Thomas Durek

Publications (37)

Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity.

Journal of medicinal chemistry

Avec: Jessica A Rowley , Robert C Reid , Eunice K Y Poon , Kai-Chen Wu , Junxian Lim , Rink-Jan Lohman , Johan K Hamidon , Mei-Kwan Yau , Maria A Halili , Thomas Durek , Abishek Iyer , David P Fairlie

Na

The Journal of physiology

Avec: Mathilde R Israel , Brian S Tanaka , Joel Castro , Panumart Thongyoo , Samuel D Robinson , Peng Zhao , Jennifer R Deuis , David J Craik , Thomas Durek , Stuart M Brierley , Stephen G Waxman , Sulayman D Dib-Hajj , Irina Vetter

Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework.

Journal of medicinal chemistry

Avec: Thomas Durek , Quentin Kaas , Andrew M White , Joachim Weidmann , Abdullah Ahmad Fuaad , Olivier Cheneval , Christina I Schroeder , Simon J de Veer , Anita Dellsén , Torben Österlund , Niklas Larsson , Laurent Knerr , Udo Bauer , Alleyn T Plowright , David J Craik

Native and Engineered Cyclic Disulfide-Rich Peptides as Drug Leads.

Molecules (Basel, Switzerland)

Avec: Tristan J Tyler , Thomas Durek , David J Craik

Tertiary amide bond formation by an engineered asparaginyl ligase.

Chemical science

Avec: Simon J de Veer , Yan Zhou , Thomas Durek , David J Craik , Fabian B H Rehm

Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Fabian B H Rehm , Mark A Jackson , Ewout De Geyter , Kuok Yap , Edward K Gilding , Thomas Durek , David J Craik

Site-Specific Sequential Protein Labeling Catalyzed by a Single Recombinant Ligase.

Journal of the American Chemical Society

Avec: Fabian B H Rehm , Thibault J Harmand , Kuok Yap , Thomas Durek , David J Craik , Hidde L Ploegh

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors.

Nature communications

Avec: Junqiao Du , Kuok Yap , Lai Yue Chan , Fabian B H Rehm , Fong Yang Looi , Aaron G Poth , Edward K Gilding , Quentin Kaas , Thomas Durek , David J Craik

Neurotoxic peptides from the venom of the giant Australian stinging tree.

Science advances

Avec: Edward K Gilding , Sina Jami , Jennifer R Deuis , Mathilde R Israel , Peta J Harvey , Aaron G Poth , Fabian B H Rehm , Jennifer L Stow , Samuel D Robinson , Kuok Yap , Darren L Brown , Brett R Hamilton , David Andersson , David J Craik , Irina Vetter , Thomas Durek

Enzymatic C-to-C Protein Ligation.

Angewandte Chemie (International ed. in English)

Avec: Fabian B H Rehm , Tristan J Tyler , Simon J de Veer , David J Craik , Thomas Durek

Pain-causing stinging nettle toxins target TMEM233 to modulate Na

Nature communications

Avec: Sina Jami , Jennifer R Deuis , Tabea Klasfauseweh , Xiaoyang Cheng , Sergey Kurdyukov , Felicity Chung , Andrei L Okorokov , Shengnan Li , Jiangtao Zhang , Ben Cristofori-Armstrong , Mathilde R Israel , Robert J Ju , Samuel D Robinson , Peng Zhao , Lotten Ragnarsson , Åsa Andersson , Poanna Tran , Vanessa Schendel , Kirsten L McMahon , Hue N T Tran , Yanni K-Y Chin , Yifei Zhu , Junyu Liu , Theo Crawford , Saipriyaa Purushothamvasan , Abdella M Habib , David A Andersson , Lachlan D Rash , John N Wood , Jing Zhao , Samantha J Stehbens , Mehdi Mobli , Andreas Leffler , Daohua Jiang , James J Cox , Stephen G Waxman , Sulayman D Dib-Hajj , G Gregory Neely , Thomas Durek , Irina Vetter

Development of Melanocortin 4 Receptor Agonists by Exploiting Animal-Derived Macrocyclic, Disulfide-Rich Peptide Scaffolds.

ACS pharmacology & translational science

Avec: Edin Muratspahić , Despoina Aslanoglou , Andrew M White , Claudia Draxler , Xaver Kozisek , Zara Farooq , David J Craik , Peter J McCormick , Thomas Durek , Christian W Gruber

Characterization of Synthetic Tf2 as a Na

Biomedicines

Avec: Mathilde R Israel , Thomas S Dash , Stefanie N Bothe , Samuel D Robinson , Jennifer R Deuis , David J Craik , Angelika Lampert , Irina Vetter , Thomas Durek

A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein.

Scientific reports

Avec: Karen S Harris , Rosemary F Guarino , Ravindu S Dissanayake , Pedro Quimbar , Owen C McCorkelle , Simon Poon , Quentin Kaas , Thomas Durek , Edward K Gilding , Mark A Jackson , David J Craik , Nicole L van der Weerden , Robin F Anders , Marilyn A Anderson

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.

Journal of medicinal chemistry

Avec: Joakim E Swedberg , Guojie Wu , Tunjung Mahatmanto , Thomas Durek , Tom T Caradoc-Davies , James C Whisstock , Ruby H P Law , David J Craik

Asparaginyl Ligases: New Enzymes for the Protein Engineer's Toolbox.

Chembiochem : a European journal of chemical biology

Avec: Fabian B H Rehm , Tristan J Tyler , Jing Xie , Kuok Yap , Thomas Durek , David J Craik

Nucleation of a key beta-turn promotes cyclotide oxidative folding.

The Journal of biological chemistry

Avec: Sixin Tian , Simon J de Veer , Thomas Durek , Conan K Wang , David J Craik

Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency.

Journal of medicinal chemistry

Avec: Alicia Peschel , Fernanda C Cardoso , Andrew A Walker , Thomas Durek , M Rhia L Stone , Nayara Braga Emidio , Philip E Dawson , Markus Muttenthaler , Glenn F King

Improved Asparaginyl-Ligase-Catalyzed Transpeptidation via Selective Nucleophile Quenching.

Angewandte Chemie (International ed. in English)

Avec: Fabian B H Rehm , Tristan J Tyler , Kuok Yap , Thomas Durek , David J Craik

Rapid and Scalable Plant-Based Production of a Potent Plasmin Inhibitor Peptide.

Frontiers in plant science

Avec: Mark A Jackson , Kuok Yap , Aaron G Poth , Edward K Gilding , Joakim E Swedberg , Simon Poon , Haiou Qu , Thomas Durek , Karen Harris , Marilyn A Anderson , David J Craik

Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides.

Angewandte Chemie (International ed. in English)

Avec: Andrew M White , Simon J de Veer , Guojie Wu , Peta J Harvey , Kuok Yap , Gordon J King , Joakim E Swedberg , Conan K Wang , Ruby H P Law , Thomas Durek , David J Craik

Enzymatic C-Terminal Protein Engineering with Amines.

Journal of the American Chemical Society

Avec: Fabian B H Rehm , Tristan J Tyler , Kuok Yap , Simon J de Veer , David J Craik , Thomas Durek

Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox.

The Journal of biological chemistry

Avec: Jing Xie , Samuel D Robinson , Edward K Gilding , Sina Jami , Jennifer R Deuis , Fabian B H Rehm , Kuok Yap , Lotten Ragnarsson , Lai Yue Chan , Brett R Hamilton , Peta J Harvey , David J Craik , Irina Vetter , Thomas Durek

Cystine Knot Peptides with Tuneable Activity and Mechanism.

Angewandte Chemie (International ed. in English)

Avec: Choi Yi Li , Fabian B H Rehm , Kuok Yap , Christina N Zdenek , Maxim D Harding , Bryan G Fry , Thomas Durek , David J Craik , Simon J de Veer

Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants.

Cellular and molecular life sciences : CMLS

Avec: Ben Cristofori-Armstrong , Elena Budusan , Jennifer J Smith , Steve Reynaud , Kerstin Voll , Irène R Chassagnon , Thomas Durek , Lachlan D Rash

Low potency inhibition of Na

European journal of pharmacology

Avec: Tabea Klasfauseweh , Mathilde R Israel , Lotten Ragnarsson , James J Cox , Thomas Durek , David A Carter , Andreas Leffler , Irina Vetter , Jennifer R Deuis

Chemical synthesis of grafted cyclotides using a "plug and play" approach.

RSC chemical biology

Avec: Johannes Koehbach , Edin Muratspahić , Zakaria M Ahmed , Andrew M White , Nataša Tomašević , Thomas Durek , Richard J Clark , Christian W Gruber , David J Craik

Isolation and Characterization of Insecticidal Cyclotides from

Journal of natural products

Avec: Negin Khatibi , Yen-Hua Huang , Conan K Wang , Thomas Durek , Edward K Gilding , David J Craik

Sortase-Catalyzed Protein Domain Inversion.

Angewandte Chemie (International ed. in English)

Avec: Yan Zhou , Thomas Durek , David J Craik , Fabian B H Rehm

A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins.

Structure (London, England : 1993)

Avec: Thomas S Dash , Thomas Shafee , Peta J Harvey , Chuchu Zhang , Steve Peigneur , Jennifer R Deuis , Irina Vetter , Jan Tytgat , Marilyn A Anderson , David J Craik , Thomas Durek , Eivind A B Undheim

Make it or break it: Plant AEPs on stage in biotechnology.

Biotechnology advances

Avec: Mark A Jackson , Linh T T Nguyen , Edward K Gilding , Thomas Durek , David J Craik

Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases.

Nature protocols

Avec: Kuok Yap , Junqiao Du , Fabian B H Rehm , Shyn Ric Tang , Yan Zhou , Jing Xie , Conan K Wang , Simon J de Veer , Linda H L Lua , Thomas Durek , David J Craik

Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA.

European journal of medicinal chemistry

Avec: Valentin Jakob , Ben G E Zoller , Julia Rinkes , Yingwen Wu , Alexander F Kiefer , Michael Hust , Saskia Polten , Andrew M White , Peta J Harvey , Thomas Durek , David J Craik , Andreas Siebert , Uli Kazmaier , Martin Empting

Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists.

Journal of medicinal chemistry

Avec: Andrew M White , Anita Dellsén , Niklas Larsson , Quentin Kaas , Frank Jansen , Alleyn T Plowright , Laurent Knerr , Thomas Durek , David J Craik

Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa.

Journal of medicinal chemistry

Avec: Sixin Tian , Thomas Durek , Conan K Wang , Christina N Zdenek , Bryan G Fry , David J Craik , Simon J de Veer

A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide).

Angewandte Chemie (International ed. in English)

Avec: Yan Zhou , Peta J Harvey , Johannes Koehbach , Lai Yue Chan , Alun Jones , Åsa Andersson , Irina Vetter , Thomas Durek , David J Craik

Repurposing a plant peptide cyclase for targeted lysine acylation.

Nature chemistry

Avec: Fabian B H Rehm , Tristan J Tyler , Yan Zhou , Yen-Hua Huang , Conan K Wang , Nicole Lawrence , David J Craik , Thomas Durek

Réseau de co-auteurs

David J Craik 32 collaborations

Fabian B H Rehm 14 collaborations

Kuok Yap 12 collaborations

Simon J de Veer 9 collaborations

Irina Vetter 8 collaborations

Edward K Gilding 8 collaborations

Jennifer R Deuis 7 collaborations

Andrew M White 6 collaborations

Tristan J Tyler 6 collaborations

Peta J Harvey 6 collaborations

Conan K Wang 6 collaborations

Mathilde R Israel 5 collaborations

Samuel D Robinson 5 collaborations

Yan Zhou 5 collaborations

Quentin Kaas 4 collaborations

Mark A Jackson 4 collaborations

Lai Yue Chan 3 collaborations

Aaron G Poth 3 collaborations

Sina Jami 3 collaborations

Lotten Ragnarsson 3 collaborations

Marilyn A Anderson 3 collaborations

Joakim E Swedberg 3 collaborations

Jing Xie 3 collaborations

Peng Zhao 2 collaborations

Stephen G Waxman 2 collaborations

Sulayman D Dib-Hajj 2 collaborations

Anita Dellsén 2 collaborations

Niklas Larsson 2 collaborations

Laurent Knerr 2 collaborations

Alleyn T Plowright 2 collaborations

Junqiao Du 2 collaborations

Brett R Hamilton 2 collaborations

Tabea Klasfauseweh 2 collaborations

Ben Cristofori-Armstrong 2 collaborations

Åsa Andersson 2 collaborations

Lachlan D Rash 2 collaborations

Andreas Leffler 2 collaborations

James J Cox 2 collaborations

Edin Muratspahić 2 collaborations

Christian W Gruber 2 collaborations

Thomas S Dash 2 collaborations

Simon Poon 2 collaborations

Guojie Wu 2 collaborations

Ruby H P Law 2 collaborations

Sixin Tian 2 collaborations

Christina N Zdenek 2 collaborations

Bryan G Fry 2 collaborations

Johannes Koehbach 2 collaborations

Yen-Hua Huang 2 collaborations

Jessica A Rowley 1 collaboration

Robert C Reid 1 collaboration

Eunice K Y Poon 1 collaboration

Kai-Chen Wu 1 collaboration

Junxian Lim 1 collaboration

Rink-Jan Lohman 1 collaboration

Johan K Hamidon 1 collaboration

Mei-Kwan Yau 1 collaboration

Maria A Halili 1 collaboration

Abishek Iyer 1 collaboration

David P Fairlie 1 collaboration

Brian S Tanaka 1 collaboration

Joel Castro 1 collaboration

Panumart Thongyoo 1 collaboration

Stuart M Brierley 1 collaboration

Joachim Weidmann 1 collaboration

Abdullah Ahmad Fuaad 1 collaboration

Olivier Cheneval 1 collaboration

Christina I Schroeder 1 collaboration

Torben Österlund 1 collaboration

Udo Bauer 1 collaboration

Ewout De Geyter 1 collaboration

Thibault J Harmand 1 collaboration

Hidde L Ploegh 1 collaboration

Fong Yang Looi 1 collaboration

Jennifer L Stow 1 collaboration

Darren L Brown 1 collaboration

David Andersson 1 collaboration

Xiaoyang Cheng 1 collaboration

Sergey Kurdyukov 1 collaboration

Felicity Chung 1 collaboration

Andrei L Okorokov 1 collaboration

Shengnan Li 1 collaboration

Jiangtao Zhang 1 collaboration

Robert J Ju 1 collaboration

Poanna Tran 1 collaboration

Vanessa Schendel 1 collaboration

Kirsten L McMahon 1 collaboration

Hue N T Tran 1 collaboration

Yanni K-Y Chin 1 collaboration

Yifei Zhu 1 collaboration

Junyu Liu 1 collaboration

Theo Crawford 1 collaboration

Saipriyaa Purushothamvasan 1 collaboration

Abdella M Habib 1 collaboration

David A Andersson 1 collaboration

John N Wood 1 collaboration

Jing Zhao 1 collaboration

Samantha J Stehbens 1 collaboration

Mehdi Mobli 1 collaboration

Daohua Jiang 1 collaboration

G Gregory Neely 1 collaboration

Despoina Aslanoglou 1 collaboration

Claudia Draxler 1 collaboration

Xaver Kozisek 1 collaboration

Zara Farooq 1 collaboration

Peter J McCormick 1 collaboration

Stefanie N Bothe 1 collaboration

Angelika Lampert 1 collaboration

Karen S Harris 1 collaboration

Rosemary F Guarino 1 collaboration

Ravindu S Dissanayake 1 collaboration

Pedro Quimbar 1 collaboration

Owen C McCorkelle 1 collaboration

Nicole L van der Weerden 1 collaboration

Robin F Anders 1 collaboration

Tunjung Mahatmanto 1 collaboration

Tom T Caradoc-Davies 1 collaboration

James C Whisstock 1 collaboration

Alicia Peschel 1 collaboration

Fernanda C Cardoso 1 collaboration

Andrew A Walker 1 collaboration

M Rhia L Stone 1 collaboration

Nayara Braga Emidio 1 collaboration

Philip E Dawson 1 collaboration

Markus Muttenthaler 1 collaboration

Glenn F King 1 collaboration

Haiou Qu 1 collaboration

Karen Harris 1 collaboration

Gordon J King 1 collaboration

Choi Yi Li 1 collaboration

Maxim D Harding 1 collaboration

Elena Budusan 1 collaboration

Jennifer J Smith 1 collaboration

Steve Reynaud 1 collaboration

Kerstin Voll 1 collaboration

Irène R Chassagnon 1 collaboration

David A Carter 1 collaboration

Zakaria M Ahmed 1 collaboration

Nataša Tomašević 1 collaboration

Richard J Clark 1 collaboration

Negin Khatibi 1 collaboration

Thomas Shafee 1 collaboration

Chuchu Zhang 1 collaboration

Steve Peigneur 1 collaboration

Jan Tytgat 1 collaboration

Eivind A B Undheim 1 collaboration

Linh T T Nguyen 1 collaboration

Shyn Ric Tang 1 collaboration

Linda H L Lua 1 collaboration

Valentin Jakob 1 collaboration

Ben G E Zoller 1 collaboration

Julia Rinkes 1 collaboration

Yingwen Wu 1 collaboration

Alexander F Kiefer 1 collaboration

Michael Hust 1 collaboration

Saskia Polten 1 collaboration

Andreas Siebert 1 collaboration

Uli Kazmaier 1 collaboration

Martin Empting 1 collaboration

Frank Jansen 1 collaboration

Alun Jones 1 collaboration

Nicole Lawrence 1 collaboration