Eyelid sebaceous gland carcinoma, validation of AJCC 8th edition T staging- a retrospective study from North India.
AJCC staging 8th edition
T category
eyelid
prognosis
sebaceous gland carcinoma
Journal
Acta ophthalmologica
ISSN: 1755-3768
Titre abrégé: Acta Ophthalmol
Pays: England
ID NLM: 101468102
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
revised:
20
05
2022
received:
26
05
2021
accepted:
31
05
2022
pubmed:
26
6
2022
medline:
25
1
2023
entrez:
25
6
2022
Statut:
ppublish
Résumé
This study compares the 8th edition staging of AJCC for prognosis of eyelid Sebaceous Gland Carcinoma (SGC) patients with respect to the 7th edition. A retrospective study was undertaken over a period of 100 months. Ninety-nine histopathologically proven cases of eyelid SGC available for follow-up were recruited. Patients were staged by both the 7th and 8th editions of AJCC and followed up at six monthly intervals after surgery. Of the 99 eyelid SGC patients recruited, recurrence and orbital invasion developed in 22%, lymph node metastasis in 21% and 4% had distant metastasis and also died. High-risk features include tumour size>20 mm, orbital invasion, exenteration and staging by both the 7th and 8th editions of AJCC. Cox regression analysis revealed that staging by AJCC 8th edition was associated with greater risk for local recurrence (HR 3.01,95% CI-1.65-5.51%, p < 0.01) lymph node metastasis (HR 8.26, 95% CI 3.96-17.19%, p < 0.01) and disease-free survival (HR 4.61, 95% CI 2.81-7.54). The Kaplan-Meir survival curves of eyelid SGC patients by the 8th edition AJCC staging were also significantly associated with lymph node metastasis (p < 0.01), tumour-related deaths (p < 0.01) and reduced disease-free survival (p = 0.07). The higher Harrell's values by the 8th edition signify better predictive value for lymph node metastasis and DFS (disease-free survival). The lower AIC values indicate a better monotonicity of gradients for lymph node metastasis, recurrence and DFS. Staging by the 8th AJCC edition is, therefore, recommended for eyelid SGC as it gives a better perspective about disease outcome. The orbital extension was the single most important predictor of lymph node metastasis, recurrence and death.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
49-56Informations de copyright
© 2022 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
Références
Ainbinder, D.J., Esmaeli, B., Groo, S.C., Finger, P.T. & Brooks, J.P. (2009) Introduction of the 7th edition eyelid carcinoma classification system from the American joint committee on cancer-International Union against Cancer staging manual. Archives of Pathology & Laboratory Medicine, 133, 1256-1261.
Domingo-Musibay, E., Murugan, P., Giubellino, A., Sharma, S., Steinberger, D., Yuan, J. et al. (2018) Near complete response to pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma. Journal for ImmunoTherapy of Cancer, 6, 58.
Esmaeli, B., Nasser, Q.J., Cruz, H., Fellman, M., Warneke, C.L. & Ivan, D. (2012) American joint committee on cancer T category for eyelid sebaceous carcinoma correlates with nodal metastasis and survival. Ophthalmology, 119, 1078-1082.
Esmaeli, B., Dutton, J.J. & Graue, G.F. (2017) Ophthalmic sites: carcinoma of the eyelid. In: ES, A.M.B., Greene, F.L. & Byrd, D.R. (Eds.) AJCC cancer staging manual, 8th edition. New York: Springer, pp. 779-786.
Hsia, Y., Yeh, C.Y., Wei, Y.H., Chen, L.W. & Liao, S.L. (2019) Eyelid sebaceous carcinoma: validation of the 8th edition of the American joint committee on cancer T staging system and the prognostic factors for local recurrence, nodal metastasis, and survival. Eye, 33, 887-895.
Kaliki, S., Gupta, A., Ali, M.H., Ayyar, A. & Naik, M.N. (2016) Prognosis of eyelid sebaceous gland carcinoma based on the tumor (T) category of the American joint committee on cancer (AJCC) classification. International Ophthalmology, 36, 681-690.
Mulay, K., Aggarwal, E. & White, V.A. (2013) Periocular sebaceous gland carcinoma: a comprehensive review. Saudi Journal of Ophthalmology, 27, 159-165.
Knackstedt, T. & Samie, F.H. (2017) Sebaceous carcinoma: a review of the scientific literature. Current Treatment Options in Oncology, 18, 47.
Lam, S.C., Li, E.Y.M. & Yuen, H.K.L. (2018) 14-year case series of eyelid sebaceous gland carcinoma in Chinese patients and review of management. British Journal of Ophthalmology, 102, 1723-1727.
Margo, C.E. (2020) Periocular intraepithelial sebaceous neoplasia: critical appraisal of nomenclature and prognostic importance. Journal of Clinical Pathology, 73, 172-175.
Muqit, M., Roberts, F., Lee, W. & Kemp, E. (2004) Improved survival rates in sebaceous carcinoma of the eyelid. Eye, 18, 49-53.
R Core Team (2021). R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. Available from: https://www.R-project.org/
Sa, H.-S., Rubin, M.L., Xu, S., Ning, J., Tetzlaff, M., Sagiv, O. et al. (2019) Prognostic factors for local recurrence, metastasis and survival for sebaceous carcinoma of the eyelid: observations in 100 patients. British Journal of Ophthalmology, 103, 980-984.
Wali, U.K. & Al-Mujaini, A. (2010) Sebaceous gland carcinoma of the eyelid. Oman Journal of Ophthalmology, 3, 117-121.
Watanabe, A., Sun, M.T., Pirbhai, A., Ueda, K., Katori, N. & Selva, D. (2013) Sebaceous carcinoma in Japanese patients: clinical presentation, staging and outcomes. The British Journal of Ophthalmology, 97, 1459-1463.