Intracellular connections between basal bodies promote the coordinated behavior of motile cilia.
Journal
Molecular biology of the cell
ISSN: 1939-4586
Titre abrégé: Mol Biol Cell
Pays: United States
ID NLM: 9201390
Informations de publication
Date de publication:
15 09 2022
15 09 2022
Historique:
pubmed:
30
6
2022
medline:
11
9
2022
entrez:
29
6
2022
Statut:
ppublish
Résumé
Hydrodynamic flow produced by multiciliated cells is critical for fluid circulation and cell motility. Hundreds of cilia beat with metachronal synchrony for fluid flow. Cilia-driven fluid flow produces extracellular hydrodynamic forces that cause neighboring cilia to beat in a synchronized manner. However, hydrodynamic coupling between neighboring cilia is not the sole mechanism that drives cilia synchrony. Cilia are nucleated by basal bodies (BBs) that link to each other and to the cell's cortex via BB-associated appendages. The intracellular BB and cortical network is hypothesized to synchronize ciliary beating by transmitting cilia coordination cues. The extent of intracellular ciliary connections and the nature of these stimuli remain unclear. Moreover, how BB connections influence the dynamics of individual cilia has not been established. We show by focused ion beam scanning electron microscopy imaging that cilia are coupled both longitudinally and laterally in the ciliate
Identifiants
pubmed: 35767367
doi: 10.1091/mbc.E22-05-0150
pmc: PMC9582806
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
br18Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM099820
Pays : United States
Organisme : NHLBI NIH HHS
ID : F31 HL147495
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103432
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM140813
Pays : United States
Organisme : NCI NIH HHS
ID : 75N91019D00024
Pays : United States
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