The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic Review.
endocrine disrupting chemicals
environment
health
thyroid
thyroid toxicity
triclosan
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
02
2022
accepted:
11
03
2022
entrez:
20
6
2022
pubmed:
21
6
2022
medline:
22
6
2022
Statut:
epublish
Résumé
Triclosan is an antibacterial agent suspected to disrupt the endocrine system. The aim of this study was to investigate the influence of triclosan on the human thyroid system through a systematic literature review of human studies. Eligibility criteria and method of analysis were registered at Prospero (registration number: CRD42019120984) before a systematic search was conducted in Pubmed and Embase in October 2020. Seventeen articles were found eligible for inclusion. Thirteen studies were observational, while four had a triclosan intervention. Participants consisted of pregnant women in eight studies, of men and non-pregnant women in seven studies and of chord samples/newborns/children/adolescents in six studies. The outcomes were peripheral thyroid hormones and thyroid-stimulating hormone (TSH) in blood samples. Several studies found a negative association between triclosan and triiodothyronine and thyroxine, and a positive association with TSH; however, the opposite associations or no associations were also found. In general, the studies had limited measurement timepoints of thyroid outcomes, and the interventional studies used low concentrations of triclosan. Thus, study design limitations influence the quality of the dataset and it is not yet possible to conclude whether triclosan at current human exposure levels adversely affects the thyroid hormone system. Further larger studies with more continuity and more elaborate outcome measurements of thyroid function are needed to clarify whether triclosan, at current exposure levels, affects the human thyroid hormone system. http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42019120984, identifier PROSPERO (CRD42019120984).
Identifiants
pubmed: 35721761
doi: 10.3389/fendo.2022.883827
pmc: PMC9202756
doi:
Substances chimiques
Thyroid Hormones
0
Triiodothyronine
06LU7C9H1V
Triclosan
4NM5039Y5X
Thyrotropin
9002-71-5
Thyroxine
Q51BO43MG4
Types de publication
Systematic Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
883827Informations de copyright
Copyright © 2022 Homburg, Rasmussen, Ramhøj and Feldt-Rasmussen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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