Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism.
Autism
Hyperserotonemia
Immunity
Whole blood serotonin
Journal
Journal of autism and developmental disorders
ISSN: 1573-3432
Titre abrégé: J Autism Dev Disord
Pays: United States
ID NLM: 7904301
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
accepted:
27
04
2022
pubmed:
22
6
2022
medline:
6
8
2022
entrez:
21
6
2022
Statut:
ppublish
Résumé
Hyperserotonemia, or elevated levels of whole blood serotonin (WB5-HT), was the first biomarker linked to autism spectrum disorder (ASD). Despite numerous studies investigating the etiology of hyperserotonemia, results have been inconsistent. Recent findings suggest a relationship between the immune system and hyperserotonemia. The current study investigated whether intestinal 5-HT levels, 5-HT gene expression, or intestinal cell types predict WB5-HT. Participants included thirty-one males aged 3-18 who were classified into one of three groups: ASD and functional GI issues, typically developing with GI issues, and typically developing without GI issues. Samples from a lower endoscopy were analyzed to examine the pathways in predicting WB-5HT. Results demonstrated an association between T-Lymphocytes and WB5-HT.
Identifiants
pubmed: 35726077
doi: 10.1007/s10803-022-05597-w
pii: 10.1007/s10803-022-05597-w
doi:
Substances chimiques
Biomarkers
0
Serotonin
333DO1RDJY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3780-3789Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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