Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial.
Cardiac arrest
Driving pressure
Mechanical power
Mechanical ventilation
Outcome
Ventilator settings
Journal
Intensive care medicine
ISSN: 1432-1238
Titre abrégé: Intensive Care Med
Pays: United States
ID NLM: 7704851
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
12
03
2022
accepted:
24
05
2022
pubmed:
3
7
2022
medline:
26
7
2022
entrez:
2
7
2022
Statut:
ppublish
Résumé
The optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. The aim of this study was to describe the ventilatory settings applied in the first 72 h of mechanical ventilation in patients after out-of-hospital cardiac arrest and their association with 6-month outcomes. Preplanned sub-analysis of the Target Temperature Management-2 trial. Clinical outcomes were mortality and functional status (assessed by the Modified Rankin Scale) 6 months after randomization. A total of 1848 patients were included (mean age 64 [Standard Deviation, SD = 14] years). At 6 months, 950 (51%) patients were alive and 898 (49%) were dead. Median tidal volume (V Protective ventilation strategies are commonly applied in patients after cardiac arrest. Ventilator settings in the first 72 h after hospital admission, in particular driving pressure and respiratory rate, may influence 6-month outcomes.
Identifiants
pubmed: 35780195
doi: 10.1007/s00134-022-06756-4
pii: 10.1007/s00134-022-06756-4
pmc: PMC9304050
doi:
Banques de données
ClinicalTrials.gov
['NCT02908308']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1024-1038Investigateurs
Niklas Nielsen
(N)
Jan Bělohlávek
(J)
Clifton Callaway
(C)
Alain Cariou
(A)
Tobias Cronberg
(T)
Josef Dankiewicz
(J)
Glenn Eastwood
(G)
David Erlinge
(D)
Hans Friberg
(H)
Jan Hovdenes
(J)
Janus Christian Jakobsen
(JC)
Michael Joannidis
(M)
Hans Kirkegaard
(H)
Helena Levin
(H)
Gisela Lilja
(G)
Matt P G Morgan
(MPG)
Alistair D Nichol
(AD)
Per Nordberg
(P)
Mauro Oddo
(M)
Paolo Pelosi
(P)
Christian Rylander
(C)
Manoj Saxena
(M)
Christian Storm
(C)
Fabio S Taccone
(FS)
Susann Ullén
(S)
Matt P Wise
(MP)
Paul J Young
(PJ)
Kathy Rowan
(K)
David Harrison
(D)
Paul Mouncey
(P)
Manu Shankar-Hari
(M)
Duncan Young
(D)
Susann Ullén
(S)
Theis Lange
(T)
Karolina Palmér
(K)
Ulla-Britt Karlsson
(UB)
Simon Heissler
(S)
Frances Bass
(F)
Naomi Hammond
(N)
John Myburgh
(J)
Colman Taylor
(C)
Adele Bellino
(A)
Marwa Abel-All
(M)
Ben Finfer
(B)
Carolyn Koch
(C)
Yang Li
(Y)
Anne O'Connor
(A)
Julia Pilowsky
(J)
Tina Schneider
(T)
Anna Tippett
(A)
Bridget Ady
(B)
Tessa Broadley
(T)
Amanda Brown
(A)
Liz Melgaard
(L)
Mimi Morgan
(M)
Vanessa Singh
(V)
Rebecca Symons
(R)
Kathrin Becker
(K)
Nathalie Van Sante
(N)
Vendula Saleova
(V)
Silvie Zerzanova
(S)
Helena Levin
(H)
Samia Sefir-Kribel
(S)
Ute Lübeck
(U)
Mario Negri
(M)
Martina Carrara
(M)
Kathryn Fernando
(K)
Diane Mackle
(D)
Leanlove Navarra
(L)
Judith Riley
(J)
Elin Westerheim
(E)
Marianne Flatebø
(M)
Ameldina Ceric
(A)
Zana Haxhija
(Z)
Lovisa Terling
(L)
Lena Bossmar
(L)
Liz Jergle
(L)
Helén Holm Månsson
(HH)
Samia Abed Maillard
(SA)
Andreja Vujicic Zagar
(AV)
Christina Jodlauk
(C)
Helen Hill
(H)
Jennifer Scrivens
(J)
Kate Ainscough
(K)
Ciara Fahey
(C)
Rinaldo Bellomo
(R)
Leah Peck
(L)
Helen Young
(H)
Winston Cheung
(W)
Rosalba Cross
(R)
Michael Hayes
(M)
Nitin Jain
(N)
Mark Kol
(M)
Asim Shah
(A)
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(A)
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(H)
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(FE)
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Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2022. The Author(s).
Références
Kim Y-M, Yim H-W, Jeong S-H, Klem ML, Callaway CW (2012) Does therapeutic hypothermia benefit adult cardiac arrest patients presenting with non-shockable initial rhythms? A systematic review and meta-analysis of randomized and non-randomized studies. Resuscitation 83:188–196
pubmed: 21835145
Robba C, Siwicka-Gieroba D, Sikter A, Battaglini D, Dąbrowski W, Schultz MJ et al (2020) Pathophysiology and clinical consequences of arterial blood gases and pH after cardiac arrest. Intensive Care Med Exp 8:19
pubmed: 33336311
pmcid: 7746422
Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A et al (2016) Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315:788
pubmed: 26903337
Neto AS, Barbas CSV, Simonis FD, Artigas-Raventós A, Canet J, Determann RM et al (2016) Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study. Lancet Respir Med 4:882–893
pubmed: 27717861
Sutherasan Y, Peñuelas O, Muriel A, Vargas M, Frutos-Vivar F, Brunetti I et al (2015) Management and outcome of mechanically ventilated patients after cardiac arrest. Crit Care 19:215
pubmed: 25953483
pmcid: 4457998
Harmon MBA, van Meenen DMP, van der Veen ALIP, Binnekade JM, Dankiewicz J, Ebner F et al (2018) Practice of mechanical ventilation in cardiac arrest patients and effects of targeted temperature management: a substudy of the targeted temperature management trial. Resuscitation 129:29–36
pubmed: 29763713
EL Costa V, Slutsky AS, Brochard LJ, Brower R, Serpa-Neto A, Cavalcanti AB et al (2021) Ventilatory variables and mechanical power in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 204:303–311
pubmed: 33784486
Robba C, Nielsen N, Dankiewicz J, Badenes R, Battaglini D, Ball L et al (2022) Ventilation management and outcomes in out-of-hospital cardiac arrest: a protocol for a preplanned secondary analysis of the TTM2 trial. BMJ Open 12:e058001
pubmed: 35241476
pmcid: 8896064
Dankiewicz J, Cronberg T, Lilja G, Jakobsen JC, Bělohlávek J, Callaway C et al (2019) Targeted hypothermia versus targeted Normothermia after out-of-hospital cardiac arrest (TTM2): a randomized clinical trial—rationale and design. Am Heart J 217:23–31
pubmed: 31473324
Dankiewicz J, Cronberg T, Lilja G, Jakobsen JC, Levin H, Ullén S et al (2021) Hypothermia versus normothermia after out-of-hospital cardiac arrest. N Engl J Med 384:2283–2294
pubmed: 34133859
von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP (2007) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370:1453–1457
Charlson M, Szatrowski TP, Peterson J, Gold J (1994) Validation of a combined comorbidity index. J Clin Epidemiol 47:1245–1251
pubmed: 7722560
Gattinoni L, Tonetti T, Cressoni M, Cadringher P, Herrmann P, Moerer O et al (2016) Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med 42:1567–1575
pubmed: 27620287
Sinha P, Calfee CS, Beitler JR, Soni N, Ho K, Matthay MA et al (2019) Physiologic analysis and clinical performance of the ventilatory ratio in acute respiratory distress syndrome. Am J Respir Crit Care Med 199:333–341
pubmed: 30211618
pmcid: 6363976
Royston P, Saurbrei W (2008) Multivariable model-building: a pragmatic approach to regression anaylsis based on fractional polynomials for modelling continuous variables.
Jann B (2020) Relative distribution analysis in Stata. Stata J [Internet] 21:885–951
Young PJ, Bailey M, Bellomo R, Bernard S, Bray J, Jakkula P et al (2020) Conservative or liberal oxygen therapy in adults after cardiac arrest. Resuscitation 157:15–22
pubmed: 33058991
Roberts BW, Kilgannon JH, Chansky ME, Mittal N, Wooden J, Trzeciak S (2013) Association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post–cardiac arrest syndrome. Circulation 127:2107–2113
pubmed: 23613256
Palmer E, Post B, Klapaukh R, Marra G, MacCallum NS, Brealey D et al (2019) The association between supraphysiologic arterial oxygen levels and mortality in critically ill patients. A multicenter observational cohort study. Am J Respir Crit Care Med 200:1373–1380
pubmed: 31513754
pmcid: 6884048
Pilcher J, Weatherall M, Shirtcliffe P, Bellomo R, Young P, Beasley R (2012) The effect of hyperoxia following cardiac arrest: a systematic review and meta-analysis of animal trials. Resuscitation 83:417–422
pubmed: 22226734
Roberts BW, Kilgannon J, Chansky ME, Trzeciak S (2014) Association between initial prescribed minute ventilation and post-resuscitation partial pressure of arterial carbon dioxide in patients with post-cardiac arrest syndrome. Ann Intensive Care 4:9
pubmed: 24602367
pmcid: 3973966
Tejerina E, Pelosi P, Muriel A, Peñuelas O, Sutherasan Y, Frutos-Vivar F et al (2017) Association between ventilatory settings and development of acute respiratory distress syndrome in mechanically ventilated patients due to brain injury. J Crit Care 38:341–345
pubmed: 27914908
Nolan JP, Sandroni C, Böttiger BW, Cariou A, Cronberg T, Friberg H et al (2021) European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care. Intensive Care Med 47:369–421
pubmed: 33765189
pmcid: 7993077
Lundbye JB, Rai M, Ramu B, Hosseini-Khalili A, Li D, Slim HB et al (2012) Therapeutic hypothermia is associated with improved neurologic outcome and survival in cardiac arrest survivors of non-shockable rhythms. Resuscitation 83:202–207
pubmed: 21864480
Nolan JP, Sandroni C, Böttiger BW, Cariou A, Cronberg T, Friberg H et al (2021) European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: post-resuscitation care. Resuscitation 161:220–269
pubmed: 33773827
Serpa Neto A, Deliberato RO, Johnson AEW, Bos LD, Amorim P, Pereira SM et al (2018) Mechanical power of ventilation is associated with mortality in critically ill patients: an analysis of patients in two observational cohorts. Intensive Care Med 44:1914–1922
pubmed: 30291378
Coppola S, Caccioppola A, Froio S, Formenti P, De Giorgis V, Galanti V et al (2020) Effect of mechanical power on intensive care mortality in ARDS patients. Crit Care 24:246
pubmed: 32448389
pmcid: 7245621
Bellani G, Grassi A, Sosio S, Gatti S, Kavanagh BP, Pesenti A et al (2019) Driving pressure is associated with outcome during assisted ventilation in acute respiratory distress syndrome. Anesthesiology 131:594–604
pubmed: 31335543
Toufen Junior C, De Santis Santiago RR, Hirota AS, Carvalho ARS, Gomes S, Amato MBP et al (2018) Driving pressure and long-term outcomes in moderate/severe acute respiratory distress syndrome. Ann Intensive Care 8:119
pubmed: 30535520
pmcid: 6286297
Guo L, Xie J, Huang Y, Pan C, Yang Y, Qiu H et al (2018) Higher PEEP improves outcomes in ARDS patients with clinically objective positive oxygenation response to PEEP: a systematic review and meta-analysis. BMC Anesthesiol 18:172
pubmed: 30447683
pmcid: 6240288
Serpa Neto A, Filho RR, Cherpanath T, Determann R, Dongelmans DA, Paulus F et al (2016) Associations between positive end-expiratory pressure and outcome of patients without ARDS at onset of ventilation: a systematic review and meta-analysis of randomized controlled trials. Ann Intensive Care 6:109
pubmed: 27813023
pmcid: 5095097
Torres A, Motos A, Riera J, Fernández-Barat L, Ceccato A, Pérez-Arnal R et al (2021) The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients. Crit Care 25:331
pubmed: 34517881
pmcid: 8436582
Amato MBP, Barbas CSV, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G et al (1998) Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 338:347–354
pubmed: 9449727
Brower R, Matthay M, Morris A, Schoenfeld D, Thompson B, Wheeler A (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308
pubmed: 10793162
Simonis FD, Serpa Neto A, Binnekade JM, Braber A, Bruin KCM, Determann RM et al (2018) Effect of a low vs intermediate tidal volume strategy on ventilator-free days in intensive care unit patients without ARDS. JAMA 320:1872
pubmed: 30357256
pmcid: 6248136
Tiruvoipati R, Pilcher D, Botha J, Buscher H, Simister R, Bailey M (2018) Association of hypercapnia and hypercapnic acidosis with clinical outcomes in mechanically ventilated patients with cerebral injury. JAMA Neurol 75:818–826
pubmed: 29554187
pmcid: 5885161
Beitler JR, Ghafouri TB, Jinadasa SP, Mueller A, Hsu L, Anderson RJ et al (2017) Favorable neurocognitive outcome with low tidal volume ventilation after cardiac arrest. Am J Respir Crit Care Med 195:1198–1206
pubmed: 28267376
pmcid: 5439016
Eastwood GM, Nichol A (2020) Optimal ventilator settings after return of spontaneous circulation. Curr Opin Crit Care 26:251–258
pubmed: 32348093
Eastwood GM, Young PJ, Bellomo R (2014) The impact of oxygen and carbon dioxide management on outcome after cardiac arrest. Curr Opin Crit Care 20:266–272
pubmed: 24717693
Farias LL, Faffe DS, Xisto DG, Santana MCE, Lassance R, Prota LFM et al (2005) Positive end-expiratory pressure prevents lung mechanical stress caused by recruitment/derecruitment. J Appl Physiol 98:53–61
pubmed: 15377644
Ricard J-D, Dreyfuss D, Saumon G (2003) Ventilator-induced lung injury. Eur Respir J 22:2s–9s
Schaefer MS, Serpa Neto A, Pelosi P, de Gama AM, Kienbaum P, Schultz MJ et al (2019) Temporal changes in ventilator settings in patients with uninjured lungs. Anesth Analg 129:129–140
pubmed: 30222649
Tejerina EE, Pelosi P, Robba C, Peñuelas O, Muriel A, Barrios D et al (2021) Evolution over time of ventilatory management and outcome of patients with neurologic disease. Crit Care Med 49:1095–1106
pubmed: 33729719
Esteban A (2002) Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 287:345
pubmed: 11790214
Sahetya SK, Fan E (2019) Driving pressure: the road ahead. Respir Care 64:1017–1020
pubmed: 31346077
Cressoni M, Gotti M, Chiurazzi C, Massari D, Algieri I, Amini M et al (2016) Mechanical power and development of ventilator-induced lung injury. Anesthesiology 124:1100–1108
pubmed: 26872367
Scharffenberg M, Wittenstein J, Ran X, Zhang Y, Braune A, Theilen R et al (2021) Mechanical power correlates with lung inflammation assessed by positron-emission tomography in experimental acute lung injury in pigs. Front Physiol 12:717266
pubmed: 34880770
pmcid: 8645956
Malik AB, Krasney JA, Royce GJ (1977) Respiratory influence on the total and regional cerebral blood flow responses to intracranial hypertension. Stroke 8:243–249
pubmed: 847790
Heffner JE (1983) Controlled hyperventilation in patients with intracranial hypertension. Arch Intern Med 143:765
pubmed: 6404229
Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet J-F, Eisner MD et al (2002) Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med 346:1281–1286
pubmed: 11973365
Goligher EC, EL Costa V, Yarnell CJ, Brochard LJ, Stewart TE, Tomlinson G et al (2021) Effect of lowering Vt on mortality in acute respiratory distress syndrome varies with respiratory system elastance. Am J Respir Crit Care Med 203:1378–1385
pubmed: 33439781