T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
16 06 2022
16 06 2022
Historique:
received:
14
09
2021
accepted:
07
06
2022
entrez:
17
6
2022
pubmed:
18
6
2022
medline:
22
6
2022
Statut:
epublish
Résumé
The immunological synapse is a molecular hub that facilitates the delivery of three activation signals, namely antigen, costimulation/corepression and cytokines, from antigen-presenting cells (APC) to T cells. T cells release a fourth class of signaling entities, trans-synaptic vesicles (tSV), to mediate bidirectional communication. Here we present bead-supported lipid bilayers (BSLB) as versatile synthetic APCs to capture, characterize and advance the understanding of tSV biogenesis. Specifically, the integration of juxtacrine signals, such as CD40 and antigen, results in the adaptive tailoring and release of tSV, which differ in size, yields and immune receptor cargo compared with steadily released extracellular vesicles (EVs). Focusing on CD40L
Identifiants
pubmed: 35710644
doi: 10.1038/s41467-022-31160-3
pii: 10.1038/s41467-022-31160-3
pmc: PMC9203538
doi:
Substances chimiques
CD40 Ligand
147205-72-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3460Subventions
Organisme : Wellcome Trust
ID : 091911
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 212343/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107457
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L018942/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100262Z/12/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203141/Z/16/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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