Activation of adenosine A3 receptor attenuates progression of osteoarthritis through inhibiting the NLRP3/caspase-1/GSDMD induced signalling.

Animals Caspase 1 / metabolism Chondrocytes / metabolism Inflammasomes / metabolism NLR Family, Pyrin Domain-Containing 3 Protein / metabolism Osteoarthritis / drug therapy Pain / metabolism Phosphate-Binding Proteins Pore Forming Cytotoxic Proteins Rats Reactive Oxygen Species / metabolism Receptor, Adenosine A3 / metabolism
A3AR NLRP3 ROS osteoarthritis pain pyroptosis

Journal

Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777

Informations de publication

Date de publication:
08 2022
Historique:
revised: 26 05 2022
received: 07 12 2021
accepted: 01 06 2022
pubmed: 2 7 2022
medline: 4 8 2022
entrez: 1 7 2022
Statut: ppublish

Résumé

The specific adenosine A3 receptor (A3AR) agonist (CF101) has potential for inflammation and pain in various disease, such as arthritis, cancer and neuropathic pain, while the role of A3AR in post-traumatic OA and the underlying mechanism is largely unknown. CF101 was orally administrated in OA rats induced by anterior cruciate ligament transection (ACLT) surgery, and the rat primary chondrocytes were stimulated by hydrogen peroxide (H

Identifiants

DOI: 10.1111/jcmm.17438 PMID: 35775127 PMC: PMC9344816
pubmed: 35775127
doi: 10.1111/jcmm.17438
pmc: PMC9344816
doi:

Substances chimiques

Gsdmd protein, rat 0
Inflammasomes 0
NLR Family, Pyrin Domain-Containing 3 Protein 0
Nlrp3 protein, rat 0
Phosphate-Binding Proteins 0
Pore Forming Cytotoxic Proteins 0
Reactive Oxygen Species 0
Receptor, Adenosine A3 0
Caspase 1 EC 3.4.22.36

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4230-4243

Subventions

Organisme : 13th Five-Year Major Special Provincial Funding
ID : GX18B023
Organisme : The National Key R&D Program of China
ID : 2017YFD0502200

Informations de copyright

© 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

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Auteurs

Hui Bai (H)

Heilongjiang Key Laboratory for Animal Disease Pathogenesis and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
ORCID: 0000-0002-9013-7873

Zhiheng Zhang (Z)

Heilongjiang Key Laboratory for Animal Disease Pathogenesis and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
ORCID: 0000-0002-9838-4350

Lin Liu (L)

Heilongjiang Key Laboratory for Animal Disease Pathogenesis and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
ORCID: 0000-0002-6196-4845

Xinyu Wang (X)

Heilongjiang Key Laboratory for Animal Disease Pathogenesis and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
ORCID: 0000-0003-2151-9824

Xiaopeng Song (X)

Heilongjiang Key Laboratory for Animal Disease Pathogenesis and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
ORCID: 0000-0003-4881-3935

Li Gao (L)

Heilongjiang Key Laboratory for Animal Disease Pathogenesis and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
ORCID: 0000-0001-9190-0562

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Activation of adenosine A3 receptor attenuates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Caspases › Caspases initiatrices › Caspase-1 › Activation of adenosine A3 receptor attenuates...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Chondrocytes › Activation of adenosine A3 receptor attenuates...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Activation of adenosine A3 receptor attenuates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Protéines NLR › Protéine-3 de la famille des NLR contenant un domaine pyrine › Activation of adenosine A3 receptor attenuates...
questionsmedicales.fr › Maladies ostéomusculaires › Arthrose › Activation of adenosine A3 receptor attenuates...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › Activation of adenosine A3 receptor attenuates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison aux phosphates › Activation of adenosine A3 receptor attenuates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Activation of adenosine A3 receptor attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Activation of adenosine A3 receptor attenuates...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Activation of adenosine A3 receptor attenuates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P1 › Récepteur A3 à l'adénosine › Activation of adenosine A3 receptor attenuates...