VEGF and VEGFR family members are expressed by neoplastic cells of NF1-associated tumors and may play an oncogenic role in malignant peripheral nerve sheath tumor growth through an autocrine loop.
Humans
Carcinogenesis
Endothelial Cells
/ metabolism
Neovascularization, Pathologic
Nerve Sheath Neoplasms
/ pathology
Neurofibromatosis 1
/ pathology
Neurofibrosarcoma
Proto-Oncogene Proteins c-akt
Receptors, Vascular Endothelial Growth Factor
Vascular Endothelial Growth Factor A
/ metabolism
Autocrine Communication
Malignant peripheral nerve sheath tumor
Neurofibroma
Neurofibromatosis type 1
VEGF
VEGF-R
Journal
Annals of diagnostic pathology
ISSN: 1532-8198
Titre abrégé: Ann Diagn Pathol
Pays: United States
ID NLM: 9800503
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
14
06
2022
accepted:
17
06
2022
pubmed:
2
7
2022
medline:
19
10
2022
entrez:
1
7
2022
Statut:
ppublish
Résumé
Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder. The role of angiogenesis and VEGF pathway in the pathogenesis of neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs) remains poorly understood. We assessed the expression of VEGF and VEGFR family members in cohorts of plexiform neurofibromas (pNF), MPNSTs and MPNST cell lines at transcript [pNF, n = 49; MPNST, n = 34] and protein levels [pNF, n = 21; MPNST, n = 9]. VEGF and VEGFR members were variably expressed in cell lines. VEGFA (p = 3.10
Identifiants
pubmed: 35777330
pii: S1092-9134(22)00099-5
doi: 10.1016/j.anndiagpath.2022.151997
pii:
doi:
Substances chimiques
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Receptors, Vascular Endothelial Growth Factor
EC 2.7.10.1
Vascular Endothelial Growth Factor A
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
151997Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no conflict of interest to declare. This work was supported by Roche laboratory (Bourse de recherche mélanome et autres tumeurs cutanées (hors lymphomes)) [2013].