Effect of race on cardiometabolic responses to once-weekly exenatide: insights from the Exenatide Study of Cardiovascular Event Lowering (EXSCEL).
Cardiovascular risk factors
Exenatide once weekly
Racial differences
Journal
Cardiovascular diabetology
ISSN: 1475-2840
Titre abrégé: Cardiovasc Diabetol
Pays: England
ID NLM: 101147637
Informations de publication
Date de publication:
27 06 2022
27 06 2022
Historique:
received:
10
03
2022
accepted:
14
06
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
30
6
2022
Statut:
epublish
Résumé
To determine whether there were racial differences in short-term cardiometabolic responses to once-weekly exenatide (EQW) in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL). EXSCEL enrolled 14,752 patients with type 2 diabetes (hemoglobin A Mean 6-month placebo-adjusted HbA Short-term cardiometabolic responses to EQW were similar in the main racial groups in EXSCEL, apart from a greater pulse rate increase in Asians. https://clinicaltrials.gov NCT01144338.
Sections du résumé
BACKGROUND
To determine whether there were racial differences in short-term cardiometabolic responses to once-weekly exenatide (EQW) in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL).
METHODS
EXSCEL enrolled 14,752 patients with type 2 diabetes (hemoglobin A
RESULTS
Mean 6-month placebo-adjusted HbA
CONCLUSIONS
Short-term cardiometabolic responses to EQW were similar in the main racial groups in EXSCEL, apart from a greater pulse rate increase in Asians.
TRIAL REGISTRATION
https://clinicaltrials.gov NCT01144338.
Identifiants
pubmed: 35761271
doi: 10.1186/s12933-022-01555-z
pii: 10.1186/s12933-022-01555-z
pmc: PMC9238154
doi:
Substances chimiques
Blood Glucose
0
Glycated Hemoglobin A
0
Hypoglycemic Agents
0
Venoms
0
Exenatide
9P1872D4OL
Banques de données
ClinicalTrials.gov
['NCT01144338']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
116Informations de copyright
© 2022. The Author(s).
Références
Diabetes Care. 2021 May;44(5):1236-1241
pubmed: 33707305
BMJ. 2012 Mar 15;344:e1454
pubmed: 22422870
Mol Metab. 2021 Apr;46:101102
pubmed: 33068776
Postgrad Med. 2020 May;132(4):358-367
pubmed: 32164466
JAMA Netw Open. 2019 Mar 1;2(3):e191471
pubmed: 30924888
Diabetes Metab J. 2019 Aug;43(4):410-421
pubmed: 30604598
Diabetes Obes Metab. 2017 Dec;19(12):1793-1797
pubmed: 28573708
Heart. 2022 Feb;108(4):251-257
pubmed: 33985989
Nature. 2019 Oct;574(7778):372-377
pubmed: 31619789
Diabetes Care. 2020 Feb;43(2):487-493
pubmed: 31857443
Circ Res. 1986 Aug;59(2):178-93
pubmed: 2874900
J Clin Invest. 2002 Jul;110(1):43-52
pubmed: 12093887
Diabetes Care. 2020 Aug;43(8):1948-1957
pubmed: 33534728
Eur J Endocrinol. 2019 Dec;181(6):R211-R234
pubmed: 31600725
Diabetes Res Clin Pract. 2016 Apr;114:160-72
pubmed: 26827116
Diabetes Obes Metab. 2018 Jun;20(6):1427-1434
pubmed: 29405540
Ann Med. 2000 Jul;32(5):341-9
pubmed: 10949066
Curr Hypertens Rep. 2016 Feb;18(2):16
pubmed: 26803771
Am Heart J. 2016 Apr;174:103-10
pubmed: 26995376
Diabetes Care. 2018 Dec;41(12):2669-2701
pubmed: 30291106
Curr Diabetes Rev. 2021;17(9):e122820189511
pubmed: 33371853
J Magn Reson Imaging. 2020 Jun;51(6):1679-1688
pubmed: 31799782
Int J Clin Pract. 2012 Nov;66(11):1021-32
pubmed: 22925173
Cell Metab. 2016 Jul 12;24(1):15-30
pubmed: 27345422
Circulation. 2015 Nov 10;132(19):1795-804
pubmed: 26311724
Cardiovasc Res. 2011 Jan 1;89(1):72-8
pubmed: 20736238
Diabetes Obes Metab. 2014 Oct;16(10):900-9
pubmed: 24655583
Clin Auton Res. 2008 Apr;18(2):90-5
pubmed: 18414771
Cochrane Database Syst Rev. 2016 Sep 06;9:MR000007
pubmed: 27595791
Br J Nutr. 2008 Apr;99(4):840-5
pubmed: 17903341
Lancet. 2008 Oct 4;372(9645):1240-50
pubmed: 18782641
N Engl J Med. 2017 Sep 28;377(13):1228-1239
pubmed: 28910237
Diabetol Metab Syndr. 2017 Jan 18;9:6
pubmed: 28115994
Postgrad Med. 2012 Jul;124(4):21-32
pubmed: 22913891
Am Heart J. 2017 May;187:1-9
pubmed: 28454792