Neutrophil Extracellular Traps, Sepsis and COVID-19 - A Tripod Stand.
acute respiratory distress syndrome
cytokine storm
cytokines
homeostasis
inflammation
lymphocyte
pneumonia
septic shock
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
03
2022
accepted:
11
05
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
29
6
2022
Statut:
epublish
Résumé
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Majority of COVID-19 patients have mild disease but about 20% of COVID-19 patients progress to severe disease. These patients end up in the intensive care unit (ICU) with clinical manifestations of acute respiratory distress syndrome (ARDS) and sepsis. The formation of neutrophil extracellular traps (NETs) has also been associated with severe COVID-19. Understanding of the immunopathology of COVID-19 is critical for the development of effective therapeutics. In this article, we discuss evidence indicating that severe COVID-19 has clinical presentations consistent with the definitions of viral sepsis. We highlight the role of neutrophils and NETs formation in the pathogenesis of severe COVID-19. Finally, we highlight the potential of therapies inhibiting NETs formation for the treatment of COVID-19.
Identifiants
pubmed: 35757734
doi: 10.3389/fimmu.2022.902206
pmc: PMC9226304
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
902206Informations de copyright
Copyright © 2022 Ventura-Santana, Ninan, Snyder and Okeke.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Lancet. 2021 May 01;397(10285):1637-1645
pubmed: 33933206
EBioMedicine. 2020 Aug;58:102925
pubmed: 32745993
Front Immunol. 2018 Mar 16;9:516
pubmed: 29616030
Nat Rev Immunol. 2006 Mar;6(3):173-82
pubmed: 16498448
Science. 2018 Sep 28;361(6409):
pubmed: 30262472
Crit Care. 2012 Jul 26;16(4):R137
pubmed: 22835277
J Clin Invest. 2020 May 1;130(5):2620-2629
pubmed: 32217835
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Crit Care. 2012 Aug 13;16(4):R151
pubmed: 22889177
Cell. 2021 Feb 18;184(4):861-880
pubmed: 33497610
N Engl J Med. 2015 Jul 30;373(5):415-27
pubmed: 26172429
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
Best Pract Res Clin Rheumatol. 2021 Mar;35(1):101661
pubmed: 33526325
Lancet. 2020 May 9;395(10235):1517-1520
pubmed: 32311318
PLoS Pathog. 2009 Oct;5(10):e1000639
pubmed: 19876394
Clin Chim Acta. 2020 Oct;509:91-94
pubmed: 32511972
Nat Med. 2010 Aug;16(8):887-96
pubmed: 20676107
Pulm Pharmacol Ther. 2011 Oct;24(5):549-54
pubmed: 21540122
Front Immunol. 2020 Aug 18;11:2063
pubmed: 33013872
Blood. 2020 Sep 3;136(10):1169-1179
pubmed: 32597954
Metabolites. 2021 Oct 13;11(10):
pubmed: 34677415
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6748-53
pubmed: 19346483
Chest. 2010 Sep;138(3):559-67
pubmed: 20507948
J Innate Immun. 2016;8(2):156-70
pubmed: 26771196
J Innate Immun. 2018;10(1):3-13
pubmed: 28988241
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9813-8
pubmed: 20439745
Cell Host Microbe. 2012 Jul 19;12(1):109-16
pubmed: 22817992
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
Sci Immunol. 2018 Dec 7;3(30):
pubmed: 30530726
Sci Immunol. 2018 Aug 24;3(26):
pubmed: 30143555
Cell Microbiol. 2006 Apr;8(4):668-76
pubmed: 16548892
Blood. 2017 Mar 9;129(10):1357-1367
pubmed: 28073784
Shock. 2015 Aug;44(2):166-72
pubmed: 26009820
Mol Med. 2011 Mar-Apr;17(3-4):293-307
pubmed: 21046059
J Exp Med. 2020 Dec 7;217(12):
pubmed: 32926097
PLoS One. 2021 Apr 6;16(4):e0249570
pubmed: 33822821
PLoS One. 2011;6(12):e28526
pubmed: 22174830
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Eur Respir Rev. 2020 Jul 21;29(157):
pubmed: 32699026
J Thromb Haemost. 2014 Dec;12(12):2074-88
pubmed: 25163512
PLoS One. 2012;7(2):e32366
pubmed: 22389696
J Cell Biol. 2010 Nov 1;191(3):677-91
pubmed: 20974816
Curr Biol. 2006 Feb 21;16(4):396-400
pubmed: 16488874
Nat Rev Microbiol. 2021 Mar;19(3):155-170
pubmed: 33116300
J Am Coll Cardiol. 2020 Oct 20;76(16):1815-1826
pubmed: 32860872
J Exp Med. 2018 May 7;215(5):1287-1299
pubmed: 29622565
J Thromb Haemost. 2012 Jan;10(1):136-44
pubmed: 22044575
Science. 2020 Oct 23;370(6515):
pubmed: 32972995
J Antimicrob Chemother. 2021 Jan 1;76(1):30-42
pubmed: 33031488
Sci Transl Med. 2016 Oct 19;8(361):361ra138
pubmed: 27798263
Cochrane Database Syst Rev. 2021 Oct 18;10:CD015045
pubmed: 34658014
Crit Care. 2021 Feb 23;25(1):79
pubmed: 33622349
PLoS One. 2016 May 18;11(5):e0155685
pubmed: 27191593
Nat Rev Immunol. 2020 Oct;20(10):581-582
pubmed: 32839569
Biochem Soc Trans. 2022 Feb 28;50(1):21-32
pubmed: 35191493
N Engl J Med. 2020 Dec 3;383(23):2255-2273
pubmed: 33264547
Nat Rev Immunol. 2020 Sep;20(9):529-536
pubmed: 32728222
J Cell Biol. 2012 Sep 3;198(5):773-83
pubmed: 22945932
PLoS One. 2020 Oct 20;15(10):e0240012
pubmed: 33079950
Sci Rep. 2018 Feb 1;8(1):2068
pubmed: 29391442
J Exp Med. 2020 Dec 7;217(12):
pubmed: 32926098
Cell Death Differ. 2009 Nov;16(11):1438-44
pubmed: 19609275
Sci Immunol. 2021 Feb 23;6(56):
pubmed: 33622974
Cells. 2020 Oct 29;9(11):
pubmed: 33138195
Front Pharmacol. 2020 Jun 05;11:870
pubmed: 32581816
Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1977-84
pubmed: 25012129
J Med Virol. 2021 Jan;93(1):250-256
pubmed: 32592501
J Thromb Thrombolysis. 2021 Feb;51(2):446-453
pubmed: 33151461
Front Immunol. 2017 Jan 13;7:671
pubmed: 28133459
Sci Transl Med. 2013 Mar 27;5(178):178ra40
pubmed: 23536012
Nat Commun. 2018 Jul 27;9(1):2958
pubmed: 30054480
Front Cell Infect Microbiol. 2021 Oct 21;11:751232
pubmed: 34746027
Biomaterials. 2020 Apr;238:119836
pubmed: 32045782
Science. 2004 Mar 5;303(5663):1532-5
pubmed: 15001782
Mol Cell Proteomics. 2021;20:100113
pubmed: 34139362
Nature. 2000 Aug 17;406(6797):782-7
pubmed: 10963608
J Med Virol. 2008 Oct;80(10):1843-9
pubmed: 18712820
Front Cell Infect Microbiol. 2021 Sep 10;11:694186
pubmed: 34568088
Nat Cell Biol. 2009 May;11(5):521-6
pubmed: 19404331
J Clin Invest. 2020 Nov 2;130(11):6151-6157
pubmed: 32759504
BMJ. 2021 Jul 22;374:n1873
pubmed: 34301632
Annu Rev Immunol. 2011;29:399-413
pubmed: 21219176
Inflammation. 2004 Aug;28(4):237-44
pubmed: 15673166
Nat Med. 2015 Jul;21(7):815-9
pubmed: 26076037
Arthritis Res Ther. 2014 Jun 13;16(3):R122
pubmed: 24928093
Nature. 2014 Jan 30;505(7485):691-5
pubmed: 24284630
Nat Rev Immunol. 2020 Jul;20(7):448
pubmed: 32488203
J Virol. 2021 May 24;95(12):
pubmed: 33789998
Semin Immunopathol. 2017 Jul;39(5):517-528
pubmed: 28555385
Respir Res. 2017 Dec 12;18(1):207
pubmed: 29233147
BMJ. 2020 Mar 26;368:m1091
pubmed: 32217556
Lancet Rheumatol. 2020 Jul;2(7):e393-e400
pubmed: 32835245
Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5598-603
pubmed: 15034168
J Intensive Care. 2014 Dec 31;2(1):67
pubmed: 25705423
Crit Care Med. 2011 Aug;39(8):1886-95
pubmed: 21516036
Nat Cell Biol. 2017 Sep;19(9):1061-1070
pubmed: 28759028
JAMA. 2021 Jan 12;325(2):123-124
pubmed: 33331845
Clin Vaccine Immunol. 2013 Mar;20(3):319-27
pubmed: 23283640
Tuberc Respir Dis (Seoul). 2016 Apr;79(2):53-7
pubmed: 27066082
Nat Med. 2007 Apr;13(4):463-9
pubmed: 17384648
Cell Death Differ. 2021 Nov;28(11):3125-3139
pubmed: 34031543
Biochimie. 2008 Feb;90(2):227-42
pubmed: 18021746
Nat Microbiol. 2020 Apr;5(4):536-544
pubmed: 32123347
Acta Biomed. 2020 Mar 19;91(1):157-160
pubmed: 32191675
J Med Chem. 2020 Nov 25;63(22):13258-13265
pubmed: 32692176
Front Immunol. 2020 May 01;11:827
pubmed: 32425950
J Allergy Clin Immunol. 2011 May;127(5):1243-52.e7
pubmed: 21376380
Sci Transl Med. 2020 Nov 18;12(570):
pubmed: 33139519
Biomolecules. 2021 May 06;11(5):
pubmed: 34066385
Cells. 2021 Sep 26;10(10):
pubmed: 34685525
Crit Care Nurs Clin North Am. 2003 Mar;15(1):13-25
pubmed: 12597036
Eur Respir J. 2020 Dec 24;56(6):
pubmed: 32943404
Ann Rheum Dis. 2014 Oct;73(10):1854-63
pubmed: 23873874
Eur Respir J. 2021 Oct 14;58(4):
pubmed: 34649972
J Clin Invest. 2013 Jul;123(7):2981-93
pubmed: 23722903
Nat Chem Biol. 2011 Feb;7(2):75-7
pubmed: 21170021
JAMA Cardiol. 2020 Dec 29;:
pubmed: 33372956
Biochem Biophys Res Commun. 2020 Jan 29;522(1):33-39
pubmed: 31735330
Transl Res. 2017 May;183:87-103
pubmed: 28027930
JCI Insight. 2020 Jun 4;5(11):
pubmed: 32329756
Sci Rep. 2020 Nov 12;10(1):19630
pubmed: 33184506
Lancet. 2011 Apr 9;377(9773):1264-75
pubmed: 21435708
EBioMedicine. 2020 May;55:102763
pubmed: 32361250
Cell Discov. 2020 May 4;6:31
pubmed: 32377375
J Cell Biol. 2007 Jan 15;176(2):231-41
pubmed: 17210947
Sci Immunol. 2021 Jul 1;6(61):
pubmed: 34210785
Int Immunopharmacol. 2021 Nov;100:108137
pubmed: 34536744
Nat Med. 2009 Nov;15(11):1318-21
pubmed: 19855397
Kidney Int Rep. 2020 Nov;5(11):2079-2083
pubmed: 32839744
J Infect Dis. 2019 Aug 30;220(7):1166-1171
pubmed: 31115456
J Immunol. 2012 Sep 15;189(6):2689-95
pubmed: 22956760
Blood. 2011 Aug 18;118(7):1952-61
pubmed: 21673343
J Exp Med. 2020 Jun 1;217(6):
pubmed: 32302401
PLoS One. 2016 Feb 05;11(2):e0148142
pubmed: 26849138
Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15880-5
pubmed: 20798043
Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):988-994
pubmed: 33267662
Crit Care. 2013 Sep 12;17(5):R202
pubmed: 24028771
Science. 2020 Aug 7;369(6504):718-724
pubmed: 32661059
Cell Host Microbe. 2014 May 14;15(5):526-36
pubmed: 24832448
Front Immunol. 2020 Jul 10;11:1648
pubmed: 32754159
Respirol Case Rep. 2021 Dec 27;10(1):e0894
pubmed: 34992785
Semin Thromb Hemost. 2019 Feb;45(1):86-93
pubmed: 30634198
Front Immunol. 2018 Sep 27;9:2147
pubmed: 30319615