Unravelling the sex-specific diversity and functions of adrenal gland macrophages.
CP: Immunology
adrenal gland
macrophage
monocyte
sex dimorphism
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
14 06 2022
14 06 2022
Historique:
received:
09
11
2021
revised:
10
03
2022
accepted:
23
05
2022
entrez:
15
6
2022
pubmed:
16
6
2022
medline:
18
6
2022
Statut:
ppublish
Résumé
Despite the ubiquitous function of macrophages across the body, the diversity, origin, and function of adrenal gland macrophages remain largely unknown. We define the heterogeneity of adrenal gland immune cells using single-cell RNA sequencing and use genetic models to explore the developmental mechanisms yielding macrophage diversity. We define populations of monocyte-derived and embryonically seeded adrenal gland macrophages and identify a female-specific subset with low major histocompatibility complex (MHC) class II expression. In adulthood, monocyte recruitment dominates adrenal gland macrophage maintenance in female mice. Adrenal gland macrophage sub-tissular distribution follows a sex-dimorphic pattern, with MHC class II
Identifiants
pubmed: 35705045
pii: S2211-1247(22)00731-8
doi: 10.1016/j.celrep.2022.110949
pmc: PMC9210345
pii:
doi:
Substances chimiques
Histocompatibility Antigens Class II
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
110949Subventions
Organisme : NHLBI NIH HHS
ID : K99 HL138163
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL138163
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI165553
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK126753
Pays : United States
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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