Penicillin plus Ceftriaxone versus Ampicillin plus Ceftriaxone Synergistic Potential against Clinical Enterococcus faecalis Blood Isolates.

Ampicillin / pharmacology Anti-Bacterial Agents / therapeutic use Ceftriaxone / pharmacology Drug Synergism Drug Therapy, Combination Enterococcus faecalis Microbial Sensitivity Tests Penicillins / pharmacology
Enterococcus faecalis ampicillin ceftriaxone penicillin synergy

Journal

Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614

Informations de publication

Date de publication:
31 08 2022
Historique:
pubmed: 16 6 2022
medline: 9 9 2022
entrez: 15 6 2022
Statut: ppublish

Résumé

Penicillin plus ceftriaxone is a promising alternative to ampicillin plus ceftriaxone for the treatment of Enterococcus faecalis infective endocarditis. Limited data is available supporting the utilization of penicillin plus ceftriaxone. A total of 20 E. faecalis isolates; one wild-type strain (JH2-2) and 19 clinical blood strains were assessed for penicillin plus ceftriaxone and ampicillin plus ceftriaxone synergy using a 24-h time-kill experiment. Susceptibility was determined by broth microdilution. Differences in bactericidal, bacteriostatic, or inactivity, as well as synergy between treatments were assessed by chi-square or Fisher exact test. All E. faecalis isolates were considered susceptible to ampicillin and penicillin. Ampicillin plus ceftriaxone versus penicillin plus ceftriaxone similarly demonstrated synergy. Bactericidal activity was more commonly observed for ampicillin plus ceftriaxone versus penicillin plus ceftriaxone. Among isolates with a penicillin MIC of 4 μg/mL (

Identifiants

DOI: 10.1128/spectrum.00621-22 PMID: 35703558 PMC: PMC9430804
pubmed: 35703558
doi: 10.1128/spectrum.00621-22
pmc: PMC9430804
doi:

Substances chimiques

Anti-Bacterial Agents 0
Penicillins 0
Ceftriaxone 75J73V1629
Ampicillin 7C782967RD

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0062122

Références

Clin Infect Dis. 2018 Jul 2;67(2):303-309
pubmed: 29390132
Antimicrob Agents Chemother. 2019 Jun 24;63(7):
pubmed: 31010856
Virulence. 2012 Aug 15;3(5):421-33
pubmed: 23076243
Antimicrob Agents Chemother. 2004 Oct;48(10):3765-72
pubmed: 15388432
J Antimicrob Chemother. 2021 Jul 15;76(8):2168-2171
pubmed: 33975351
mBio. 2018 Apr 3;9(2):
pubmed: 29615500
J Bacteriol. 2004 Mar;186(5):1221-8
pubmed: 14973044
J Am Coll Cardiol. 2020 Feb 11;75(5):482-494
pubmed: 32029130
Antimicrob Agents Chemother. 1981 Nov;20(5):634-41
pubmed: 6275779
J Infect Chemother. 2018 Oct;24(10):856-859
pubmed: 29705391
Antimicrob Agents Chemother. 2020 Dec 16;65(1):
pubmed: 33046488
Antimicrob Agents Chemother. 2020 Jun 23;64(7):
pubmed: 32393486
Antimicrob Agents Chemother. 2019 Aug 23;63(9):
pubmed: 31262769
Antimicrob Agents Chemother. 1995 Sep;39(9):1984-7
pubmed: 8540703
Circulation. 2015 Oct 13;132(15):1435-86
pubmed: 26373316
Clin Infect Dis. 2020 Mar 3;70(6):1263-1264
pubmed: 31260045
Open Forum Infect Dis. 2021 Dec 23;9(3):ofab616
pubmed: 35155713
Infect Dis (Lond). 2020 Feb;52(2):135-138
pubmed: 31566044
Antimicrob Agents Chemother. 1982 Nov;22(5):816-23
pubmed: 6295268
Microorganisms. 2021 Oct 14;9(10):
pubmed: 34683470
Antimicrob Agents Chemother. 2012 Aug;56(8):4354-9
pubmed: 22664970
Int J Pharm Compd. 2016 Jul-Aug;20(4):338-342
pubmed: 28333679
JAC Antimicrob Resist. 2021 Aug 07;3(3):dlab128
pubmed: 34377984
Pathology. 2014 Oct;46(6):544-50
pubmed: 25158809
Am J Hosp Pharm. 1982 Jan;39(1):104-8
pubmed: 6798865
Clin Infect Dis. 2013 May;56(9):1261-8
pubmed: 23392394
Diagn Microbiol Infect Dis. 2002 Dec;44(4):363-6
pubmed: 12543542
J Antimicrob Chemother. 2006 Jan;57(1):158-60
pubmed: 16308417

Auteurs

Jaclyn A Cusumano (JA)

Department of Pharmacy Practice, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Brooklyn, New York, USA.
ORCID: 0000-0003-3207-7320

Ruhma Khan (R)

Department of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Brooklyn, New York, USA.

Zeel Shah (Z)

Department of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Brooklyn, New York, USA.

Cassie Philogene (C)

Department of Pharmacy Practice, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Brooklyn, New York, USA.

Amrita Harrichand (A)

Department of Pharmacy Practice, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Brooklyn, New York, USA.

Vanthida Huang (V)

Department of Pharmacy Practice, Midwestern University College of Pharmacy-Glendale Campus, Glendale, Arizona, USA.
ORCID: 0000-0001-8028-3554

Articles similaires

Vancomycin-associated DRESS demonstrates delay in AST abnormalities.

Ahmed Hussein, Kateri L Schoettinger, Jourdan Hydol-Smith et al.
1.00
Humans Drug Hypersensitivity Syndrome Vancomycin Female Male

Management of the infected total elbow arthroplasty.

Joaquin Sanchez-Sotelo
1.00
Humans Arthroplasty, Replacement, Elbow Prosthesis-Related Infections Debridement Anti-Bacterial Agents

Mathematical modeling of vancomycin release from Poly-L-Lactic Acid-Coated implants.

Papon Thamvasupong, Kwanchanok Viravaidya-Pasuwat
1.00
Vancomycin Polyesters Anti-Bacterial Agents Models, Theoretical Drug Liberation

A retrospective analysis on optimal medical therapy for patients with symptomatic lower extremity peripheral artery disease: a French observational study.

Camille de Kermenguy, Anne Durand, Quentin Tollenaere et al.
1.00
Humans Peripheral Arterial Disease Retrospective Studies Male Female

Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Pénicillines › Benzylpénicilline › Ampicilline › Penicillin plus Ceftriaxone versus Ampicillin...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Penicillin plus Ceftriaxone versus Ampicillin...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Céfacétrile › Céfotaxime › Ceftriaxone › Penicillin plus Ceftriaxone versus Ampicillin...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Synergie des médicaments › Penicillin plus Ceftriaxone versus Ampicillin...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Penicillin plus Ceftriaxone versus Ampicillin...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Lactobacillales › Enterococcaceae › Enterococcus › Enterococcus faecalis › Penicillin plus Ceftriaxone versus Ampicillin...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Penicillin plus Ceftriaxone versus Ampicillin...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Pénicillines › Penicillin plus Ceftriaxone versus Ampicillin...