Immune Deviation in the Decidua During Term and Preterm Labor.
Th cells
Treg cells
decidua
macrophage
preterm labor
term labor
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
02
2022
accepted:
28
04
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
29
6
2022
Statut:
epublish
Résumé
The maternal-fetal immune disorder is considered to be an important factor of preterm birth (PTB); however, the underlying mechanism is still not fully understood. This study was designed to explore the innate and adaptive immune features in the decidua during term and preterm labor. Women delivered at term or preterm were classified into four groups: term not in labor (TNL, N=19), term in labor (TL, N=17), preterm not in labor (PNL, N=10), and preterm in labor (PIL, N=10). Decidua basalis and parietalis were collected and analyzed for macrophage subtypes (M1 and M2) as well as T helper 1 (Th1), Th2, Th17 and regulatory T (Treg) cells by flow cytometry and immunohistochemistry. Our results demonstrated significantly decreased frequencies of M2 cells and elevated M1/M2 ratio in the PIL group compared to that in the PNL group in both decidua basalis and parietalis, whereas no significant differences were found between the above two groups in both sites in terms of the polarization status of Th cells. On the contrary, macrophage subsets were comparable in the TL and TNL groups, whereas elevated Th1 percentages and Th1/Th2 ratio were observed in TL women compared to that in TNL women in the decidua. Interestingly, although the frequencies and ratios of Th17 and Treg were comparable among the four groups, the Th17/Treg ratios of these groups were significantly increased in decidua basalis than that in decidua parietalis. Collectively, the M1/M2 imbalance is associated with the breakdown of maternal-fetal immune tolerance during PTB, whereas the aberrant Th1/Th2 profile plays an important role in immune disorder during term labor. Moreover, Th17/Treg deviation is more remarkable in decidua basalis than in decidua parietalis.
Identifiants
pubmed: 35757768
doi: 10.3389/fimmu.2022.877314
pmc: PMC9226582
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
877314Informations de copyright
Copyright © 2022 Zha, Liu, Lin, Yu, Gao, Li, Wu, Gong, Bian, Kang, Zhi, Dang, Wang, Feng, Qiao, Huang and Zeng.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Hum Reprod. 2019 Jan 01;34(1):25-36
pubmed: 30500923
Immunology. 2011 Nov;134(3):281-91
pubmed: 21977998
Eur J Obstet Gynecol Reprod Biol. 2005 Oct 1;122(2):136-43
pubmed: 15893871
J Clin Med. 2021 Jan 18;10(2):
pubmed: 33477602
Lancet. 2017 Dec 17;388(10063):3027-3035
pubmed: 27839855
Obstet Gynecol. 2010 Aug;116(2 Pt 1):393-401
pubmed: 20664401
Trends Immunol. 2018 Apr;39(4):302-314
pubmed: 29433961
Front Immunol. 2018 May 09;9:993
pubmed: 29867970
Sci Immunol. 2017 Sep 1;2(15):
pubmed: 28864494
Front Immunol. 2021 Feb 25;12:642392
pubmed: 33717198
Cytokine. 2021 Dec;148:155707
pubmed: 34560611
Elife. 2019 Dec 12;8:
pubmed: 31829938
Eur Heart J. 2020 Mar 7;41(10):1067-1068
pubmed: 32144428
Immunity. 2018 Sep 18;49(3):397-412
pubmed: 30231982
Nat Immunol. 2004 Mar;5(3):266-71
pubmed: 14758358
Front Immunol. 2020 Mar 20;11:386
pubmed: 32265904
J Immunol. 2016 Mar 15;196(6):2476-2491
pubmed: 26889045
Am J Obstet Gynecol. 2011 Sep;205(3):235.e15-24
pubmed: 21763637
Nature. 2018 Nov;563(7731):347-353
pubmed: 30429548
J Reprod Immunol. 2009 Jun;80(1-2):122-31
pubmed: 19406481
Reprod Sci. 2010 Mar;17(3):209-18
pubmed: 20065301
PLoS One. 2016 Jun 22;11(6):e0155191
pubmed: 27333071
Science. 2014 Aug 15;345(6198):760-5
pubmed: 25124429
J Vis Exp. 2015 May 21;(99):e52863
pubmed: 26067211
Front Immunol. 2020 Jun 23;11:1182
pubmed: 32655556
J Reprod Immunol. 2020 Aug;140:103132
pubmed: 32380371
Front Immunol. 2021 May 12;12:672168
pubmed: 34054852
Nat Immunol. 2005 Apr;6(4):345-52
pubmed: 15785760
Lancet Glob Health. 2019 Jan;7(1):e37-e46
pubmed: 30389451
JCI Insight. 2021 Oct 8;6(19):
pubmed: 34622802
Am J Reprod Immunol. 2010 Jun;63(6):601-10
pubmed: 20455873
Lancet. 2021 Jun 26;397(10293):2497-2536
pubmed: 34043953
Am J Reprod Immunol. 2010 Feb;63(2):104-9
pubmed: 20015328
Front Immunol. 2019 Oct 18;10:2317
pubmed: 31681264
Hum Reprod Update. 2016 Sep;22(5):535-60
pubmed: 27363410
J Reprod Immunol. 2010 Jun;85(2):121-9
pubmed: 20439117
Nat Immunol. 2015 Apr;16(4):328-34
pubmed: 25789673
Front Immunol. 2021 Aug 17;12:724662
pubmed: 34484234
J Immunol. 2019 May 1;202(9):2585-2608
pubmed: 30918041
Am J Pathol. 2011 Aug;179(2):838-49
pubmed: 21801872
Am J Reprod Immunol. 2015 Aug;74(2):100-9
pubmed: 25582625
Placenta. 2006 Apr;27 Suppl A:S47-53
pubmed: 16442616
Front Immunol. 2019 Nov 27;10:2729
pubmed: 31827469
Nat Rev Immunol. 2017 Aug;17(8):469-482
pubmed: 28627518
Trends Mol Med. 2017 Jan;23(1):46-58
pubmed: 27914866
Inflammation. 2019 Dec;42(6):2119-2128
pubmed: 31468303
Genome Res. 2017 Mar;27(3):349-361
pubmed: 28174237
Lancet Glob Health. 2021 Sep;9(9):e1179-e1180
pubmed: 34416201
Int J Mol Sci. 2019 Oct 26;20(21):
pubmed: 31717776
Immunology. 1988 Apr;63(4):707-14
pubmed: 3284818
J Reprod Immunol. 2021 Apr;144:103268
pubmed: 33454392
Cell Rep. 2020 Jul 7;32(1):107874
pubmed: 32640239
Cell Mol Immunol. 2014 Nov;11(6):571-81
pubmed: 24954221
Ann N Y Acad Sci. 2011 Mar;1221:80-7
pubmed: 21401634
Hum Reprod. 2020 Nov 1;35(11):2454-2466
pubmed: 33107565
PLoS One. 2014 May 14;9(5):e96901
pubmed: 24828675
Sci Immunol. 2019 Jan 11;4(31):
pubmed: 30635356
Placenta. 2019 Apr;79:53-61
pubmed: 30929747
Am J Reprod Immunol. 2016 Dec;76(6):454-464
pubmed: 27767237
Placenta. 2020 Nov;101:221-229
pubmed: 33022545
J Reprod Immunol. 2021 Nov;148:103366
pubmed: 34492568
J Reprod Immunol. 2003 Oct;60(1):1-11
pubmed: 14568673
Mediators Inflamm. 2012;2012:967629
pubmed: 22719180