Effect of hydrophile-lipophile balance of the linker in Gal/GalNAc ligands on high-affinity binding of galactosylated liposomes by the asialoglycoprotein receptor.

Asialoglycoprotein Receptor / metabolism Galactose Hepatocytes / metabolism Ligands Liposomes / pharmacology
Asialoglycoprotein receptors Enzymatic catalysis Galactose ligands Hydrophile–lipophile balance Linkers Liposomes Molecular dynamics

Journal

International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127

Informations de publication

Date de publication:
25 Aug 2022
Historique:
received: 17 03 2022
revised: 24 06 2022
accepted: 24 06 2022
pubmed: 2 7 2022
medline: 17 8 2022
entrez: 1 7 2022
Statut: ppublish

Résumé

In this study, we explored the effect of the hydrophile-lipophile balance (HLB) in the linker unit of Galactose (Gal)/N-acetylgalactosamine (GalNAc) ligands on their affinity toward asialoglycoprotein receptors (ASGPRs). Two Gal/GalNAc ligands with lipophilic linkers-{(5-cholesten-3b-ol)[(2-acetamido-2-deoxy-d-galactopyranose-6-o)sebacate]} (CHS-6-GalNAc) and {(5-cholesten-3b-ol)[(d-galactopyranose-6-o)sebacate]} (CHS-6-Gal)-and two with hydrophilic linkers-{(5-cholesten-yl)[(4-O-b-D-galactopyranosyl)-D-glucitol-6-yl]sebacate} (CHS-1-Gal) and {(5-cholesten-3a-ol)[(2-acetamido-2-deoxy-d-galactopyranose-6-o)3,6-dioxa-octanedioate]} (CHS-PEG

Identifiants

DOI: 10.1016/j.ijpharm.2022.121967 PMID: 35777585
pubmed: 35777585
pii: S0378-5173(22)00522-1
doi: 10.1016/j.ijpharm.2022.121967
pii:
doi:

Substances chimiques

Asialoglycoprotein Receptor 0
Ligands 0
Liposomes 0
Galactose X2RN3Q8DNE

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

121967

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Hua Nie (H)

Jiaying University, Meizhou 514031, China; Institute of Hakka Medicinal Bio-resources, Medical College, Jiaying University, Meizhou 514031, China; Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of Characteristic Agricultural Resources in Mountainous Areas, JiaYing University, Meizhou, Guangdong 514015, China.

Xiao-Min Liu (XM)

Institute of Hakka Medicinal Bio-resources, Medical College, Jiaying University, Meizhou 514031, China.

Qi-Xuan Yang (QX)

Jiaying University, Meizhou 514031, China.

Xiao-Dong Luo (XD)

Jiaying University, Meizhou 514031, China.

Ying Zhao (Y)

Jiaying University, Meizhou 514031, China.

Sheng-Yuan Zhang (SY)

Jiaying University, Meizhou 514031, China; Institute of Hakka Medicinal Bio-resources, Medical College, Jiaying University, Meizhou 514031, China; Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of Characteristic Agricultural Resources in Mountainous Areas, JiaYing University, Meizhou, Guangdong 514015, China. Electronic address: niehua007@163.com.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs des asialoglycoprotéines › Effect of hydrophile-lipophile balance of the...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Galactose › Effect of hydrophile-lipophile balance of the...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Effect of hydrophile-lipophile balance of the...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Effect of hydrophile-lipophile balance of the...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › Effect of hydrophile-lipophile balance of the...