Histopathology of autoimmune bullous dermatoses: what's new?

Autoantibodies Autoimmune Diseases Diagnosis, Differential Humans Skin / pathology Skin Diseases, Vesiculobullous / diagnosis
Acantholysis Autoimmune bullous Dermatitis herpetiformis Direct immunofluorescence Immunobullous Linear IgA bullous dermatosis Pemphigoid Pemphigus

Journal

Human pathology
ISSN: 1532-8392
Titre abrégé: Hum Pathol
Pays: United States
ID NLM: 9421547

Informations de publication

Date de publication:
10 2022
Historique:
received: 14 04 2022
revised: 19 06 2022
accepted: 21 06 2022
pubmed: 29 6 2022
medline: 4 10 2022
entrez: 28 6 2022
Statut: ppublish

Résumé

Autoimmune bullous dermatoses are characterized by the presence of tissue-bound and often circulating pathogenic autoantibodies targeting structural components of the skin and/or mucous membranes. The diagnostic workup for this heterogeneous group of disorders consists of a multi-step process, of which the light microscopic examination is a crucial component. This review is organized following a classification scheme that is based on two main histopathologic features, namely level of intraepithelial split and composition of the inflammatory infiltrate. Overall, we aim to place emphasis on the histopathologic clues that can assist pathologists in differential diagnosis and review the updates in the literature.

Identifiants

DOI: 10.1016/j.humpath.2022.06.021 PMID: 35764145
pubmed: 35764145
pii: S0046-8177(22)00166-6
doi: 10.1016/j.humpath.2022.06.021
pii:
doi:

Substances chimiques

Autoantibodies 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

69-89

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Burak Tekin (B)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.

Emma F Johnson (EF)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA.

Carilyn N Wieland (CN)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA.

Lawrence E Gibson (LE)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA.

Michael J Camilleri (MJ)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA.

Amer N Kalaaji (AN)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA.

Nneka I Comfere (NI)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA.

Margot S Peters (MS)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA.

Julia S Lehman (JS)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA. Electronic address: lehman.julia@mayo.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Histopathology of autoimmune bullous...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Histopathology of autoimmune bullous...
questionsmedicales.fr › Diagnostic › Diagnostic différentiel › Histopathology of autoimmune bullous...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Histopathology of autoimmune bullous...
questionsmedicales.fr › Système tégumentaire › Peau › Histopathology of autoimmune bullous...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses vésiculobulleuses › Histopathology of autoimmune bullous...