Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever.
Bacteria
Disease status
Human
MAIT cells
Polyfunctionality
Salmonella
Journal
Cellular immunology
ISSN: 1090-2163
Titre abrégé: Cell Immunol
Pays: Netherlands
ID NLM: 1246405
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
07
04
2022
revised:
15
06
2022
accepted:
16
06
2022
pubmed:
1
7
2022
medline:
10
8
2022
entrez:
30
6
2022
Statut:
ppublish
Résumé
We have previously demonstrated that Mucosal-Associated Invariant T (MAIT) cells secrete multiple cytokines after exposure to Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever in humans. However, whether cytokine secreting MAIT cells can enhance or attenuate the clinical severity of bacterial infections remain debatable. This study characterizes human MAIT cell functions in subjects participating in a wild-type S. Typhi human challenge model. Here, we found that MAIT cells exhibit distinct functional signatures associated with protection against typhoid fever. We also observed that the cytokine patterns of MAIT cell responses, rather than the average number of cytokines expressed, are more predictive of typhoid fever outcomes. These results might enable us to objectively, based on functional parameters, identify cytokine patterns that may serve as predictive biomarkers during natural infection and vaccination.
Identifiants
pubmed: 35772315
pii: S0008-8749(22)00097-1
doi: 10.1016/j.cellimm.2022.104572
pmc: PMC9377420
mid: NIHMS1822276
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104572Subventions
Organisme : NIAID NIH HHS
ID : U19 AI142725
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007524
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI082655
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109776
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI036525
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
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