Genomic surveillance of SARS-CoV-2 in patients presenting neurological manifestations.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
03
2022
accepted:
02
06
2022
entrez:
30
6
2022
pubmed:
1
7
2022
medline:
6
7
2022
Statut:
epublish
Résumé
During the first wave of infections, neurological symptoms in Coronavirus Disease 2019 (COVID-19) patients raised particular concern, suggesting that, in a subset of patients, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could invade and damage cells of the central nervous system (CNS). Indeed, up to date several in vitro and in vivo studies have shown the ability of SARS-CoV-2 to reach the CNS. Both viral and/or host related features could explain why this occurs only in certain individuals and not in all the infected population. The aim of the present study was to evaluate if onset of neurological manifestations in COVID-19 patients was related to specific viral genomic signatures. To this end, viral genome was extracted directly from nasopharyngeal swabs of selected SARS-CoV-2 positive patients presenting a spectrum of neurological symptoms related to COVID-19, ranging from anosmia/ageusia to more severe symptoms. By adopting a whole genome sequences approach, here we describe a panel of known as well as unknown mutations detected in the analyzed SARS-CoV-2 genomes. While some of the found mutations were already associated with an improved viral fitness, no common signatures were detected when comparing viral sequences belonging to specific groups of patients. In conclusion, our data support the notion that COVID-19 neurological manifestations are mainly linked to patient-specific features more than to virus genomic peculiarities.
Identifiants
pubmed: 35771751
doi: 10.1371/journal.pone.0270024
pii: PONE-D-22-08037
pmc: PMC9246207
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0270024Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Front Neurol. 2021 Jan 20;11:573095
pubmed: 33551947
Front Cell Infect Microbiol. 2020 Oct 06;10:575613
pubmed: 33123498
Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2251-2261
pubmed: 32253535
Cell. 2020 Aug 20;182(4):812-827.e19
pubmed: 32697968
Am J Pathol. 2021 Dec;191(12):2064-2071
pubmed: 34506752
Gene Rep. 2022 Mar;26:101505
pubmed: 35071820
Neural Regen Res. 2022 Jun;17(6):1228-1239
pubmed: 34782556
Virus Res. 2020 Nov;289:198170
pubmed: 32979477
Neurocrit Care. 2021 Jun;34(3):1062-1071
pubmed: 32661794
CNS Neurosci Ther. 2020 May;26(5):499-501
pubmed: 32266761
Nat Rev Immunol. 2020 Jun;20(6):363-374
pubmed: 32346093
NPJ Parkinsons Dis. 2020 Aug 20;6:18
pubmed: 32885037
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30679-30686
pubmed: 33184173
Nat Commun. 2020 Nov 26;11(1):6013
pubmed: 33243994
Nature. 2021 Apr;592(7852):116-121
pubmed: 33106671
Pathogens. 2020 Apr 29;9(5):
pubmed: 32365466
Front Microbiol. 2022 Feb 23;13:829094
pubmed: 35283834
Brain. 2020 Oct 1;143(10):3104-3120
pubmed: 32637987
Front Microbiol. 2020 Jul 22;11:1800
pubmed: 32793182
Stem Cells Transl Med. 2021 Nov;10(11):1491-1499
pubmed: 34302450
Bioinformatics. 2014 Nov 15;30(22):3276-8
pubmed: 25095880
Trends Cardiovasc Med. 2022 Apr 21;:
pubmed: 35461991
Nat Commun. 2021 Jan 19;12(1):434
pubmed: 33469026
Ann Neurol. 2020 Aug;88(2):423-427
pubmed: 32418288
Viruses. 2019 Dec 20;12(1):
pubmed: 31861926
Nat Rev Genet. 2021 Dec;22(12):757-773
pubmed: 34535792
Neurology. 2020 Sep 8;95(10):445-449
pubmed: 32586897
Int Immunopharmacol. 2022 Apr;105:108565
pubmed: 35123183
mBio. 2022 Apr 26;13(2):e0313521
pubmed: 35229638
Trends Immunol. 2020 Dec;41(12):1100-1115
pubmed: 33132005
Pathogens. 2020 Mar 04;9(3):
pubmed: 32143502
Curr Top Microbiol Immunol. 2005;287:57-94
pubmed: 15609509
Nature. 2021 Jul;595(7869):707-712
pubmed: 34098568
Microbes Infect. 2020 Nov - Dec;22(10):598-607
pubmed: 33049387
Cells. 2020 May 20;9(5):
pubmed: 32443810
Nat Commun. 2020 Nov 25;11(1):5986
pubmed: 33239633
Ann Neurol. 2020 Oct;88(4):860-861
pubmed: 32715524
Lancet Neurol. 2020 Nov;19(11):919-929
pubmed: 33031735
Nat Rev Microbiol. 2006 Feb;4(2):121-32
pubmed: 16415928
Biology (Basel). 2021 Jan 26;10(2):
pubmed: 33530355
Can J Neurol Sci. 2021 Jan;48(1):66-76
pubmed: 32665054
Nat Microbiol. 2020 Apr;5(4):536-544
pubmed: 32123347
Mol Biol Evol. 2015 Jan;32(1):268-74
pubmed: 25371430
Brain Behav Immun. 2020 Jul;87:18-22
pubmed: 32240762
J Neuroimmune Pharmacol. 2020 Dec;15(4):574-577
pubmed: 32930936
Brief Bioinform. 2019 Jul 19;20(4):1160-1166
pubmed: 28968734
Cell Res. 2020 Oct;30(10):928-931
pubmed: 32753756
Sci Adv. 2020 Jul 31;6(31):
pubmed: 32937591
Lancet Neurol. 2020 Sep;19(9):767-783
pubmed: 32622375
F1000Res. 2022 Jan 5;11:5
pubmed: 35514606
Med Sci Monit. 2021 Jun 19;27:e932962
pubmed: 34145211
J Transl Med. 2020 Apr 22;18(1):179
pubmed: 32321524
JAMA Neurol. 2020 Jun 1;77(6):683-690
pubmed: 32275288
Nat Microbiol. 2020 Nov;5(11):1403-1407
pubmed: 32669681
Nat Commun. 2021 Feb 8;12(1):848
pubmed: 33558493