B Cells Are Required to Generate Optimal Anti-Melanoma Immunity in Response to Checkpoint Blockade.

Blymphocytes chemokineCXCL13 cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) immunotherapy knockout (KO) programmed death-ligand 1 (PD-L1) the Cancer Genome Atlas melanoma (TCGA) toll-like receptor 7/8

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 13 10 2021
accepted: 20 04 2022
entrez: 20 6 2022
pubmed: 21 6 2022
medline: 22 6 2022
Statut: epublish

Résumé

Immunotherapies such as checkpoint blockade therapies are known to enhance anti-melanoma CD8

Identifiants

pubmed: 35720386
doi: 10.3389/fimmu.2022.794684
pmc: PMC9204262
doi:

Substances chimiques

Antibodies 0
Toll-Like Receptor 7 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

794684

Subventions

Organisme : NCI NIH HHS
ID : P50 CA093459
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States

Informations de copyright

Copyright © 2022 Singh, Roszik, Saini, Singh, Bavisi, Wang, Vien, Yang, Kundu, Davis, Bover, Diab, Neelapu, Overwijk, Rai and Singh.

Déclaration de conflit d'intérêts

Author WO was employed by company Nektar Therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

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Auteurs

Shubhra Singh (S)

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Jason Roszik (J)

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Neeraj Saini (N)

Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Vipul Kumar Singh (VK)

Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX, United States.

Karishma Bavisi (K)

Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Zhiqiang Wang (Z)

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Long T Vien (LT)

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Zixi Yang (Z)

Department of Biostatistics, The University of Texas, Health Science Center, Houston, TX, United States.

Suprateek Kundu (S)

Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Richard E Davis (RE)

Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Laura Bover (L)

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Adi Diab (A)

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Sattva S Neelapu (SS)

Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Willem W Overwijk (WW)

Nektar Therapeutics, San Francisco, CA, United States.

Kunal Rai (K)

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Manisha Singh (M)

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

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Classifications MeSH