The Myeloid-Specific Transcription Factor PU.1 Upregulates Mannose Receptor Expression but Represses Basal Activity of the HIV-LTR Promoter.
HIV-1
PU.1 transcription factor
Tat
mannose receptor
transcriptional repression
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
27 07 2022
27 07 2022
Historique:
pubmed:
30
6
2022
medline:
30
7
2022
entrez:
29
6
2022
Statut:
ppublish
Résumé
Human mannose receptor 1 (MRC1) is a cell surface receptor expressed in macrophages and other myeloid cells that inhibits human immunodeficiency virus type 1 (HIV-1) particle release by tethering virions to producer cell membranes. HIV-1 counteracts MRC1 expression by inhibiting
Identifiants
pubmed: 35766490
doi: 10.1128/jvi.00652-22
pmc: PMC9327697
doi:
Substances chimiques
Mannose Receptor
0
proto-oncogene protein Spi-1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0065222Subventions
Organisme : NCI NIH HHS
ID : 75N91019D00024
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 AI000669
Pays : United States
Organisme : HHS | National Institutes of Health (NIH)
ID : 1 Z01 AI000669
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