Beneficial Effects of the Direct AMP-Kinase Activator PXL770 in In Vitro and In Vivo Models of X-Linked Adrenoleukodystrophy.

AMP-Activated Protein Kinases / metabolism ATP Binding Cassette Transporter, Subfamily D, Member 1 / genetics ATP-Binding Cassette Transporters / genetics Adenosine Monophosphate Adenylate Kinase / metabolism Adrenoleukodystrophy / drug therapy Animals Fatty Acids / metabolism Mice Pyridones / pharmacology Tetrahydronaphthalenes / pharmacology

Journal

The Journal of pharmacology and experimental therapeutics
ISSN: 1521-0103
Titre abrégé: J Pharmacol Exp Ther
Pays: United States
ID NLM: 0376362

Informations de publication

Date de publication:
08 2022
Historique:
received: 14 03 2022
accepted: 09 05 2022
pubmed: 29 6 2022
medline: 3 8 2022
entrez: 28 6 2022
Statut: ppublish

Résumé

X-linked adrenoleukodystrophy (ALD) is a severe orphan disease caused by mutations in the peroxisomal

Identifiants

DOI: 10.1124/jpet.122.001208 PMID: 35764327
pubmed: 35764327
pii: jpet.122.001208
doi: 10.1124/jpet.122.001208
doi:

Substances chimiques

2-chloro-3-(1-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-6-oxo-5-phenyl-7H-thieno)(2,3-b)pyridin-4-olate potassium 0
ATP Binding Cassette Transporter, Subfamily D, Member 1 0
ATP-Binding Cassette Transporters 0
Abcd1 protein, mouse 0
Fatty Acids 0
Pyridones 0
Tetrahydronaphthalenes 0
Adenosine Monophosphate 415SHH325A
AMP-Activated Protein Kinases EC 2.7.11.31
Adenylate Kinase EC 2.7.4.3

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

208-222

Informations de copyright

Copyright © 2022 by The Author(s).

Auteurs

Pierre-Axel Monternier (PA)

Poxel SA, Lyon, France (P.-A.M., P.T., P.G.D., P.F., S.B., D.E.M., S.H.-B.) and Departments of Neurology (P.P., N.K., J.S.) and Neurosurgery (T.N.N.), Henry Ford Health System, Detroit, Michigan.

Parveen Parasar (P)

Poxel SA, Lyon, France (P.-A.M., P.T., P.G.D., P.F., S.B., D.E.M., S.H.-B.) and Departments of Neurology (P.P., N.K., J.S.) and Neurosurgery (T.N.N.), Henry Ford Health System, Detroit, Michigan.

Pierre Theurey (P)

Poxel SA, Lyon, France (P.-A.M., P.T., P.G.D., P.F., S.B., D.E.M., S.H.-B.) and Departments of Neurology (P.P., N.K., J.S.) and Neurosurgery (T.N.N.), Henry Ford Health System, Detroit, Michigan pierre.theurey@poxelpharma.com.

Pascale Gluais Dagorn (P)

Poxel SA, Lyon, France (P.-A.M., P.T., P.G.D., P.F., S.B., D.E.M., S.H.-B.) and Departments of Neurology (P.P., N.K., J.S.) and Neurosurgery (T.N.N.), Henry Ford Health System, Detroit, Michigan.

Navtej Kaur (N)

Poxel SA, Lyon, France (P.-A.M., P.T., P.G.D., P.F., S.B., D.E.M., S.H.-B.) and Departments of Neurology (P.P., N.K., J.S.) and Neurosurgery (T.N.N.), Henry Ford Health System, Detroit, Michigan.

Tavarekere N Nagaraja (TN)

Poxel SA, Lyon, France (P.-A.M., P.T., P.G.D., P.F., S.B., D.E.M., S.H.-B.) and Departments of Neurology (P.P., N.K., J.S.) and Neurosurgery (T.N.N.), Henry Ford Health System, Detroit, Michigan.

Pascale Fouqueray (P)

Poxel SA, Lyon, France (P.-A.M., P.T., P.G.D., P.F., S.B., D.E.M., S.H.-B.) and Departments of Neurology (P.P., N.K., J.S.) and Neurosurgery (T.N.N.), Henry Ford Health System, Detroit, Michigan.

Sébastien Bolze (S)

Poxel SA, Lyon, France (P.-A.M., P.T., P.G.D., P.F., S.B., D.E.M., S.H.-B.) and Departments of Neurology (P.P., N.K., J.S.) and Neurosurgery (T.N.N.), Henry Ford Health System, Detroit, Michigan.

David E Moller (DE)

Poxel SA, Lyon, France (P.-A.M., P.T., P.G.D., P.F., S.B., D.E.M., S.H.-B.) and Departments of Neurology (P.P., N.K., J.S.) and Neurosurgery (T.N.N.), Henry Ford Health System, Detroit, Michigan.

Jaspreet Singh (J)

Poxel SA, Lyon, France (P.-A.M., P.T., P.G.D., P.F., S.B., D.E.M., S.H.-B.) and Departments of Neurology (P.P., N.K., J.S.) and Neurosurgery (T.N.N.), Henry Ford Health System, Detroit, Michigan.

Sophie Hallakou-Bozec (S)

Poxel SA, Lyon, France (P.-A.M., P.T., P.G.D., P.F., S.B., D.E.M., S.H.-B.) and Departments of Neurology (P.P., N.K., J.S.) and Neurosurgery (T.N.N.), Henry Ford Health System, Detroit, Michigan.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › AMP-Activated Protein Kinases › Beneficial Effects of the Direct AMP-Kinase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs ABC › Sous-famille D de transporteurs à cassette liant l'ATP › Membre-1 de la sous-famille D de transporteurs à cassette liant l'ATP › Beneficial Effects of the Direct AMP-Kinase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs ABC › Beneficial Effects of the Direct AMP-Kinase...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › AMP › Beneficial Effects of the Direct AMP-Kinase...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Phosphate Group Acceptor) › Adenylate kinase › Beneficial Effects of the Direct AMP-Kinase...
questionsmedicales.fr › Maladies endocriniennes › Maladies des surrénales › Insuffisance surrénale › Adrénoleucodystrophie › Beneficial Effects of the Direct AMP-Kinase...
questionsmedicales.fr › Eucaryotes › Animaux › Beneficial Effects of the Direct AMP-Kinase...
questionsmedicales.fr › Lipides › Acides gras › Beneficial Effects of the Direct AMP-Kinase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Beneficial Effects of the Direct AMP-Kinase...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Pyridones › Beneficial Effects of the Direct AMP-Kinase...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › 1,2,3,4-Tétrahydro-naphtalènes › Beneficial Effects of the Direct AMP-Kinase...