Nuclear hormone receptors in demyelinating diseases.
demyelination
hormone receptors
myelin
nuclear receptors
steroid hormones
Journal
Journal of neuroendocrinology
ISSN: 1365-2826
Titre abrégé: J Neuroendocrinol
Pays: United States
ID NLM: 8913461
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
20
04
2022
received:
21
01
2022
accepted:
27
05
2022
pubmed:
24
6
2022
medline:
30
7
2022
entrez:
23
6
2022
Statut:
ppublish
Résumé
Demyelination results from the pathological loss of myelin and is a hallmark of many neurodegenerative diseases. Despite the prevalence of demyelinating diseases, there are no disease modifying therapies that prevent the loss of myelin or promote remyelination. This review aims to summarize studies in the field that highlight the importance of nuclear hormone receptors in the promotion and maintenance of myelination and the relevance of nuclear hormone receptors as potential therapeutic targets for demyelinating diseases. These nuclear hormone receptors include the estrogen receptor, progesterone receptor, androgen receptor, vitamin D receptor, thyroid hormone receptor, peroxisome proliferator-activated receptor, liver X receptor, and retinoid X receptor. Pre-clinical studies in well-established animal models of demyelination have shown a prominent role of these nuclear hormone receptors in myelination through their promotion of oligodendrocyte maturation and development. The activation of the nuclear hormone receptors by their ligands also promotes the synthesis of myelin proteins and lipids in mouse models of demyelination. There are limited clinical studies that focus on how the activation of these nuclear hormone receptors could alleviate demyelination in patients with diseases such as multiple sclerosis (MS). However, the completed clinical trials have reported improved clinical outcome in MS patients treated with the ligands of some of these nuclear hormone receptors. Together, the positive results from both clinical and pre-clinical studies point to nuclear hormone receptors as promising therapeutic targets to counter demyelination.
Identifiants
pubmed: 35734821
doi: 10.1111/jne.13171
pmc: PMC9339486
mid: NIHMS1811705
doi:
Substances chimiques
Receptors, Cytoplasmic and Nuclear
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13171Subventions
Organisme : NCI NIH HHS
ID : R37 CA214800
Pays : United States
Informations de copyright
© 2022 British Society for Neuroendocrinology.
Références
J Neuroimmunol. 2015 Sep 15;286:48-58
pubmed: 26298324
Bioorg Med Chem Lett. 2011 Jan 1;21(1):240-4
pubmed: 21112784
J Clin Invest. 1993 Mar;91(3):812-8
pubmed: 7680668
Int J Mol Med. 2000 Jul;6(1):73-81
pubmed: 10851270
Sci Rep. 2019 Jan 24;9(1):503
pubmed: 30679747
Mol Cell Biol. 2000 Jul;20(14):5119-28
pubmed: 10866668
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2907-11
pubmed: 11867729
Recent Prog Horm Res. 2002;57:339-55
pubmed: 12017551
Proc Natl Acad Sci U S A. 1968 Feb;59(2):632-8
pubmed: 5238991
J Neurol Sci. 2011 Dec 15;311(1-2):23-31
pubmed: 21723567
J Biol Chem. 1997 Aug 8;272(32):20108-17
pubmed: 9242684
Neuroscience. 2007 Jun 8;146(4):1726-33
pubmed: 17449186
PPAR Res. 2010;2010:
pubmed: 20814433
Cells. 2020 Apr 14;9(4):
pubmed: 32295179
Exp Neurol. 2015 Sep;271:506-14
pubmed: 26210873
J Steroid Biochem Mol Biol. 2017 May;169:61-68
pubmed: 26940358
Cell Mol Life Sci. 2004 Feb;61(4):393-416
pubmed: 14999402
Neuroscience. 2015 Dec 3;310:224-41
pubmed: 26383254
Int J Mol Sci. 2020 Apr 30;21(9):
pubmed: 32365806
J Neurol Sci. 2009 Nov 15;286(1-2):114-8
pubmed: 19758607
Cell Mol Neurobiol. 1996 Apr;16(2):143-54
pubmed: 8743966
J Biol Chem. 1974 Feb 25;249(4):1251-7
pubmed: 4360685
Neurosci Lett. 2010 Jan 14;468(3):178-82
pubmed: 19853640
J Neurosci. 2008 Sep 17;28(38):9519-24
pubmed: 18799683
Neuroendocrinology. 2003 May;77(5):334-40
pubmed: 12806179
Vascul Pharmacol. 2002 Apr;38(4):249-56
pubmed: 12449021
Endocrinology. 2008 Jan;149(1):208-18
pubmed: 17962344
J Neurosci Res. 2003 May 15;72(4):425-35
pubmed: 12704804
J Chem Neuroanat. 2005 Jan;29(1):21-30
pubmed: 15589699
Glia. 2010 Nov 1;58(14):1669-85
pubmed: 20578043
Adv Protein Chem Struct Biol. 2019;116:135-170
pubmed: 31036290
Mol Endocrinol. 2006 Jun;20(6):1447-61
pubmed: 16574738
Front Neurosci. 2012 Feb 08;6:10
pubmed: 22347156
J Alzheimers Dis. 2020;73(3):1085-1103
pubmed: 31884472
PLoS One. 2011;6(10):e26262
pubmed: 22028844
J Bone Miner Res. 2015 Jan;30(1):128-36
pubmed: 25043694
Neurology. 2017 Jan 3;88(1):44-51
pubmed: 27903815
Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7587-92
pubmed: 26023184
Lipids. 2002 May;37(5):495-500
pubmed: 12056592
Steroids. 2016 Jan;105:19-25
pubmed: 26639431
J Mol Endocrinol. 2010 Jan;44(1):13-23
pubmed: 19578096
Indian J Urol. 2014 Jan;30(1):2-7
pubmed: 24497673
J Neuroimmunol. 2005 Nov;168(1-2):65-75
pubmed: 16098614
Endocr Rev. 2007 Dec;28(7):778-808
pubmed: 17940184
J Cell Physiol. 2008 Nov;217(2):367-76
pubmed: 18543250
Oncotarget. 2017 Jan 24;8(4):6283-6294
pubmed: 28009983
J Immunol. 2006 Apr 1;176(7):4385-98
pubmed: 16547277
Neuroscience. 2006;138(3):851-8
pubmed: 16343790
Brain Res. 1997 Mar 28;752(1-2):285-93
pubmed: 9106469
Neuron. 1998 Dec;21(6):1353-61
pubmed: 9883728
Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14829-14834
pubmed: 27930320
Endocrinology. 2012 Feb;153(2):837-46
pubmed: 22186418
Genes Immun. 2002 Apr;3(2):59-70
pubmed: 11960303
Glia. 2008 Jul;56(9):954-62
pubmed: 18383345
Cell. 1995 Dec 15;83(6):835-9
pubmed: 8521507
Growth Horm IGF Res. 2004 Jun;14 Suppl A:S18-33
pubmed: 15135772
ASN Neuro. 2010 Jan 15;2(1):e00025
pubmed: 20001953
Int J Cancer. 2013 Jan 15;132(2):417-26
pubmed: 22553145
Exp Neurol. 2011 Sep;231(1):72-81
pubmed: 21684276
Mol Cell Endocrinol. 2012 Jun 24;357(1-2):18-29
pubmed: 21952082
PLoS One. 2016 Jun 29;11(6):e0157754
pubmed: 27355629
Front Neurosci. 2013 Sep 03;7:157
pubmed: 24027494
Glia. 2009 Jun;57(8):884-97
pubmed: 19053058
BioDrugs. 2007;21(2):117-24
pubmed: 17402795
Int J Mol Sci. 2018 Oct 26;19(11):
pubmed: 30373124
Arch Neurol. 2007 May;64(5):683-8
pubmed: 17502467
Clin Chim Acta. 2006 Oct;372(1-2):33-42
pubmed: 16697362
Pharmacol Ther. 2011 Jul;131(1):33-9
pubmed: 21504761
Endocrinology. 2012 Feb;153(2):759-69
pubmed: 22147012
J Mol Endocrinol. 2001 Aug;27(1):1-9
pubmed: 11463572
Glia. 2015 Jan;63(1):104-17
pubmed: 25092805
J Steroid Biochem Mol Biol. 2016 Jun;160:43-52
pubmed: 26776441
Front Neuroendocrinol. 2012 Jan;33(1):105-15
pubmed: 22209870
Neuropsychiatr Dis Treat. 2015 Aug 25;11:2217-23
pubmed: 26346368
Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):266-71
pubmed: 9874807
Med Hypotheses. 1986 Oct;21(2):193-200
pubmed: 3537648
Neuroscience. 1993 Dec;57(3):861-71
pubmed: 7508580
Endocrinology. 2004 Nov;145(11):5021-32
pubmed: 15256495
J Clin Endocrinol Metab. 2004 Jul;89(7):3117-28
pubmed: 15240580
Immunology. 2010 Aug;130(4):572-88
pubmed: 20406305
Neurosci Lett. 2000 Jul 7;288(1):29-32
pubmed: 10869808
J Steroid Biochem Mol Biol. 2017 Oct;173:93-99
pubmed: 28330721
Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1673-8
pubmed: 14747651
Expert Rev Neurother. 2011 Apr;11(4):467-8
pubmed: 21469916
Lancet Neurol. 2016 Jan;15(1):35-46
pubmed: 26621682
Biochem Genet. 2021 Feb;59(1):1-30
pubmed: 33159645
Annu Rev Physiol. 2000;62:439-66
pubmed: 10845098
Sci Rep. 2017 Apr 04;7:45926
pubmed: 28374837
Neurobiol Dis. 2013 Aug;56:131-44
pubmed: 23603111
PLoS One. 2013 Aug 19;8(8):e71538
pubmed: 23977068
Pharmacol Res. 2020 Oct;160:105064
pubmed: 32634582
J Biol Chem. 2001 Aug 10;276(32):29681-7
pubmed: 11397807
Steroids. 2003 Nov;68(10-13):771-8
pubmed: 14667967
Prog Brain Res. 2009;175:239-51
pubmed: 19660660
Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16363-8
pubmed: 15534218
Diabetes. 1997 Aug;46(8):1319-27
pubmed: 9231657
Int J Mol Sci. 2019 Apr 16;20(8):
pubmed: 30995757
Gene. 2015 Mar 15;559(1):73-6
pubmed: 25595352
Stroke. 2015 Sep;46(9):2628-36
pubmed: 26243225
Nat Rev Endocrinol. 2018 Aug;14(8):452-463
pubmed: 29904174
J Neuroendocrinol. 2018 Feb;30(2):
pubmed: 28675779
J Lipid Res. 1996 May;37(5):907-25
pubmed: 8725145
Front Endocrinol (Lausanne). 2019 Oct 25;10:725
pubmed: 31708873
Int J Mol Sci. 2019 Aug 08;20(16):
pubmed: 31398791
Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59
pubmed: 17315033
Front Neuroendocrinol. 2009 Jul;30(2):173-87
pubmed: 19318112
Endocrinology. 1996 Jan;137(1):354-66
pubmed: 8536636
Ann Neurol. 2010 Aug;68(2):193-203
pubmed: 20695012
J Cell Biol. 2015 Dec 7;211(5):975-85
pubmed: 26644513
Exp Cell Res. 1991 Mar;193(1):12-9
pubmed: 1995287
Metab Brain Dis. 2012 Mar;27(1):29-35
pubmed: 21994003
Ann Endocrinol (Paris). 2008 Apr;69(2):157-9
pubmed: 18430408
Mult Scler. 2014 Oct;20(12):1584-92
pubmed: 24710799
J Biol Chem. 1997 Jul 25;272(30):18779-89
pubmed: 9228052
Immunology. 2019 Jan;156(1):9-22
pubmed: 30222193
Exp Neurol. 2020 Dec;334:113462
pubmed: 32916173
Neuroscience. 2009 Dec 29;164(4):1407-21
pubmed: 19800949
Microb Pathog. 2017 Sep;110:594-602
pubmed: 28780323
N Engl J Med. 1994 Sep 29;331(13):847-53
pubmed: 8078532
Brain. 2011 Sep;134(Pt 9):2703-21
pubmed: 21908875
J Steroid Biochem Mol Biol. 2017 Jan;165(Pt B):421-429
pubmed: 27597394
J Neurosci. 2003 Jul 2;23(13):5771-7
pubmed: 12843281
Trends Endocrinol Metab. 2002 Apr;13(3):100-5
pubmed: 11893522
Sci Rep. 2019 May 1;9(1):6749
pubmed: 31043642
Eur J Pediatr. 2008 Jul;167(7):785-91
pubmed: 17899191
Biochem Biophys Res Commun. 2002 Jan 11;290(1):230-5
pubmed: 11779158
Eur J Cancer. 2009 Nov;45(17):2940-6
pubmed: 19683429
J Immunol. 2003 Dec 1;171(11):5743-50
pubmed: 14634082
J Headache Pain. 2020 Nov 10;21(1):131
pubmed: 33167864
Future Med Chem. 2015;7(18):2411-3
pubmed: 26653291
Drugs Aging. 1999 May;14(5):347-57
pubmed: 10408735
Basic Res Cardiol. 2018 Aug 21;113(5):40
pubmed: 30132266
Ann Neurol. 2002 Oct;52(4):421-8
pubmed: 12325070
Neurochem Res. 2004 May;29(5):903-22
pubmed: 15139289
Cell Death Differ. 2004 Dec;11 Suppl 2:S126-43
pubmed: 15608692
Mult Scler Relat Disord. 2021 May;50:102801
pubmed: 33636616
Prog Neurobiol. 2008 Aug;85(4):433-51
pubmed: 18554773
J Neuroinflammation. 2017 Jul 28;14(1):151
pubmed: 28754131
Reprod Med Biol. 2016 Dec 05;16(1):4-20
pubmed: 29259445
Mol Cell Endocrinol. 2011 Dec 5;347(1-2):3-10
pubmed: 21664239
J Mol Endocrinol. 2020 Jul;65(1):T49-T63
pubmed: 32485679
Mol Cell Biol. 2003 Nov;23(21):7678-88
pubmed: 14560013
ACS Chem Biol. 2018 Dec 21;13(12):3269-3278
pubmed: 30398845
Cell Mol Neurobiol. 2010 Mar;30(2):289-99
pubmed: 19768531
Mult Scler. 2002 Dec;8(6):452-8
pubmed: 12474982
Horm Behav. 2008 May;53(5):753-64
pubmed: 18402960
Genes Dev. 1995 May 1;9(9):1033-45
pubmed: 7744246
Nutrients. 2016 Mar 02;8(3):135
pubmed: 26950144
Glia. 2001 Mar 1;33(3):191-204
pubmed: 11241737
Biochim Biophys Acta. 2012 Jan;1821(1):21-56
pubmed: 22020178
Biol Sex Differ. 2021 Mar 8;12(1):25
pubmed: 33685490
EMBO J. 2003 Sep 15;22(18):4625-33
pubmed: 12970175
Front Neuroendocrinol. 2009 Jul;30(2):130-41
pubmed: 19393684
Free Radic Biol Med. 2014 Aug;73:41-50
pubmed: 24794409
Glia. 2009 Jun;57(8):807-14
pubmed: 19031445
Front Neurosci. 2019 May 17;13:503
pubmed: 31156378
Arterioscler Thromb Vasc Biol. 2002 May 1;22(5):717-26
pubmed: 12006382
Annu Rev Med. 2002;53:409-35
pubmed: 11818483
Neurologia (Engl Ed). 2018 Apr;33(3):177-186
pubmed: 27321170
Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):18061-6
pubmed: 25453074
EMBO Rep. 2003 Feb;4(2):137-42
pubmed: 12612601
J Atheroscler Thromb. 2009 Aug;16(4):303-18
pubmed: 19672026
Genome Res. 2010 Oct;20(10):1352-60
pubmed: 20736230
Neurology. 2006 Jan 24;66(2):182-6
pubmed: 16434650
Chem Biol. 1995 May;2(5):261-6
pubmed: 9383428
Endocrinology. 2021 Aug 1;162(8):
pubmed: 33939822
Mol Cell Endocrinol. 2010 Feb 5;315(1-2):19-26
pubmed: 19765631
J Neurosci. 2009 Apr 8;29(14):4461-70
pubmed: 19357272
J Neurosci Res. 1987;17(3):220-4
pubmed: 2439700
Dev Biol. 2001 Jul 1;235(1):110-20
pubmed: 11412031
J Endocrinol Invest. 2013 Jun;36(6):435-43
pubmed: 23609963
J Neurosci. 2001 Aug 15;21(16):6221-32
pubmed: 11487645
J Neurol Sci. 2009 Nov 15;286(1-2):99-103
pubmed: 19539954
J Biol Chem. 2012 Oct 5;287(41):34134-48
pubmed: 22879602
J Steroid Biochem Mol Biol. 1996 Jan;56(1-6 Spec No):67-77
pubmed: 8603049
Neuroscience. 2014 May 30;268:1-9
pubmed: 24607320
Heart Fail Rev. 2010 Mar;15(2):177-82
pubmed: 19002578
Acupunct Med. 2017 Apr;35(2):122-132
pubmed: 27841975
J Immunol. 2005 Sep 15;175(6):4119-26
pubmed: 16148162
J Bone Miner Res. 1999 Jul;14(7):1163-6
pubmed: 10404016
Int Immunopharmacol. 2017 Oct;51:131-139
pubmed: 28830026
J Clin Invest. 2020 May 1;130(5):2220-2236
pubmed: 32202512
Brain Behav. 2020 Jan;10(1):e01498
pubmed: 31837111
Nature. 2006 Nov 23;444(7118):486-9
pubmed: 17108970
Phytomedicine. 2021 Oct;91:153677
pubmed: 34333329
Ann Neurol. 2002 Jun;51(6):694-702
pubmed: 12112074
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2160-4
pubmed: 8384714
Endocrinology. 1980 Jan;106(1):306-16
pubmed: 7349961
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10459-64
pubmed: 9724725
J Neuropathol Exp Neurol. 2009 Jul;68(7):797-808
pubmed: 19535992
EMBO J. 2002 Dec 2;21(23):6452-60
pubmed: 12456652
J Cell Biol. 1993 Apr;121(2):423-38
pubmed: 8385673
Ther Adv Drug Saf. 2014 Oct;5(5):190-200
pubmed: 25360240
Cell Rep. 2015 Feb 3;10(4):516-26
pubmed: 25620699
Biochemistry. 1993 Jun 1;32(21):5598-604
pubmed: 7684926
Front Neuroendocrinol. 2019 Oct;55:100788
pubmed: 31513776
Neuron Glia Biol. 2006 Nov;2(4):227-34
pubmed: 18049715
Brain. 2013 Jan;136(Pt 1):132-46
pubmed: 23365095
J Steroid Biochem Mol Biol. 2004 Feb;88(2):113-22
pubmed: 15084343
Clin Neurol Neurosurg. 2006 Mar;108(3):266-70
pubmed: 16413965
Neurology. 2008 Jul 8;71(2):129-35
pubmed: 18606967
J Chem Neuroanat. 1999 Feb;16(2):135-45
pubmed: 10223312
J Neural Eng. 2017 Jun;14(3):036014
pubmed: 28358726
Neurosci Lett. 2021 Apr 17;750:135764
pubmed: 33621639
Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):59-63
pubmed: 15913974
J Neuroimmunol. 2006 Sep;178(1-2):76-86
pubmed: 16844232
PLoS One. 2017 Jan 6;12(1):e0169643
pubmed: 28060907
J Neurochem. 1998 Apr;70(4):1366-75
pubmed: 9523552
Neuroreport. 1994 Sep 8;5(14):1805-8
pubmed: 7827337
Exp Neurol. 2008 Aug;212(2):458-67
pubmed: 18572165
Epidemiol Rev. 1993;15(1):98-107
pubmed: 8405216
J Physiol Pharmacol. 2008 Dec;59 Suppl 7:31-55
pubmed: 19258656
Glia. 2010 Sep;58(12):1451-64
pubmed: 20648638
Trials. 2020 Jun 29;21(1):591
pubmed: 32600454
Biol Sex Differ. 2016 Aug 24;7(1):36
pubmed: 27559466
Front Immunol. 2018 Mar 12;9:477
pubmed: 29593729
J Geriatr Psychiatry Neurol. 2009 Sep;22(3):188-95
pubmed: 19073839
J Steroid Biochem Mol Biol. 2016 Nov;164:265-270
pubmed: 26323657
J Steroid Biochem Mol Biol. 2020 May;199:105606
pubmed: 31981800
J Steroid Biochem Mol Biol. 2016 Nov;164:246-253
pubmed: 26369615
Neuroimage Clin. 2014 Mar 06;4:454-60
pubmed: 24634831
Nat Med. 2013 May;19(5):557-66
pubmed: 23652116
J Lipid Res. 2019 Jul;60(7):1190-1198
pubmed: 31085627
Rev Neurol (Paris). 2006 Mar;162(3):299-309
pubmed: 16585885
J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):59-65
pubmed: 21041201
Nat Neurosci. 2011 Jan;14(1):45-53
pubmed: 21131950
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13878-83
pubmed: 12368482
Exp Biol Med (Maywood). 2015 Sep;240(9):1183-96
pubmed: 25577802
J Exp Med. 2010 Aug 2;207(8):1599-608
pubmed: 20624891
Mult Scler. 2018 Mar;24(3):279-289
pubmed: 28273782
Mol Cell Biol. 1991 Oct;11(10):5005-15
pubmed: 1922030
Endocrinology. 2014 Apr;155(4):1418-27
pubmed: 24476134
Expert Rev Clin Immunol. 2021 Jul;17(7):691-693
pubmed: 33836645
Front Physiol. 2019 Mar 05;10:194
pubmed: 30890957
Glia. 2003 Jan;41(1):3-14
pubmed: 12465041
J Endocrinol. 2014 Jul;222(1):53-60
pubmed: 24824431
J Comp Neurol. 2021 Jun;529(9):2362-2375
pubmed: 33368246
J Neurol. 2021 Jan;268(1):30-44
pubmed: 31190170
Exp Mol Pathol. 2017 Jun;102(3):515-521
pubmed: 28552332
Front Pharmacol. 2018 Oct 09;9:1026
pubmed: 30356713
Am J Transl Res. 2016 Feb 15;8(2):1016-26
pubmed: 27158387
Dev Neurosci. 2004 Mar-Aug;26(2-4):245-54
pubmed: 15711064
Trends Endocrinol Metab. 2016 Jun;27(6):404-414
pubmed: 27113081
Chem Rev. 2005 Sep;105(9):3352-70
pubmed: 16159155
Annu Rev Med. 2006;57:313-29
pubmed: 16409152
Vitam Horm. 2020;114:145-165
pubmed: 32723542
Am J Hum Genet. 1989 Feb;44(2):264-9
pubmed: 2563196
Vitam Horm. 2002;65:345-76
pubmed: 12481554
J Neurosci Res. 1998 Mar 1;51(5):563-73
pubmed: 9512000
Science. 1967 Oct 27;158(3800):529-30
pubmed: 17749092
J Immunol. 2001 Aug 15;167(4):2060-7
pubmed: 11489988
Cold Spring Harb Perspect Biol. 2013 Mar 01;5(3):a016709
pubmed: 23457262