Exploring the brain metabolic correlates of process-specific CSF biomarkers in patients with MCI due to Alzheimer's disease: preliminary data.

Alzheimer Disease / metabolism Amyloid beta-Peptides / metabolism Biomarkers / cerebrospinal fluid Brain / diagnostic imaging Cognitive Dysfunction / metabolism Humans Neurogranin Positron-Emission Tomography / methods Preliminary Data alpha-Synuclein / metabolism beta-Synuclein / metabolism

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
09 2022
Historique:
received: 18 12 2021
revised: 08 03 2022
accepted: 15 03 2022
pubmed: 4 7 2022
medline: 20 7 2022
entrez: 3 7 2022
Statut: ppublish

Résumé

We explored the brain metabolism correlates of emergent cerebrospinal fluid (CSF) biomarkers in a group of 26 patients with prodromal Alzheimer's disease (AD). Distinct volumes of interest (VOIs) expressed the sites of correlation between CSF biomarkers and brain metabolism as determined on [

Identifiants

DOI: 10.1016/j.neurobiolaging.2022.03.019 PMID: 35780561
pubmed: 35780561
pii: S0197-4580(22)00113-0
doi: 10.1016/j.neurobiolaging.2022.03.019
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Biomarkers 0
alpha-Synuclein 0
beta-Synuclein 0
Neurogranin 132654-77-4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

212-221

Informations de copyright

Copyright © 2022. Published by Elsevier Inc.

Auteurs

Federico Massa (F)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy. Electronic address: fedemassa88@gmail.com.

Steffen Halbgebauer (S)

Department of Neurology, Ulm University Hospital, Ulm, Germany.

Lorenzo Barba (L)

Department of Neurology, Ulm University Hospital, Ulm, Germany; Department of Neurology, Martin-Luther-University of Halle-Wittenberg, Halle/Saale, Germany.

Patrick Oeckl (P)

Department of Neurology, Ulm University Hospital, Ulm, Germany; German Center for Neurodegenerative Diseases (DZNE e.v.), Ulm, Germany.

Nerea Gómez de San José (N)

Department of Neurology, Ulm University Hospital, Ulm, Germany.

Matteo Bauckneht (M)

IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Francesco Lanfranchi (F)

Department of Health Science (DISSAL), University of Genoa, Genoa, Italy.

Tiziana Vigo (T)

IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Dario Arnaldi (D)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Matteo Pardini (M)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Silvia Morbelli (S)

IRCCS Ospedale Policlinico San Martino, Genoa, Italy; Department of Health Science (DISSAL), University of Genoa, Genoa, Italy.

Andrea Chincarini (A)

National Institute of Nuclear Physics (INFN), Genoa section, Genoa, Italy.

Henryk Barthel (H)

Department of Nuclear Medicine, University Hospital of Leipzig, Leipzig, Germany.

Markus Otto (M)

Department of Neurology, Ulm University Hospital, Ulm, Germany; Department of Neurology, Martin-Luther-University of Halle-Wittenberg, Halle/Saale, Germany.

Flavio Nobili (F)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Exploring the brain metabolic correlates of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Exploring the brain metabolic correlates of...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Exploring the brain metabolic correlates of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Exploring the brain metabolic correlates of...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Exploring the brain metabolic correlates of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exploring the brain metabolic correlates of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neurogranine › Exploring the brain metabolic correlates of...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Exploring the brain metabolic correlates of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Données préliminaires › Exploring the brain metabolic correlates of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › Exploring the brain metabolic correlates of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Synucléines › bêta-Synucléine › Exploring the brain metabolic correlates of...