Variants in Bedaquiline-Candidate-Resistance Genes: Prevalence in Bedaquiline-Naive Patients, Effect on MIC, and Association with Mycobacterium tuberculosis Lineage.
antibiotic resistance
antimicrobial resistance
bedaquiline
drug-resistant tuberculosis
epidemiology
phenotypic drug susceptibility testing
phylogeny
tuberculosis
whole-genome sequencing
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
19 07 2022
19 07 2022
Historique:
pubmed:
28
6
2022
medline:
22
7
2022
entrez:
27
6
2022
Statut:
ppublish
Résumé
Studies have shown that variants in bedaquiline-resistance genes can occur in isolates from bedaquiline-naive patients. We assessed the prevalence of variants in all bedaquiline-candidate-resistance genes in bedaquiline-naive patients, investigated the association between these variants and lineage, and the effect on phenotype. We used whole-genome sequencing to identify variants in bedaquiline-resistance genes in isolates from 509 bedaquiline treatment naive South African tuberculosis patients. A phylogenetic tree was constructed to investigate the association with the isolate lineage background. Bedaquiline MIC was determined using the UKMYC6 microtiter assay. Variants were identified in 502 of 509 isolates (98.6%), with the highest (85%) prevalence of variants in the
Identifiants
pubmed: 35758754
doi: 10.1128/aac.00322-22
pmc: PMC9295546
doi:
Substances chimiques
Antitubercular Agents
0
Diarylquinolines
0
bedaquiline
78846I289Y
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0032222Subventions
Organisme : NIAID NIH HHS
ID : R21 AI135756
Pays : United States
Références
BMC Genomics. 2019 Mar 29;20(1):252
pubmed: 30922221
Nat Commun. 2020 Jun 9;11(1):2917
pubmed: 32518235
Hum Mutat. 2016 Jun;37(6):564-9
pubmed: 26931183
Eur Respir J. 2015 Feb;45(2):554-7
pubmed: 25359333
Genome Med. 2020 Nov 25;12(1):104
pubmed: 33239092
BMC Microbiol. 2021 May 28;21(1):157
pubmed: 34044775
J Antimicrob Chemother. 2017 Jul 1;72(7):1901-1906
pubmed: 28387862
N Engl J Med. 2018 Aug 30;379(9):823-833
pubmed: 30157391
Nucleic Acids Res. 2012 Dec;40(22):11189-201
pubmed: 23066108
Antimicrob Agents Chemother. 2012 Jun;56(6):3047-53
pubmed: 22470121
N Engl J Med. 2015 Nov 12;373(20):1986-8
pubmed: 26559594
Microb Genom. 2021 Nov;7(11):
pubmed: 34793294
J Clin Microbiol. 2020 Oct 21;58(11):
pubmed: 32907992
Antimicrob Agents Chemother. 2017 May 24;61(6):
pubmed: 28320727
PLoS One. 2014 Jul 10;9(7):e102135
pubmed: 25010492
Eur Respir J. 2022 May 12;:
pubmed: 35301246
Antimicrob Agents Chemother. 2019 Feb 26;63(3):
pubmed: 30602521
Tuberculosis (Edinb). 2017 Dec;107:13-19
pubmed: 29050760
J Antimicrob Chemother. 2017 Mar 1;72(3):684-690
pubmed: 28031270
Antimicrob Agents Chemother. 2014 May;58(5):2979-81
pubmed: 24590481
Nucleic Acids Res. 2021 Jul 2;49(W1):W293-W296
pubmed: 33885785
Nat Genet. 2011 May;43(5):491-8
pubmed: 21478889
J Infect. 2020 May;80(5):527-535
pubmed: 31981638
N Engl J Med. 2019 May 30;380(22):2178-2180
pubmed: 31141643
Antimicrob Agents Chemother. 2019 Jul 25;63(8):
pubmed: 31138569
BMC Genomics. 2020 Jan 28;21(1):80
pubmed: 31992201
Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0116421
pubmed: 34460306
J Clin Microbiol. 2006 Jan;44(1):254-6
pubmed: 16390984
Mol Biol Evol. 2020 May 1;37(5):1530-1534
pubmed: 32011700
Lancet Infect Dis. 2022 Apr;22(4):496-506
pubmed: 34780706
Lancet Microbe. 2021 Nov;2(11):e604-e616
pubmed: 34796339
Antimicrob Agents Chemother. 2018 Aug 27;62(9):
pubmed: 29941636
Nat Genet. 2010 Jun;42(6):498-503
pubmed: 20495566
J Antimicrob Chemother. 2020 Aug 1;75(8):2031-2043
pubmed: 32361756
Genome Med. 2019 Jun 24;11(1):41
pubmed: 31234910
Antimicrob Agents Chemother. 2016 Jul 22;60(8):4590-9
pubmed: 27185800
Lancet Respir Med. 2018 Sep;6(9):699-706
pubmed: 30001994
Nat Methods. 2017 Jun;14(6):587-589
pubmed: 28481363