Progressive myelin oligodendrocyte glycoprotein-associated demyelination mimicking leukodystrophy.
MOGAD
myelin oligodendrocyte glycoprotein antibody-associated disease
neuroinflammation
neuromyelitis optica
progressive
progressive MOGAD
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
pubmed:
24
6
2022
medline:
8
7
2022
entrez:
23
6
2022
Statut:
ppublish
Résumé
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) may be associated with relapsing disease, but clinical progression independent of relapse activity is rare. To report progressive disease in a patient with MOGAD. A single retrospective case report. At 4 years of age, the patient had a single episode of acute disseminated encephalomyelitis. She remained well until age 17 years but over the next 9 years developed progressive spastic quadriparesis, cognitive and bulbar dysfunction. Brain imaging showed a leukodystrophy-like pattern of white matter abnormality with contrast enhancement at different time points. Myelin oligodendrocyte glycoprotein (MOG)-IgG was repeatedly positive by live cell-based assay. Secondary progression may be a rare presentation of MOG-IgG-associated disease.
Sections du résumé
BACKGROUND
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) may be associated with relapsing disease, but clinical progression independent of relapse activity is rare.
OBJECTIVES
To report progressive disease in a patient with MOGAD.
METHODS
A single retrospective case report.
RESULTS
At 4 years of age, the patient had a single episode of acute disseminated encephalomyelitis. She remained well until age 17 years but over the next 9 years developed progressive spastic quadriparesis, cognitive and bulbar dysfunction. Brain imaging showed a leukodystrophy-like pattern of white matter abnormality with contrast enhancement at different time points. Myelin oligodendrocyte glycoprotein (MOG)-IgG was repeatedly positive by live cell-based assay.
CONCLUSION
Secondary progression may be a rare presentation of MOG-IgG-associated disease.
Identifiants
pubmed: 35735077
doi: 10.1177/13524585221090737
doi:
Substances chimiques
Aquaporin 4
0
Autoantibodies
0
Immunoglobulin G
0
Myelin-Oligodendrocyte Glycoprotein
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1481-1484Commentaires et corrections
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