Associations of polygenic risk for attention-deficit/hyperactivity disorder with general and specific dimensions of childhood psychological problems and facets of impulsivity.

Adolescent Attention Deficit Disorder with Hyperactivity / diagnosis Child Executive Function Humans Impulsive Behavior Multifactorial Inheritance Prospective Studies
Attention-deficit/hyperactivity disorder Executive functioning Impulsivity Mediation Polygenic risk scores

Journal

Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331

Informations de publication

Date de publication:
08 2022
Historique:
received: 18 02 2022
revised: 07 06 2022
accepted: 10 06 2022
pubmed: 26 6 2022
medline: 27 7 2022
entrez: 25 6 2022
Statut: ppublish

Résumé

A polygenic risk score (PRS) for attention-deficit/hyperactivity disorder (ADHD) has been found to be associated with ADHD in multiple studies, but also with many other dimensions of problems. Little is known, however, about the processes underlying these transdiagnostic associations. Using data from the baseline and 1-year follow-up assessments of 9- to 10-year-old children in the Adolescent Brain Cognitive Development™ (ABCD©) Study, associations were assessed between an ADHD PRS and both general and specific factors of psychological problems defined in bifactor modeling. Additionally, prospective mediated paths were tested from the ADHD PRS to dimensions of problems in the follow-up assessment through baseline measures of executive functioning (EF) and two facets of impulsivity: lower perseverance and greater impulsiveness in the presence of surgent positive emotions. Previous findings of modest but significant direct associations of the ADHD PRS with the general factor of psychological problems were replicated in both assessments in 4,483 children of European ancestry. In addition, significant statistical mediation was found from the ADHD PRS to the general factor, specific ADHD, and conduct problems in the follow-up assessment through each of the two facets of impulsivity. In contrast, EF did not statistically mediate associations between the ADHD PRS and psychological problems. These results suggest that polygenic risk transdiagnostically influences both psychological problems and facets of impulsivity, perhaps partly through indirect pathways via facets of impulsivity.

Identifiants

DOI: 10.1016/j.jpsychires.2022.06.019 PMID: 35752070 PMC: PMC10001434
pubmed: 35752070
pii: S0022-3956(22)00324-7
doi: 10.1016/j.jpsychires.2022.06.019
pmc: PMC10001434
mid: NIHMS1875569
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

187-193

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR000430
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA051039
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041120
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA051018
Pays : United States
Organisme : NIDA NIH HHS
ID : U24 DA041123
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA051038
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA051037
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA051016
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041106
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041117
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041148
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH098098
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041174
Pays : United States
Organisme : NIDA NIH HHS
ID : U24 DA041147
Pays : United States
Organisme : NIDA NIH HHS
ID : UG3 DA045251
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041093
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117014
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041134
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041022
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041156
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA050987
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041025
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA050989
Pays : United States
Organisme : NIMH NIH HHS
ID : R00 MH117274
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041089
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA050988
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041028
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041048
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

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Auteurs

Benjamin B Lahey (BB)

Department of Public Health Sciences, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA. Electronic address: blahey@uchicago.edu.

Lin Tong (L)

Department of Public Health Sciences, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA.

Brandon Pierce (B)

Department of Public Health Sciences, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA.

Donald Hedeker (D)

Department of Public Health Sciences, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA.

Marc G Berman (MG)

Department of Psychology, University of Chicago, 5848 S University Ave, Chicago, IL, 60637, USA. Electronic address: bermanm@uchicago.edu.

Carlos Cardenas-Iniguez (C)

Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, Los Angeles, CA, 90033, USA.

Tyler M Moore (TM)

Department of Psychiatry, University of Pennsylvania School of Medicine, 3700 Hamilton Walk, Philadelphia, PA, 19104, USA. Electronic address: tymoore@pennmedicine.upenn.edu.

Brooks Applegate (B)

Department of Educational Leadership, Research & Technology, Western Michigan University, 1903 West Michigan Avenue, Kalamazoo, MI, 49008, USA. Electronic address: brooks.applegate@wmich.edu.

Henning Tiemeier (H)

Chan School of Public Health, Harvard University, 677 Huntington Avenue, Boston, MA, 02215, USA. Electronic address: tiemeier@hsph.harvard.edu.

Antonia N Kaczkurkin (AN)

Department of Psychology, Vanderbilt University, 2301 Vanderbilt Place, Nashville, TN, 37240-7817, USA. Electronic address: Antonia.Kazckurkin@vanderbilt.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Associations of polygenic risk for...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles déficitaires de l'attention et du comportement perturbateur › Trouble déficitaire de l'attention avec hyperactivité › Associations of polygenic risk for...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Associations of polygenic risk for...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Fonction exécutive › Associations of polygenic risk for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Associations of polygenic risk for...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement impulsif › Associations of polygenic risk for...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité multifactorielle › Associations of polygenic risk for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Associations of polygenic risk for...