Efficacy of prophylactic platelet rich plasma (PRP) following open saphenous vein harvesting in cardiac surgery.

Coronary Artery Bypass / adverse effects Humans Platelet-Rich Plasma Retrospective Studies Saphenous Vein / transplantation Surgical Wound Infection / epidemiology
Platelet rich plasma coronary artery bypass graft surgical wound infection

Journal

Frontiers in bioscience (Elite edition)
ISSN: 1945-0508
Titre abrégé: Front Biosci (Elite Ed)
Pays: Singapore
ID NLM: 101485240

Informations de publication

Date de publication:
07 05 2022
Historique:
received: 21 12 2021
revised: 05 01 2022
accepted: 24 01 2022
entrez: 22 6 2022
pubmed: 23 6 2022
medline: 24 6 2022
Statut: ppublish

Résumé

Wound infection represents a frequent trouble following open saphenous vein harvesting in cardiac surgery. Platelets' growth factors are crucial for the healing process. Prophylactic platelet rich plasma (PRP) application on leg wound might reduce the incidence of saphenous vein harvest site infections in patients undergoing coronary artery bypass graft surgery (CABG). Between January 2009 and December 2020, 987 consecutive patients underwent CABG using saphenous vein as conduit graft and were retrospectively divided into two groups. All patients had standard surgical leg wound closure and wound care, but treatment group received adjunctive topical application of PRP (no-PRP and PRP group, respectively). The primary outcome was wound infection. Saphenous vein harvest site infection rate was similar between PRP (3.5%) and No-PRP (5.2%) group, Topical application of autologous PRP on saphenoug vein harvest site might reduce the rate of surgical site infection, with particular benefit among diabetic patients.

Sections du résumé

BACKGROUND
Wound infection represents a frequent trouble following open saphenous vein harvesting in cardiac surgery. Platelets' growth factors are crucial for the healing process. Prophylactic platelet rich plasma (PRP) application on leg wound might reduce the incidence of saphenous vein harvest site infections in patients undergoing coronary artery bypass graft surgery (CABG).
METHODS
Between January 2009 and December 2020, 987 consecutive patients underwent CABG using saphenous vein as conduit graft and were retrospectively divided into two groups. All patients had standard surgical leg wound closure and wound care, but treatment group received adjunctive topical application of PRP (no-PRP and PRP group, respectively). The primary outcome was wound infection.
RESULTS
Saphenous vein harvest site infection rate was similar between PRP (3.5%) and No-PRP (5.2%) group,
CONCLUSIONS
Topical application of autologous PRP on saphenoug vein harvest site might reduce the rate of surgical site infection, with particular benefit among diabetic patients.

Identifiants

DOI: 10.31083/j.fbe1402012 PMID: 35730453
pubmed: 35730453
pii: S1945-0494(22)00074-1
doi: 10.31083/j.fbe1402012
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

12

Informations de copyright

© 2022 The Author(s). Published by IMR Press.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Auteurs

Federica Jiritano (F)

Cardiac Surgery, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.

Raffaele Serra (R)

Vascular Surgery, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.

Antonio Nenna (A)

Cardiac Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.

Antonio Curcillo (A)

Cardiac Surgery, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.

Francesco Villella (F)

Cardiac Surgery, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.

Francesco Nappi (F)

Cardiac Surgery, Centre Cardiologique du Nord de Saint-Denis, 93200 Paris, France.

Camilla Chello (C)

PhD course in Integrated Biomedical Science and Bioethics, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.

Massimo Chello (M)

Cardiac Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.

Pasquale Mastroroberto (P)

Cardiac Surgery, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.

Giuseppe Filiberto Serraino (GF)

Cardiac Surgery, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie thoracique › Procédures de chirurgie cardiaque › Revascularisation myocardique › Pontage aortocoronarien › Efficacy of prophylactic platelet rich plasma...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Efficacy of prophylactic platelet rich plasma...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Plasma sanguin › Plasma riche en plaquettes › Efficacy of prophylactic platelet rich plasma...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Efficacy of prophylactic platelet rich plasma...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Veines › Veine saphène › Efficacy of prophylactic platelet rich plasma...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Infection de plaie opératoire › Efficacy of prophylactic platelet rich plasma...