Ergosterol isolated from cloud ear mushroom (Auricularia polytricha) attenuates bisphenol A-induced BV2 microglial cell inflammation.

Agaricales / metabolism Anti-Inflammatory Agents / metabolism Auricularia Benzhydryl Compounds Ergosterol / metabolism Inflammation / metabolism Microglia / metabolism NF-kappa B / metabolism Phenols Reactive Oxygen Species / metabolism
Auricularia polytricha Bisphenol A Ergosterol Neuroinflammation

Journal

Food research international (Ottawa, Ont.)
ISSN: 1873-7145
Titre abrégé: Food Res Int
Pays: Canada
ID NLM: 9210143

Informations de publication

Date de publication:
07 2022
Historique:
received: 16 03 2022
revised: 20 05 2022
accepted: 25 05 2022
entrez: 28 6 2022
pubmed: 29 6 2022
medline: 30 6 2022
Statut: ppublish

Résumé

Bisphenol A (BPA) has been reported to have neurotoxic properties that may increase the risk of neurodegenerative diseases by inducing neuroinflammation. Auricularia polytricha (AP) is an edible mushroom with several medicinal properties. Herein, the anti-neuroinflammatory effects of AP extracts against BPA-induced inflammation of BV2 microglial cells were investigated. Hexane (APH) and ethanol (APE) extracts of AP inhibited BPA-induced neuroinflammation in BV2 microglia by reducing microglial activation and the expression of pro-inflammatory cytokines. These anti-inflammatory effects were regulated by the NF-κB signaling pathway. In addition, APH and APE exhibited antioxidative effects by increasing the activity of the SOD-1 enzyme and restoring the accumulation of reactive oxygen species (ROS) in BPA-induced BV2 cells. Moreover, the conditioned medium prepared using BPA-induced BV2 cells demonstrated that the presence of APH or APE could attenuate ROS production in HT-22 cells. Further, ergosterol was isolated from APE and also showed anti-inflammatory and antioxidative activities. In conclusion, AP extracts and ergosterol attenuated neuroinflammation against BPA induction in BV2 microglial cells through the NF-κB signaling pathway.

Identifiants

DOI: 10.1016/j.foodres.2022.111433 PMID: 35761673
pubmed: 35761673
pii: S0963-9969(22)00490-2
doi: 10.1016/j.foodres.2022.111433
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Benzhydryl Compounds 0
NF-kappa B 0
Phenols 0
Reactive Oxygen Species 0
bisphenol A MLT3645I99
Ergosterol Z30RAY509F

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111433

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Chanin Sillapachaiyaporn (C)

Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand; Laboratory of Signal Transduction, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.

Siriporn Chuchawankul (S)

Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand; Immunomodulation of Natural Products Research Group, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Sunita Nilkhet (S)

Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Nuntanat Moungkote (N)

Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Tewarit Sarachana (T)

Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand; SYstems Neuroscience of Autism and PSychiatric Disorders (SYNAPS) Research Unit, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Alison T Ung (AT)

Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand; Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand; School of Mathematical and Physical Sciences, Faculty of Science, The University of Technology Sydney, Sydney, NSW 2007, Australia.

Seung Joon Baek (SJ)

Laboratory of Signal Transduction, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. Electronic address: baeksj@snu.ac.kr.

Tewin Tencomnao (T)

Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand; Natural Products for Neuroprotection and Anti-ageing (Neur-Age Natura) Research Unit, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: tewin.t@chula.ac.th.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Champignons › Basidiomycota › Agaricales › Ergosterol isolated from cloud ear mushroom...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Ergosterol isolated from cloud ear mushroom...
questionsmedicales.fr › Eucaryotes › Champignons › Basidiomycota › Auricularia (genre) › Ergosterol isolated from cloud ear mushroom...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzhydryliques › Ergosterol isolated from cloud ear mushroom...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Cholestanes › Cholestènes › Ergostérol › Ergosterol isolated from cloud ear mushroom...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Ergosterol isolated from cloud ear mushroom...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Ergosterol isolated from cloud ear mushroom...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Ergosterol isolated from cloud ear mushroom...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Ergosterol isolated from cloud ear mushroom...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Ergosterol isolated from cloud ear mushroom...