Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the

Animals Chromatin Enhancer Elements, Genetic Gene Expression Regulation, Developmental Mice Promoter Regions, Genetic SOXB1 Transcription Factors / genetics Transcription Factors / metabolism
CTCF TAD allele-specific chromatin loop enhancer genome engineering transcription

Journal

Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660

Informations de publication

Date de publication:
01 06 2022
Historique:
received: 15 02 2022
accepted: 03 06 2022
pubmed: 17 6 2022
medline: 19 7 2022
entrez: 16 6 2022
Statut: ppublish

Résumé

How distal regulatory elements control gene transcription and chromatin topology is not clearly defined, yet these processes are closely linked in lineage specification during development. Through allele-specific genome editing and chromatin interaction analyses of the

Identifiants

DOI: 10.1101/gad.349489.122 PMID: 35710138 PMC: PMC9296009
pubmed: 35710138
pii: gad.349489.122
doi: 10.1101/gad.349489.122
pmc: PMC9296009
doi:

Substances chimiques

Chromatin 0
SOXB1 Transcription Factors 0
Sox2 protein, mouse 0
Transcription Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

699-717

Subventions

Organisme : NHGRI NIH HHS
ID : R01 HG010045
Pays : United States
Organisme : CIHR
ID : FRN 153186
Pays : Canada

Informations de copyright

© 2022 Taylor et al.; Published by Cold Spring Harbor Laboratory Press.

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Auteurs

Tiegh Taylor (T)

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.

Natalia Sikorska (N)

Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR7104, Centre National de la Recherche Scientifique, U1258, Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 6704 Illkirch, France.

Virlana M Shchuka (VM)

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.

Sanjay Chahar (S)

Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR7104, Centre National de la Recherche Scientifique, U1258, Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 6704 Illkirch, France.

Chenfan Ji (C)

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.

Neil N Macpherson (NN)

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.

Sakthi D Moorthy (SD)

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.

Marit A C de Kort (MAC)

Division of Gene Regulation, the Netherlands Cancer Institute, Oncode Institute, 1066CX Amsterdam, the Netherlands.

Shanelle Mullany (S)

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.

Nawrah Khader (N)

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.

Zoe E Gillespie (ZE)

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.

Lida Langroudi (L)

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.

Ian C Tobias (IC)

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.

Tineke L Lenstra (TL)

Division of Gene Regulation, the Netherlands Cancer Institute, Oncode Institute, 1066CX Amsterdam, the Netherlands.

Jennifer A Mitchell (JA)

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M55 3G5, Canada.
ORCID: 0000-0002-7147-4604

Tom Sexton (T)

Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR7104, Centre National de la Recherche Scientifique, U1258, Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 6704 Illkirch, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Transcriptional regulation and chromatin...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Transcriptional regulation and chromatin...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Éléments activateurs (génétique) › Transcriptional regulation and chromatin...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › Transcriptional regulation and chromatin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Transcriptional regulation and chromatin...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Transcriptional regulation and chromatin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription SOX › Facteurs de transcription SOX-B1 › Transcriptional regulation and chromatin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Transcriptional regulation and chromatin...