Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
01 01 2023
01 01 2023
Historique:
received:
03
01
2022
accepted:
06
06
2022
pmc-release:
01
01
2024
pubmed:
17
6
2022
medline:
23
12
2022
entrez:
16
6
2022
Statut:
ppublish
Résumé
Acquired lipodystrophy is often characterized as an idiopathic subtype of lipodystrophy. Despite suspicion of an immune-mediated pathology, biomarkers such as autoantibodies are generally lacking. Here, we used an unbiased proteome-wide screening approach to identify autoantibodies to the adipocyte-specific lipid droplet protein perilipin 1 (PLIN1) in a murine model of autoimmune polyendocrine syndrome type 1 (APS1). We then tested for PLIN1 autoantibodies in human subjects with acquired lipodystrophy with two independent severe breaks in immune tolerance (including APS1) along with control subjects using a specific radioligand binding assay and indirect immunofluorescence on fat tissue. We identified autoantibodies to PLIN1 in these two cases, including the first reported case of APS1 with acquired lipodystrophy and a second patient who acquired lipodystrophy as an immune-related adverse event following cancer immunotherapy. Lastly, we also found PLIN1 autoantibodies to be specifically enriched in a subset of patients with acquired generalized lipodystrophy (17 of 46 [37%]), particularly those with panniculitis and other features of autoimmunity. These data lend additional support to new literature that suggests that PLIN1 autoantibodies represent a marker of acquired autoimmune lipodystrophies and further link them to a break in immune tolerance.
Identifiants
pubmed: 35709010
pii: 147096
doi: 10.2337/db21-1172
pmc: PMC9797316
doi:
Substances chimiques
Perilipin-1
0
Autoantibodies
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
59-70Subventions
Organisme : NIAID NIH HHS
ID : P01 AI118688
Pays : United States
Organisme : NIDDK NIH HHS
ID : F30 DK123915
Pays : United States
Organisme : NINDS NIH HHS
ID : K99 NS117800
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH122471
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK123559
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AI001175
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI097457
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK105448
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 by the American Diabetes Association.
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