Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox.
NMR structure
gating modifier toxin
neuropharmacology
sodium channel
trichome
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
26
01
2022
revised:
22
06
2022
accepted:
28
06
2022
pubmed:
6
7
2022
medline:
9
9
2022
entrez:
5
7
2022
Statut:
ppublish
Résumé
The stinging hairs of plants from the family Urticaceae inject compounds that inflict pain to deter herbivores. The sting of the New Zealand tree nettle (Urtica ferox) is among the most painful of these and can cause systemic symptoms that can even be life-threatening; however, the molecular species effecting this response have not been elucidated. Here we reveal that two classes of peptide toxin are responsible for the symptoms of U. ferox stings: Δ-Uf1a is a cytotoxic thionin that causes pain via disruption of cell membranes, while β/δ-Uf2a defines a new class of neurotoxin that causes pain and systemic symptoms via modulation of voltage-gated sodium (Na
Identifiants
pubmed: 35780839
pii: S0021-9258(22)00660-3
doi: 10.1016/j.jbc.2022.102218
pmc: PMC9352542
pii:
doi:
Substances chimiques
Neurotoxins
0
Peptides
0
Toxins, Biological
0
Voltage-Gated Sodium Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102218Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.