E2 ubiquitin-conjugating enzymes (UBCs): drivers of ubiquitin signalling in plants.
Ubiquitin
plant biology
ubiquitin ligases
ubiquitin signalling
ubiquitin-conjugating enzymes
ubiquitin-like proteins
Journal
Essays in biochemistry
ISSN: 1744-1358
Titre abrégé: Essays Biochem
Pays: England
ID NLM: 0043306
Informations de publication
Date de publication:
05 08 2022
05 08 2022
Historique:
received:
16
03
2022
revised:
10
06
2022
accepted:
13
06
2022
pubmed:
30
6
2022
medline:
9
8
2022
entrez:
29
6
2022
Statut:
ppublish
Résumé
Most research in the field of ubiquitination has focused on E3 ubiquitin ligases because they are the specificity determinants of the ubiquitination process. Nevertheless, E2s are responsible for the catalysis during ubiquitin transfer, and are therefore, at the heart of the ubiquitination process. Arabidopsis has 37 ubiquitin E2s with additional ones mediating the attachment of ubiquitin-like proteins (e.g. SUMO, Nedd8 and ATG8). Importantly, E2s largely determine the type of ubiquitin chain built, and therefore, the type of signal that decides over the fate of the modified protein, such as degradation by the proteasome (Lys48-linked ubiquitin chains) or relocalization (Lys63-linked ubiquitin chains). Moreover, new regulatory layers impinging on E2s activity, including post-translational modifications or cofactors, are emerging that highlight the importance of E2s.
Identifiants
pubmed: 35766526
pii: 231513
doi: 10.1042/EBC20210093
doi:
Substances chimiques
Ubiquitin
0
Ubiquitins
0
Ubiquitin-Conjugating Enzymes
EC 2.3.2.23
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-110Informations de copyright
© 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.