Serotonin Receptors as Therapeutic Targets for Autism Spectrum Disorder Treatment.
autism spectrum disorders
modulators
serotonin receptors
therapeutic targets
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Jun 2022
10 Jun 2022
Historique:
received:
18
05
2022
revised:
08
06
2022
accepted:
08
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by repetitive and stereotyped behaviors as well as difficulties with social interaction and communication. According to reports for prevalence rates of ASD, approximately 1~2% of children worldwide have been diagnosed with ASD. Although there are a couple of FDA (Food and Drug Administration)-approved drugs for ASD treatment such as aripiprazole and risperidone, they are efficient for alleviating aggression, hyperactivity, and self-injury but not the core symptoms. Serotonin (5-hydroxytryptamine, 5-HT) as a neurotransmitter plays a crucial role in the early neurodevelopmental stage. In particular, 5-HT has been known to regulate a variety of neurobiological processes including neurite outgrowth, dendritic spine morphology, shaping neuronal circuits, synaptic transmission, and synaptic plasticity. Given the roles of serotonergic systems, the 5-HT receptors (5-HTRs) become emerging as potential therapeutic targets in the ASD. In this review, we will focus on the recent development of small molecule modulators of 5-HTRs as therapeutic targets for the ASD treatment.
Identifiants
pubmed: 35742963
pii: ijms23126515
doi: 10.3390/ijms23126515
pmc: PMC9223717
pii:
doi:
Substances chimiques
Receptors, Serotonin
0
Serotonin
333DO1RDJY
Aripiprazole
82VFR53I78
Risperidone
L6UH7ZF8HC
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2022R1C1C1006143
Organisme : National Research Foundation of Korea
ID : NRF-2021R1A2C2006244
Organisme : Korea Institute of Science and Technology
ID : 2E31512
Organisme : Korea Institute of Science and Technology
ID : 2E31523
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