Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci.
EPC1
H3K27 methylation
H4 acetylation
HOXD
JAZF1
NuA4
PHF1
PRC2
SUZ12
TIP60
Journal
Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660
Informations de publication
Date de publication:
01 06 2022
01 06 2022
Historique:
received:
31
08
2021
accepted:
31
05
2022
pubmed:
17
6
2022
medline:
19
7
2022
entrez:
16
6
2022
Statut:
ppublish
Résumé
Chromosomal translocations frequently promote carcinogenesis by producing gain-of-function fusion proteins. Recent studies have identified highly recurrent chromosomal translocations in patients with endometrial stromal sarcomas (ESSs) and ossifying fibromyxoid tumors (OFMTs), leading to an in-frame fusion of PHF1 (PCL1) to six different subunits of the NuA4/TIP60 complex. While NuA4/TIP60 is a coactivator that acetylates chromatin and loads the H2A.Z histone variant, PHF1 is part of the Polycomb repressive complex 2 (PRC2) linked to transcriptional repression of key developmental genes through methylation of histone H3 on lysine 27. In this study, we characterize the fusion protein produced by the
Identifiants
pubmed: 35710139
pii: gad.348982.121
doi: 10.1101/gad.348982.121
pmc: PMC9296003
doi:
Substances chimiques
Chromatin
0
DNA-Binding Proteins
0
Histones
0
Polycomb-Group Proteins
0
Polycomb Repressive Complex 2
EC 2.1.1.43
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
664-683Subventions
Organisme : CIHR
ID : FDN-143314
Pays : Canada
Informations de copyright
© 2022 Sudarshan et al.; Published by Cold Spring Harbor Laboratory Press.
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