Prevention of Hypomineralization In Auditory Ossicles of Vitamin D Receptor (Vdr) Deficient Mice.

Animals Calcium Ear Ossicles Hearing Loss, Conductive Mice Mice, Knockout Minerals Receptors, Calcitriol / genetics
auditory ossicles hearing mineralization qBEI vitamin D receptor

Journal

Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782

Informations de publication

Date de publication:
2022
Historique:
received: 21 03 2022
accepted: 21 04 2022
entrez: 23 6 2022
pubmed: 24 6 2022
medline: 25 6 2022
Statut: epublish

Résumé

Intact mineralization of the auditory ossicles - the smallest bones in the body - is essential for sound transmission in the middle ear, while ossicular hypomineralization is associated with conductive hearing loss. Here, we performed a high-resolution analysis of the ossicles in vitamin D receptor deficient mice (

Identifiants

DOI: 10.3389/fendo.2022.901265 PMID: 35733772 PMC: PMC9207527
pubmed: 35733772
doi: 10.3389/fendo.2022.901265
pmc: PMC9207527
doi:

Substances chimiques

Minerals 0
Receptors, Calcitriol 0
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

901265

Informations de copyright

Copyright © 2022 Delsmann, Peichl, Yorgan, Beil, Amling, Demay and Rolvien.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Maximilian M Delsmann (MM)

Department of Trauma and Orthopaedic Surgery, Division of Orthopaedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Osteology and Biomechanics, University Medical Center Hamburg Eppendorf, Hamburg, Germany.

Jonathan Peichl (J)

Department of Otorhinolaryngology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Timur A Yorgan (TA)

Department of Osteology and Biomechanics, University Medical Center Hamburg Eppendorf, Hamburg, Germany.

Frank Timo Beil (FT)

Department of Trauma and Orthopaedic Surgery, Division of Orthopaedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Michael Amling (M)

Department of Osteology and Biomechanics, University Medical Center Hamburg Eppendorf, Hamburg, Germany.

Marie B Demay (MB)

Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Tim Rolvien (T)

Department of Trauma and Orthopaedic Surgery, Division of Orthopaedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Prevention of Hypomineralization In Auditory...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Prevention of Hypomineralization In Auditory...
questionsmedicales.fr › Organes des sens › Oreille › Oreille moyenne › Osselets de l'audition › Prevention of Hypomineralization In Auditory...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles de l'audition › Perte d'audition › Surdité de transmission › Prevention of Hypomineralization In Auditory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Prevention of Hypomineralization In Auditory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Prevention of Hypomineralization In Auditory...
questionsmedicales.fr › Produits chimiques inorganiques › Minéraux › Prevention of Hypomineralization In Auditory...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur calcitriol › Prevention of Hypomineralization In Auditory...