Carotid body responses to O
carbon monoxide
carbonic anhydrase
heme oxygenase
hydrogen sulfide
hypercapnia
hypercapnic ventilatory response
hypoxia
hypoxic ventilatory response
Journal
Acta physiologica (Oxford, England)
ISSN: 1748-1716
Titre abrégé: Acta Physiol (Oxf)
Pays: England
ID NLM: 101262545
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
09
06
2022
received:
07
03
2022
accepted:
10
06
2022
pubmed:
28
6
2022
medline:
13
10
2022
entrez:
27
6
2022
Statut:
ppublish
Résumé
Naked mole rats (NMRs) exhibit blunted hypoxic (HVR) and hypercapnic ventilatory responses (HCVR). The mechanism(s) underlying these responses are largely unknown. We hypothesized that attenuated carotid body (CB) sensitivity to hypoxia and hypercapnia contributes to the near absence of ventilatory responses to hypoxia and CO We measured ex vivo CB sensory nerve activity, phrenic nerve activity (an estimation of ventilation), and blood gases in urethane-anesthetized NMRs and C57BL/6 mice breathing normoxic, hypoxic, or hypercapnic gases. CB morphology, carbon monoxide, and H Relative to mice, NMRs had blunted CB and HVR. Morphologically, NMRs have larger CBs, which contained more glomus cells than in mice. Furthermore, NMR glomus cells form a dispersed pattern compared to a clustered pattern in mice. Hemeoxygenase (HO)-1 mRNA was elevated in NMR CBs, and an HO inhibitor increased CB sensitivity to hypoxia in NMRs. This increase was blocked by an H Consistent with our hypothesis, impaired CB responses to hypoxia contribute in part to the blunted HVR in NMRs. Conversely, the HCVR and CB are more sensitive to CO
Identifiants
pubmed: 35757963
doi: 10.1111/apha.13851
pmc: PMC9787741
doi:
Substances chimiques
RNA, Messenger
0
Carbon Dioxide
142M471B3J
Urethane
3IN71E75Z5
Carbon Monoxide
7U1EE4V452
Carbonic Anhydrases
EC 4.2.1.1
Oxygen
S88TT14065
Types de publication
Editorial
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13851Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL144454
Pays : United States
Informations de copyright
© 2022 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society.
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