Design and Synthesis of Menthol and Thymol Derived Ciprofloxacin: Influence of Structural Modifications on the Antibacterial Activity and Anticancer Properties.
Anti-Bacterial Agents
/ chemistry
Anti-Infective Agents
/ pharmacology
Antineoplastic Agents
/ chemistry
Ciprofloxacin
/ chemistry
DNA Gyrase
/ metabolism
Menthol
/ pharmacology
Microbial Sensitivity Tests
Molecular Docking Simulation
Staphylococcus aureus
/ metabolism
Structure-Activity Relationship
Thymol
/ pharmacology
Ciprofloxacin
antibiotic
antimicrobial
menthol
thymol
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Jun 2022
13 Jun 2022
Historique:
received:
11
05
2022
revised:
09
06
2022
accepted:
10
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
Sixteen new Ciprofloxacin derivatives were designed and successfully synthesized. In an in silico experiment, lipophilicity was established for obtained compounds. All compounds were screened for antimicrobial activity using standard and clinical strains. As for Gram-positive hospital microorganisms, all tested derivatives were active. Measured MICs were in the range 1-16 µg/mL, confirming high antimicrobial potency. Derivative
Identifiants
pubmed: 35743043
pii: ijms23126600
doi: 10.3390/ijms23126600
pmc: PMC9224473
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Antineoplastic Agents
0
Menthol
1490-04-6
Thymol
3J50XA376E
Ciprofloxacin
5E8K9I0O4U
DNA Gyrase
EC 5.99.1.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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