Western-Style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies.

Carcinogenesis Class I Phosphatidylinositol 3-Kinases Colorectal Neoplasms / epidemiology Diet, Western Escherichia coli / genetics Escherichia coli Infections Humans Prospective Studies Proto-Oncogene Proteins B-raf / genetics Proto-Oncogene Proteins p21(ras)
Immunology Microbiome Molecular Pathological Epidemiology

Journal

Gastroenterology
ISSN: 1528-0012
Titre abrégé: Gastroenterology
Pays: United States
ID NLM: 0374630

Informations de publication

Date de publication:
10 2022
Historique:
received: 31 12 2021
revised: 20 05 2022
accepted: 15 06 2022
pubmed: 28 6 2022
medline: 28 9 2022
entrez: 27 6 2022
Statut: ppublish

Résumé

Evidence supports a carcinogenic role of Escherichia coli carrying the pks island that encodes enzymes for colibactin biosynthesis. We hypothesized that the association of the Western-style diet (rich in red and processed meat) with colorectal cancer incidence might be stronger for tumors containing higher amounts of pks Western diet score was calculated using food frequency questionnaire data obtained every 4 years during follow-up of 134,775 participants in 2 United States-wide prospective cohort studies. Using quantitative polymerase chain reaction, we measured pks The association of the Western diet score with colorectal cancer incidence was stronger for tumors containing higher levels of pks The Western-style diet is associated with a higher incidence of colorectal cancer containing abundant pks

Sections du résumé

BACKGROUND & AIMS
Evidence supports a carcinogenic role of Escherichia coli carrying the pks island that encodes enzymes for colibactin biosynthesis. We hypothesized that the association of the Western-style diet (rich in red and processed meat) with colorectal cancer incidence might be stronger for tumors containing higher amounts of pks
METHODS
Western diet score was calculated using food frequency questionnaire data obtained every 4 years during follow-up of 134,775 participants in 2 United States-wide prospective cohort studies. Using quantitative polymerase chain reaction, we measured pks
RESULTS
The association of the Western diet score with colorectal cancer incidence was stronger for tumors containing higher levels of pks
CONCLUSIONS
The Western-style diet is associated with a higher incidence of colorectal cancer containing abundant pks

Identifiants

DOI: 10.1053/j.gastro.2022.06.054 PMID: 35760086 PMC: PMC9509428
pubmed: 35760086
pii: S0016-5085(22)00672-2
doi: 10.1053/j.gastro.2022.06.054
pmc: PMC9509428
mid: NIHMS1818864
pii:
doi:

Substances chimiques

Class I Phosphatidylinositol 3-Kinases EC 2.7.1.137
Proto-Oncogene Proteins B-raf EC 2.7.11.1
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

862-874

Subventions

Organisme : NCI NIH HHS
ID : R35 CA197735
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA118553
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK043351
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA167552
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA137178
Pays : United States
Organisme : NIDDK NIH HHS
ID : K24 DK098311
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA169141
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA253185
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA127003
Pays : United States
Organisme : NCI NIH HHS
ID : K07 CA190673
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA055075
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA151993
Pays : United States
Organisme : NCI NIH HHS
ID : K07 CA188126
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA167552
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 AGA Institute. Published by Elsevier Inc. All rights reserved.

Références

Arch Intern Med. 2003 Feb 10;163(3):309-14
pubmed: 12578511
Cancer Cell. 2018 Jun 11;33(6):954-964
pubmed: 29657127
Nat Commun. 2021 Feb 12;12(1):1003
pubmed: 33579932
JAMA Oncol. 2017 Jul 01;3(7):921-927
pubmed: 28125762
Front Oncol. 2022 Feb 11;12:841552
pubmed: 35223525
Gut. 2011 Mar;60(3):397-411
pubmed: 21036793
Am J Clin Nutr. 2000 Oct;72(4):912-21
pubmed: 11010931
Nat Rev Clin Oncol. 2021 Apr;18(4):230-243
pubmed: 33219329
PLoS One. 2008;3(11):e3698
pubmed: 19002263
Ann Surg Oncol. 2015 Apr;22(4):1226-1235
pubmed: 25326395
Oncoimmunology. 2019 Sep 19;8(12):e1664275
pubmed: 31741761
Science. 2019 Feb 15;363(6428):
pubmed: 30765538
Cell Host Microbe. 2019 Jun 12;25(6):789-802.e5
pubmed: 31194939
Ann Oncol. 2019 Apr 1;30(4):510-519
pubmed: 30721924
Front Oncol. 2020 Dec 09;10:607909
pubmed: 33363037
Gut. 2019 Aug;68(8):1417-1429
pubmed: 30782617
Annu Rev Pathol. 2019 Jan 24;14:83-103
pubmed: 30125150
Semin Cancer Biol. 2018 Oct;52(Pt 1):1-8
pubmed: 29425888
Nat Med. 2019 Apr;25(4):667-678
pubmed: 30936548
J Mol Diagn. 2006 May;8(2):209-17
pubmed: 16645207
Gut. 2012 Jun;61(6):794-7
pubmed: 22490520
Trends Cancer. 2020 Apr;6(4):277-287
pubmed: 32209443
Am J Clin Nutr. 2019 Sep 1;110(3):701-712
pubmed: 31291462
JAMA Oncol. 2015 Aug;1(5):653-61
pubmed: 26181352
Curr Dev Nutr. 2017 Nov 01;1(11):
pubmed: 29595830
Nature. 2020 Apr;580(7802):269-273
pubmed: 32106218
Mol Cancer. 2014 May 31;13:135
pubmed: 24885062
Nutrients. 2019 Dec 23;12(1):
pubmed: 31877961
Stat Med. 2016 Feb 28;35(5):782-800
pubmed: 26619806
Am J Epidemiol. 2021 Jun 1;190(6):1122-1132
pubmed: 33350436
Nat Protoc. 2008;3(6):1101-8
pubmed: 18546601
Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):
pubmed: 33408252
Gut. 2012 Jun;61(6):847-54
pubmed: 22427238
Science. 2019 Sep 6;365(6457):
pubmed: 31395743
N Engl J Med. 2013 Sep 19;369(12):1095-105
pubmed: 24047059
Trends Microbiol. 2020 May;28(5):401-423
pubmed: 32298617
Am J Epidemiol. 2018 May 1;187(5):1051-1063
pubmed: 29036411
Mol Cell. 2019 Apr 18;74(2):227-229
pubmed: 31002804
Int J Cancer. 2020 Jun 1;146(11):3147-3159
pubmed: 32037530
Eur J Cancer Prev. 2012 Jan;21(1):15-23
pubmed: 21946864
Br J Nutr. 2020 Nov 14;124(9):931-942
pubmed: 32475373
Nat Rev Gastroenterol Hepatol. 2020 Jun;17(6):317-318
pubmed: 32317778
Nat Commun. 2015 Apr 28;6:6342
pubmed: 25919227
J Mol Diagn. 2005 Aug;7(3):413-21
pubmed: 16049314
Hum Genet. 2021 May;140(5):725-746
pubmed: 33180176
Science. 2018 Feb 2;359(6375):592-597
pubmed: 29420293
N Engl J Med. 2012 Oct 25;367(17):1596-606
pubmed: 23094721
Am J Epidemiol. 1992 May 15;135(10):1114-26; discussion 1127-36
pubmed: 1632423
J Mol Diagn. 2010 Mar;12(2):177-83
pubmed: 20093385
Nat Med. 2019 Jun;25(6):968-976
pubmed: 31171880
J Am Diet Assoc. 1993 Jul;93(7):790-6
pubmed: 8320406
Cancer Res. 2018 Oct 1;78(19):5538-5547
pubmed: 30275053
Nat Med. 2020 Jul;26(7):1063-1069
pubmed: 32483361
Eur J Epidemiol. 2018 Apr;33(4):381-392
pubmed: 29264788
Science. 2012 Oct 5;338(6103):120-3
pubmed: 22903521
J Pathol. 2019 Apr;247(5):615-628
pubmed: 30632609
Science. 2006 Aug 11;313(5788):848-51
pubmed: 16902142
Nat Med. 2009 Sep;15(9):1016-22
pubmed: 19701202

Auteurs

Kota Arima (K)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

Rong Zhong (R)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Tomotaka Ugai (T)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Melissa Zhao (M)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Koichiro Haruki (K)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

Naohiko Akimoto (N)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Mai Chan Lau (MC)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Kazuo Okadome (K)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Raaj S Mehta (RS)

Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

Juha P Väyrynen (JP)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts; Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

Junko Kishikawa (J)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Tyler S Twombly (TS)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Shanshan Shi (S)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Kenji Fujiyoshi (K)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Keisuke Kosumi (K)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Yoko Ogata (Y)

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Hideo Baba (H)

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Fenglei Wang (F)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Kana Wu (K)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Mingyang Song (M)

Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Xuehong Zhang (X)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Charles S Fuchs (CS)

Yale Cancer Center, New Haven, Connecticut; Department of Medicine, Yale School of Medicine, New Haven, Connecticut; Smilow Cancer Hospital, New Haven, Connecticut; Genentech, South San Francisco, California.

Cynthia L Sears (CL)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Walter C Willett (WC)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Edward L Giovannucci (EL)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Jeffrey A Meyerhardt (JA)

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

Wendy S Garrett (WS)

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

Curtis Huttenhower (C)

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Andrew T Chan (AT)

Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Jonathan A Nowak (JA)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Marios Giannakis (M)

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Shuji Ogino (S)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Cancer Immunology and Cancer Epidemiology Programs, Dana-Farber Harvard Cancer Center, Boston, Massachusetts. Electronic address: sogino@bwh.harvard.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Western-Style Diet, pks Island-Carrying...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Phosphatidylinositol-4-phosphate 3-kinase › Phosphatidylinositol 3-kinases de classe I › Western-Style Diet, pks Island-Carrying...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Western-Style Diet, pks Island-Carrying...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Régime occidental › Western-Style Diet, pks Island-Carrying...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Western-Style Diet, pks Island-Carrying...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Infections à Escherichia coli › Western-Style Diet, pks Island-Carrying...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Western-Style Diet, pks Island-Carrying...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Western-Style Diet, pks Island-Carrying...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Kinases raf › Protéines proto-oncogènes B-raf › Western-Style Diet, pks Island-Carrying...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › Western-Style Diet, pks Island-Carrying...