Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
22 06 2022
22 06 2022
Historique:
entrez:
22
6
2022
pubmed:
23
6
2022
medline:
25
6
2022
Statut:
ppublish
Résumé
Prediction of hepatocellular carcinoma (HCC) risk is an urgent unmet need in patients with nonalcoholic fatty liver disease (NAFLD). In cohorts of 409 patients with NAFLD from multiple global regions, we defined and validated hepatic transcriptome and serum secretome signatures predictive of long-term HCC risk in patients with NAFLD. A 133-gene signature, prognostic liver signature (PLS)-NAFLD, predicted incident HCC over up to 15 years of longitudinal observation. High-risk PLS-NAFLD was associated with IDO1
Identifiants
pubmed: 35731891
doi: 10.1126/scitranslmed.abo4474
pmc: PMC9236162
mid: NIHMS1811543
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabo4474Subventions
Organisme : NCI NIH HHS
ID : R01 CA233794
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA255621
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099558
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA226052
Pays : United States
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