Metabolomic Profiling of Angiotensin-II-Induced Abdominal Aortic Aneurysm in Ldlr
Angiotensin II
/ metabolism
Animals
Aorta, Abdominal
/ metabolism
Aortic Aneurysm, Abdominal
/ metabolism
Disease Models, Animal
Energy Metabolism
Glutamine
/ metabolism
Glycine
/ metabolism
Hypercholesterolemia
/ metabolism
Hyperlipidemias
/ metabolism
Lipids
Metabolomics
Mice
Mice, Inbred C57BL
Nitric Oxide
/ metabolism
Receptors, LDL
/ metabolism
aneurysm
aorta
blood flow
hypertension
lipidomics
metabolomics
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Jun 2022
07 Jun 2022
Historique:
received:
20
04
2022
revised:
28
05
2022
accepted:
03
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
Aneurysm is the second-most common disease affecting the aorta worldwide after atherosclerosis. While several clinical metabolomic studies have been reported, no study has reported deep metabolomic phenotyping in experimental animal models of aortic aneurysm. We performed a targeted metabolomics study on the blood and aortas of an experimental mice model of aortic aneurysm generated by high-cholesterol diet and angiotensin II in Ldlr
Identifiants
pubmed: 35742839
pii: ijms23126387
doi: 10.3390/ijms23126387
pmc: PMC9223449
pii:
doi:
Substances chimiques
Lipids
0
Receptors, LDL
0
Glutamine
0RH81L854J
Angiotensin II
11128-99-7
Nitric Oxide
31C4KY9ESH
Glycine
TE7660XO1C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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