Global REACH 2018: increased adrenergic restraint of blood flow preserves coupling of oxygen delivery and demand during exercise at high-altitude.
blood flow
exercise hyperaemia
high-altitude
hypoxia
sympathetic nervous system
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
13
02
2022
accepted:
16
06
2022
pubmed:
24
6
2022
medline:
3
8
2022
entrez:
23
6
2022
Statut:
ppublish
Résumé
Chronic exposure to hypoxia (high-altitude, HA; >4000 m) attenuates the vasodilatory response to exercise and is associated with a persistent increase in basal sympathetic nerve activity (SNA). The mechanism(s) responsible for the reduced vasodilatation and exercise hyperaemia at HA remains unknown. We hypothesized that heightened adrenergic signalling restrains skeletal muscle blood flow during handgrip exercise in lowlanders acclimatizing to HA. We tested nine adult males (n = 9) at sea-level (SL; 344 m) and following 21-28 days at HA (∼4300 m). Forearm blood flow (FBF; duplex ultrasonography), mean arterial pressure (MAP; brachial artery catheter), forearm vascular conductance (FVC; FBF/MAP), and arterial and venous blood sampling (O
Identifiants
pubmed: 35738560
doi: 10.1113/JP282972
pmc: PMC9357095
mid: NIHMS1818568
doi:
Substances chimiques
Adrenergic Agents
0
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3483-3495Subventions
Organisme : NHLBI NIH HHS
ID : F32 HL137285
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2022 The Authors. The Journal of Physiology © 2022 The Physiological Society.
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