Pediatric Celiac Disease and Selective IgA Deficiency: Unexpected Sequence of Events.
Celiac disease
Children
IgA deficiency
Journal
Journal of clinical immunology
ISSN: 1573-2592
Titre abrégé: J Clin Immunol
Pays: Netherlands
ID NLM: 8102137
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
25
03
2022
accepted:
25
05
2022
pubmed:
15
6
2022
medline:
12
10
2022
entrez:
14
6
2022
Statut:
ppublish
Résumé
Selective IgA deficiency (IgAD) is the most common primary immunodeficiency, frequently leading to only minor clinical complaints. IgAD may be associated with autoimmune diseases such as celiac disease (CeD). Although IgAD is thought to precede CeD and autoimmunity, the association between the two conditions has not been clarified. Routine techniques were used to measure serum IgA and celiac diagnostic markers as transglutaminase 2 IgA (TG2-IgA) and deamidated gliadin IgG and for immunohistochemistry for IgG, IgM, and IgA. We report two childhood cases of complete IgA deficiency that evolved after the diagnosis of CeD and the start of a gluten-free diet. Histology showed persistence of IgA in the intestinal mucosa. Both children with CeD showed IgA deficiency that unexpectedly developed after the initiation of a gluten-free diet. This supports IgA deficiency as a process that develops gradually and occurs due to specific defects in immunoregulation.
Identifiants
pubmed: 35701710
doi: 10.1007/s10875-022-01297-3
pii: 10.1007/s10875-022-01297-3
doi:
Substances chimiques
Autoantibodies
0
Immunoglobulin A
0
Immunoglobulin G
0
Immunoglobulin M
0
Gliadin
9007-90-3
Transglutaminases
EC 2.3.2.13
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1342-1346Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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pubmed: 6984709