4261

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cytochrome
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzimidazoles › Astémizole › Cytochrome
questionsmedicales.fr › Composés chimiques organiques › Cétones › Butyrophénones › Cytochrome
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Feliformia › Felidae › Felis › Chats › Cytochrome
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › CYP2J2 du cytochrome P450 › Cytochrome
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Cytochrome
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Cytochrome
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cytochrome
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Cytochrome
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Cytochrome
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Cytochrome
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Terfénadine › Cytochrome