German Cardiac Arrest Registry: rationale and design of G-CAR.
Cardiac arrest centre (CAC)
Cardiopulmonary resuscitation (CPR)
Extracorporeal cardiopulmonary resuscitation (eCPR)
Out-of-hospital cardiac arrest (OHCA)
Post-resuscitation care
Registry
Journal
Clinical research in cardiology : official journal of the German Cardiac Society
ISSN: 1861-0692
Titre abrégé: Clin Res Cardiol
Pays: Germany
ID NLM: 101264123
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
10
04
2022
accepted:
12
05
2022
medline:
30
3
2023
pubmed:
22
6
2022
entrez:
21
6
2022
Statut:
ppublish
Résumé
In Germany, 70,000-100,000 persons per year suffer from out-of-hospital cardiac arrest (OHCA). Despite medical progress, survival rates with good neurological outcome remain low. For many important clinical issues, no or only insufficient evidence from randomised trials is available. Therefore, a systemic and standardised acquisition of the treatment course and of the outcome of OHCA patients is warranted. The German Cardiac Arrest Registry (G-CAR) is an observational, prospective, multicentre registry. It will determine the characteristics, initial treatment strategies, invasive procedures, revascularisation therapies and the use of mechanical circulatory support devices with a focus on extracorporeal cardiopulmonary resuscitation. A special feature is the prospective 12-month follow-up evaluating mortality, neurological outcomes and several patient-reported outcomes in the psychosocial domain (health-related quality of life, cognitive impairment, depression/anxiety, post-traumatic stress disorder and social reintegration). In a pilot phase of 24 months, 15 centres will include approximately 400 consecutive OHCA patients ≥ 18 years. Parallel to and after the pilot phase, scaling up of G-CAR to a national level is envisaged. G-CAR is the first national registry including a long-term follow-up for adult OHCA patients. Primary aim is a better understanding of the determinants of acute and long-term outcomes with the perspective of an optimised treatment. NCT05142124. German Cardiac Arrest Registry (G-CAR).
Sections du résumé
BACKGROUND
BACKGROUND
In Germany, 70,000-100,000 persons per year suffer from out-of-hospital cardiac arrest (OHCA). Despite medical progress, survival rates with good neurological outcome remain low. For many important clinical issues, no or only insufficient evidence from randomised trials is available. Therefore, a systemic and standardised acquisition of the treatment course and of the outcome of OHCA patients is warranted.
STUDY DESIGN
METHODS
The German Cardiac Arrest Registry (G-CAR) is an observational, prospective, multicentre registry. It will determine the characteristics, initial treatment strategies, invasive procedures, revascularisation therapies and the use of mechanical circulatory support devices with a focus on extracorporeal cardiopulmonary resuscitation. A special feature is the prospective 12-month follow-up evaluating mortality, neurological outcomes and several patient-reported outcomes in the psychosocial domain (health-related quality of life, cognitive impairment, depression/anxiety, post-traumatic stress disorder and social reintegration). In a pilot phase of 24 months, 15 centres will include approximately 400 consecutive OHCA patients ≥ 18 years. Parallel to and after the pilot phase, scaling up of G-CAR to a national level is envisaged.
CONCLUSION
CONCLUSIONS
G-CAR is the first national registry including a long-term follow-up for adult OHCA patients. Primary aim is a better understanding of the determinants of acute and long-term outcomes with the perspective of an optimised treatment.
TRIAL REGISTRY
BACKGROUND
NCT05142124. German Cardiac Arrest Registry (G-CAR).
Identifiants
pubmed: 35729429
doi: 10.1007/s00392-022-02044-9
pii: 10.1007/s00392-022-02044-9
pmc: PMC10050030
doi:
Banques de données
ClinicalTrials.gov
['NCT05142124']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
455-463Subventions
Organisme : Dr. Rolf M. Schwiete Stiftung
ID : 2020-029
Organisme : Deutsche Stiftung für Herzforschung
ID : F/07/20
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022. The Author(s).
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