Inhibitory framing in hypersexual patients with Parkinson's disease. An fMRI pilot study.
Addiction
Dopamine
Functional MRI
Impulse control
Journal
Experimental brain research
ISSN: 1432-1106
Titre abrégé: Exp Brain Res
Pays: Germany
ID NLM: 0043312
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
28
03
2022
accepted:
07
06
2022
pubmed:
29
6
2022
medline:
20
7
2022
entrez:
28
6
2022
Statut:
ppublish
Résumé
Hypersexuality in medicated patients with PD is caused by an increased influence of motivational drive areas and a decreased influence of inhibitory control areas due to dopaminergic medication. In this pilot study, we test a newly developed paradigm investigating the influence of dopaminergic medication on brain activation elicited by sexual pictures with and without inhibitory contextual framing. Twenty PD patients with and without hypersexuality were examined with fMRI either OFF or ON standardized dopaminergic medication. The paradigm consisted of a priming phase where either a neutral context or an inhibitory context was presented. This priming phase was either followed by a sexual or a neutral target. Sexual, compared to neutral pictures resulted in a BOLD activation of various brain regions implicated in sexual processing. Hypersexual PD patients showed increased activity compared to PD controls in these regions. There was no relevant effect of medication between the two groups. The inhibitory context elicited less activation in inhibition-related areas in hypersexual PD, but had no influence on the perception of sexual cues. The paradigm partially worked: reactivity of motivational brain areas to sexual cues was increased in hypersexual PD and inhibitory contextual framing lead to decreased activation of inhibitory control areas in PD. We could not find a medication effect and the length of the inhibitory stimulus was not optimal to suppress reactivity to sexual cues. Our data provide new insights into the mechanisms of hypersexuality and warrant a replication with a greater cohort and an optimized stimulus length in the future.
Identifiants
pubmed: 35763033
doi: 10.1007/s00221-022-06397-5
pii: 10.1007/s00221-022-06397-5
pmc: PMC9288360
doi:
Substances chimiques
Dopamine Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2097-2107Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 249777455
Organisme : Deutsche Forschungsgemeinschaft
ID : 431549029
Informations de copyright
© 2022. The Author(s).
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